Asymmetric synthesis of novel triazole derivatives and their in vitro antiviral activity and mechanism of action

Cao, Xiufang; Wang, Wenda; Wang, Shuangshuang; Bao, Longzhu

doi:10.1016/j.ejmech.2017.08.057

Cited by 76 publications

(43 citation statements)

References 24 publications

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“…[13,14] 1,2,4-Triazoles chemistry are fascinating heterocycles and their derivatives specially they belong to isothiocyanates (ITCs) [15][16][17][18][19][20][21] class. Also, they possess significant pharmacological activities such as antitumor, [22] antifungal, [23] antiviral, [24] stimulants sedatives, [25][26] anti-inflammatory, [27] and antimycotic agents, [28] for example, 1 fluconazole, 2 voriconazole, 3 Fluconazole, 4 itraconazole, 5 Triazolam, 6 Alprazolam, and 7 Etizolam (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Nano nickel [1,2,4]‐triazole‐3‐thiones complex: Design, sonochemical synthesis, and antimicrobial evaluation

Farag

Hemdan

El‐Sayed

2020

Journal of Heterocyclic Chem

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A series of new 1,2,4‐triazole‐3‐thiones were synthesized by calm, benign, no risk, eco‐friendly, and energy efficient sequential reaction methodology like grinding and ultrasonic (US). In addition, 1,2,4‐triazoles were prepared under conventional method and comparative study was done. The synthesized 1,2,4‐triazoles were complexed with Ni(II) to produce nanoparticles complexes (NPC's) with average particle size vary from 55 to 100 nm (using scanning electron microscope technique) with good yields via both US and conventional techniques. X‐ray diffraction technique and spectra analysis techniques were used to confirm the square planer geometry of the synthesized NPC's. Antimicrobial activity of the prepared 1,2,4‐triazoles and their nickel complexes were studied which evaluated a high activity with complexes instead their triazoles.

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Section: Introductionmentioning

confidence: 99%

Nano nickel [1,2,4]‐triazole‐3‐thiones complex: Design, sonochemical synthesis, and antimicrobial evaluation

Farag

Hemdan

El‐Sayed

2020

Journal of Heterocyclic Chem

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“…As for the Ar functionality, there was relatively high activity in the 4-methoxyphenyl or benzyl-containing compounds. [70] 1.4. Disubstituted-1,2,4-triazoles…”

Section: Monosubstituted 124-triazolesmentioning

confidence: 99%

“…Zhan et al synthesized a set of 1,2,4-triazolacetamide analogs and their anti-HIV activity was examined by assessing their ability to inhibit the replication of human immunodeficiency virus type; HIV-1 (IIIB) and HIV-2 (ROD) in MT-4 cells. Compounds (69)(70)(71)(72)(73)(74) (Figure 23) were the most active, exhibiting moderate to strong activity against HIV-1 strain IIIB with EC 50 values ranging from 2.78 to 6.21 μM, which are much better than dideoxyinosine (DDI). Amongst them, compound 72 was recognized as the most promising lead with favorable inhibitory activity against the wild-type HIV-1 reverse transcriptase (RT) against HIV-1(IIIB), as well as displayed the highest inhibitory activity against the HIV-1 K103 N strain.…”

Section: Aryl(hetero)124-triazololylthioacetanilidementioning

confidence: 99%

Recent Advances in 1,2,4‐Triazole Scaffolds as Antiviral Agents

El‐Sebaey

2020

ChemistrySelect

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In recent years, severe viral infections have emerged, and antiviral chemotherapeutic agents are not adequately effective in curing these infections, leading to serious human diseases and loss of life. Consequently, a novel antiviral is urgently needed, which undoubtedly essential for the therapy of various fatal and debilitating viral infections. 1,2,4-Triazole derivatives occupy a pivotal position in modern medicinal chemistry and have been incorporated in numerous clinical drugs, including antiviral drugs. To my best knowledge, there are few review articles exclusively handling 1,2,4-triazole scaffold with the antiviral potential. This review aims to figure out recent perspectives and advances of 1,2,4-triazole nucleus roles in various kinds of antiviral agents over the past decade, with some examples of rational design and some structure-activity relationships. This review will hopefully provide perception into especially powerful compounds as lead structures and help in the rational design and development of novel 1,2,4-triazolebased compounds with strong anti-virus efficacy.

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“…Ñåðåä N-äîíîðíèõ ë³ãàíäíèõ ñèñòåì ïîõ³äí³ 1,2,4-òðèàçîëó ç ð³çíèìè çàì³ñíèêàìè ïðèâåðòàþòü óâàãó òîìó, ùî âîíè ³ ó íåêîîðäèíîâàíîìó ñòàí³ ïðîÿâëÿþòü ð³çíîìàí³òíó ôàðìàêîëî-ã³÷íó àêòèâí³ñòü: ïðîòèïóõëèííó [8], àíòèáàê-òåð³àëüíó [9] òà ïðîòèâ³ðóñíó [10] ö³éíó ïðèäàòí³ñòü âèêîðèñòàííÿ öèõ ñïîëóê ó ÿêîñò³ â³çóàë³çóþ÷èõ àãåíò³â.…”

Section: âñòóïunclassified

Synthesis, structure and properties of bromotricarbonyl-ethyl 3-(2-pyridin-2-il)-1H-1,2,4-triazol-5-carboxylate rhenium(I)

Kharlova¹,

Khomenko²,

Doroshchuk³

et al. 2019

VKhKhT

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The synthesis of a new complex Re I (CO) 3 (HL)Br, where HL is ethyl 3-(2-pyridin-2-yl)-1H-1,2,4-triazole-5-carboxylate, is described in this work. By means of 1 H and 13 C NMR, IR, and UV-à á Ðèñ. 7. Ê³íåòèêà çàãàñàííÿ ëþì³íåñöåíö³¿ Re ² (CO) 3 (HL)Br ïðè 298 Ê (à) òà 77 Ê (á) (êðàïêè-åêñïåðèìåíòàëüí³ äàí³, ë³í³ÿ-êðèâà åêñïîíåíö³éíî¿ ï³äãîíêè)

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Asymmetric synthesis of novel triazole derivatives and their in vitro antiviral activity and mechanism of action

Cited by 76 publications

References 24 publications

Nano nickel [1,2,4]‐triazole‐3‐thiones complex: Design, sonochemical synthesis, and antimicrobial evaluation

Nano nickel [1,2,4]‐triazole‐3‐thiones complex: Design, sonochemical synthesis, and antimicrobial evaluation

Recent Advances in 1,2,4‐Triazole Scaffolds as Antiviral Agents

Synthesis, structure and properties of bromotricarbonyl-ethyl 3-(2-pyridin-2-il)-1H-1,2,4-triazol-5-carboxylate rhenium(I)

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