Recent Advances in 1,2,4‐Triazole Scaffolds as Antiviral Agents

Abstract

In recent years, severe viral infections have emerged, and antiviral chemotherapeutic agents are not adequately effective in curing these infections, leading to serious human diseases and loss of life. Consequently, a novel antiviral is urgently needed, which undoubtedly essential for the therapy of various fatal and debilitating viral infections. 1,2,4-Triazole derivatives occupy a pivotal position in modern medicinal chemistry and have been incorporated in numerous clinical drugs, including antiviral drugs. To my best knowledge, there are few review articles exclusively handling 1,2,4-triazole scaffold with the antiviral potential. This review aims to figure out recent perspectives and advances of 1,2,4-triazole nucleus roles in various kinds of antiviral agents over the past decade, with some examples of rational design and some structure-activity relationships. This review will hopefully provide perception into especially powerful compounds as lead structures and help in the rational design and development of novel 1,2,4-triazolebased compounds with strong anti-virus efficacy.

Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate

“…1,2,3-Triazoles, constituting another important class of heterocycles, widely used in medicinal chemistry, act as pharmacophores and linkers between two or more substances of interest in molecular hybridization approaches [36]. Several of these triazoles have a wide spectrum of biological effects such as anti-HIV [37], antiviral [38], cytotoxic, antiinflammatory [16,18], and antibacterial [39] activities (Figure 3). In our previous works, Chouaïb et al have described the isolation of OA and MA from pomace olive (Olea europaea L.) which have been used as a starting material to pre- 1,2,3-Triazoles, constituting another important class of heterocycles, widely used in medicinal chemistry, act as pharmacophores and linkers between two or more substances of interest in molecular hybridization approaches [36].…”

“…In our previous works, Chouaïb et al have described the isolation of OA and MA from pomace olive (Olea europaea L.) which have been used as a starting material to pre- 1,2,3-Triazoles, constituting another important class of heterocycles, widely used in medicinal chemistry, act as pharmacophores and linkers between two or more substances of interest in molecular hybridization approaches [36]. Several of these triazoles have a wide spectrum of biological effects such as anti-HIV [37], antiviral [38], cytotoxic, antiinflammatory [16,18], and antibacterial [39] activities (Figure 3).…”

“…1,2,3-Triazoles, constituting another important class of heterocycles, widely used in medicinal chemistry, act as pharmacophores and linkers between two or more substances of interest in molecular hybridization approaches [36]. Several of these triazoles have a wide spectrum of biological effects such as anti-HIV [37], antiviral [38], cytotoxic, antiinflammatory [16,18], and antibacterial [39] activities (Figure 3). In our previous works, Chouaïb et al have described the isolation of OA and MA from pomace olive (Olea europaea L.) which have been used as a starting material to pre- In our previous works, Chouaïb et al have described the isolation of OA and MA from pomace olive (Olea europaea L.) which have been used as a starting material to prepare new series of congeners constituting a library of novel pentacyclic triterpenoid derivatives bearing esters, 3,5-disubstituted isoxazoles, 1,5-and 1,4-disubstituted triazoles and were synthesized as antimicrobial, anti-inflammatory and anticancer agents [15][16][17][18].…”

Synthesis and herbicidal activity of pyrimidyl‐1,2,4‐triazole derivatives containing aryl sulfonyl moiety

“…As a class of nitrogen-containing five-membered heterocyclic compounds, 1,2,4-triazoles play a crucial role in the development of agrochemicals and drug molecules due to their interesting structural features and outstanding biological properties, such as antioxidant [9], antiproliferative [10], antimicrobial [11], antifungal [12], antitubercular [13], anticancer [14], antiinflammatory [15], antiviral [16], anti-HIV [17], molluscicidal [18], and herbicidal [19]. Currently, many 1,2,4-triazole derivatives have been marketed as herbicides, including carfentrazone and flupoxam [20].…”

Adsorption Behavior of an Adamantane Derivative on Metal Clusters – DFT Simulation Studies

“…Viral diseases are deadly and one of the leading causes of human life around the world and they are increasing at an alarming rate, along with emergence of new viruses and mutations in the genomes of those that already exist [1]. Because of the scarcity of effective medications and fear of unknown, new viruses draw a lot of attention [2,3].…”