Nano nickel [1,2,4]‐triazole‐3‐thiones complex: Design, sonochemical synthesis, and antimicrobial evaluation

Abstract

A series of new 1,2,4‐triazole‐3‐thiones were synthesized by calm, benign, no risk, eco‐friendly, and energy efficient sequential reaction methodology like grinding and ultrasonic (US). In addition, 1,2,4‐triazoles were prepared under conventional method and comparative study was done. The synthesized 1,2,4‐triazoles were complexed with Ni(II) to produce nanoparticles complexes (NPC's) with average particle size vary from 55 to 100 nm (using scanning electron microscope technique) with good yields via both US and conventional techniques. X‐ray diffraction technique and spectra analysis techniques were used to confirm the square planer geometry of the synthesized NPC's. Antimicrobial activity of the prepared 1,2,4‐triazoles and their nickel complexes were studied which evaluated a high activity with complexes instead their triazoles.

New pyrazolo[3,4-d]pyrimidine derivatives as EGFR-TK inhibitors: design, green synthesis, potential anti-proliferative activity and P-glycoprotein inhibition

“…35 ppm with equal coupling constants typical of -CH 2 CH 3 protons, as well as a singlet signal at 5.44 ppm for ÀCH 2 À COOEt protons, all of which are completely consistent with the uncyclized structure, compound 5 with ruling out the cyclized product 3. Furthermore, the13 C-NMR spectrum of structure 5 matches the hypothesized structure well.…”

“…Our current research is concerned with the utility of N -(4-(4-chlorobenzylidene)-4 H -pyrazol-3-yl)benzamide (1) in the synthesis of new substituted fused pyrimidine derivatives under conventional and green conditions as part of our interest in the synthesis of a wide range of heterocyclic systems with biological applications. 34–37…”

“…Our current research is concerned with the utility of N-(4-(4chlorobenzylidene)-4H-pyrazol-3-yl)benzamide (1) in the synthesis of new substituted fused pyrimidine derivatives under conventional and green conditions as part of our interest in the synthesis of a wide range of heterocyclic systems with biological applications. [34][35][36][37] The starting chemical, N-(4-(4-chlorobenzylidene)-5-oxo-4,5dihydro-1H-pyrazol-3-yl)benzamide (1), was synthesized according to an earlier reported procedure 38 under different chemical reaction conditions. Thus, reuxing of compound 1 with ethanolic solution of thiourea in the presence of catalytic amount of sodium ethoxide or under free solvent fusion technique to afford the target compound N-(4-(4-chlorophenyl)-6thioxo-6,7-dihydro-5H-pyrazolo [3,4-d]pyrimidin-3-yl)benzamide (2) with a benecial yield, which was used as a key starting material as illustrated in (Scheme 1).…”

The Reformatsky analogous reaction for the synthesis of novel β-thioxoestersviausing aroyl isothiocyanates under solvent-free ball milling and conventional conditions

“…The research began with the treatment of the model substrates, benzoyl isothiocyanate (1) [10][11][12][13][14] (1 mmol) and ethyl 2-bromoacetate (2) (1.5 mmol) with 1 equivalent of zinc (dust <10 mm) heated at 60 C in benzene (15 ml) for 1-3 h under an N 2 atmosphere, as shown in Table 1. The reaction mixture was cooled to 0 C in ice and then the reaction was quenched with 10% HCl.…”

New 1,3,4-thiadiazoles as potential anticancer agents: pro-apoptotic, cell cycle arrest, molecular modelling, and ADMET profile

“…As a part of our ongoing research that aims at developing simple and efficient synthetic techniques for the synthesis of novel heterocyclic compounds with potential anticancer applications, [21][22][23][24][25][26][27][28][29][30][31] the present study reported the synthesis of numerous new substituted 1,3,4-thiadiazole derivatives incorporating benzene moiety. N-(5-Amino-1,3,4-thiadiazol-2-yl) benzamide (2) was synthesized as a sole product through reaction of benzoylisothiocyanate with thiosemicarbzide in dry acetonitrile and then underwent cyclization according to the previously published methodology [32][33][34][35][36] (Scheme 1). Treatment of compound 2 with ethyl cyanoacetate in the presence of a catalytic amount of triethylamine afforded N-(5-(2-cyanoacetamido)-1,3,4-thiadiazol-2-yl)benzamide (3) in a high yield, which was used as a key starting material (Scheme 1).…”