Association between uric acid and pulse wave velocity in hypertensive patients and in the general population: a systematic review and meta-analysis

Rebora, Paola; Andreano, Anita; Triglione, Nicola; Piccinelli, Enrico; Palazzini, Matteo; Occhi, Lucia; Grassı, Guıdo; Valsecchi, Maria Grazia; Giannattasio, Cristina; Maloberti, Alessandro

doi:10.1080/08037051.2020.1735929

Cited by 23 publications

(22 citation statements)

References 44 publications

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“…Rhee TM et al showed that baPWV was positively correlation with four cardiovascular different risk scores and the correlation was stronger in women than in men [26]. A systematic review and meta-analysis also found that serum uric acid was positively association with baPWV in women, but not in men [27]. Along with these ndings, our result highlights the evidence to support more powerful predicted value of serum ALP level for high baPWV in women than in men.…”

Section: Discussionsupporting

confidence: 81%

Serum alkaline phosphatase is associated with arterial stiffness and 10‐year cardiovascular disease risk in a Chinese population

Guo

et al. 2021

Eur J Clin Investigation

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BackgroundSerum alkaline phosphatase (ALP) has been recognized as a biomarker of cardiovascular disease (CVD) risk or mortality, recently. This study aimed to explore the association of ALP with arterial stiffness and 10-year CVD risk. MethodsA total of 12539 participants without CVD who underwent health examinations including serum ALP level were retrospectively analyzed. Arterial stiffness was measured by brachial ankle pulse wave velocity (baPWV) and10-year CVD risk was evaluated by Framingham risk score (FRS). ResultsAll participants were strati ed into four groups according to the quartile of serum ALP. Participants with high ALP quartiles had higher cardiovascular parameters and baPWV, as well as an increase 10-year CVD risk. Logistic regression analysis showed that serum ALP was an independently risk factor for elevated baPWV and 10-year CVD risk after adjustment for traditional CVD risk factors in both women and men. In receiver operating characteristic (ROC) curve analysis, the area under the ROC curve (AUROC) of serum ALP for predicting elevated baPWV was 0.740 (95%CI 0.726-0.754, P < 0.001) in women, larger than that in men.

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Section: Discussionsupporting

confidence: 81%

Serum alkaline phosphatase is associated with arterial stiffness and 10‐year cardiovascular disease risk in a Chinese population

Guo

et al. 2021

Eur J Clin Investigation

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“…Secondly, elevated SUA level is associated with endothelial dysfunction and increased platelet adhesiveness which predispose to thrombus formation, elevated circulating levels of systemic inflammatory mediators, and vascular smooth muscle proliferation [ 11 ]. Thus, hyperuricemia exerts a pathological role in development of arterial stiffness [ 24 , 25 ], atherosclerosis and essential hypertension [ 26 , 27 ] and leads to ischemic stroke. Partially consistent with this hypothesis, in this study, a significantly higher level of SUA was found in hypertensive ischemic stroke patients comparing to the non-hypertensive one.…”

Section: Discussionmentioning

confidence: 99%

Role of serum uric acid in ischemic stroke: A case-control study in Bangladesh

et al. 2020

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Introduction Increased level of serum uric acid (SUA) is often considered a risk factor for ischemic stroke. This study was conducted to examine the association of SUA level with ischemic stroke and assessed gender-based differences, if any. Methods In this case-control study, neuroimaging-confirmed ischemic stroke patients were recruited as cases within three days of an incident from neurology in-patient department, and as controls, patients without stroke history were recruited from neurology outpatient department. Blood was collected from the respondents of both groups to assess SUA level, lipid profile and oral glucose tolerance test. Binary logistic regression was done for estimating the risks of ischemic stroke. Results A total of 338 participants were recruited, where 169 were cases and 169 were controls. Around 60 percent respondents of both case and control groups were male. Mean SUA levels for cases and controls were 6.03 (SD 1.84) mg/dl and 4.04 (SD 1.46) mg/dl, respectively. After adjustment for age, tobacco consumption status, diabetes, hypertension, coronary heart disease and dyslipidemia, elevated SUA level was found to be significantly associated with ischemic stroke only in females (OR = 1.49; 95% CI = 1.01-2.19; p<0.05). Overall, each unit increase in SUA level exhibits 25 percent increment in odds of having ischemic stroke (OR = 1.25; 95% CI = 1.02-1.5372; p<0.05).

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“…A possible explanation was the presence of metabolic syndrome as a confounding factor, which was included in the regression analysis. Similarly, a recent meta-analysis has shown an association of serum uric acid levels and pulse wave velocity (both carotid-femoral and brachialankle) in the general population (22). Thus, while more robust evidence pointing towards clear causation is lacking, uric acid may play a significant role in the development of cardio-vascular complications through various mechanisms, such as endothelial dysfunction and arterial stiffness.…”

Section: Role Of Hyperuricemia In Metabolic Syndromementioning

confidence: 99%

Uric acid as a predictor of endothelial dysfunction in patients with metabolic syndrome

Singh

Jain

Dhawan

et al. 2020

Archives of Endocrinology and Metabolism

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Objective: We conducted a study to examine the association of endothelial dysfunction and oxidative stress with uric acid levels in patients of metabolic syndrome. Subjects and methods: One hundred and two patients of Metabolic Syndrome (International Diabetes Federation definition) were included in the study. Anthropometric measurements, serum uric acid levels, fasting blood sugar levels and lipid levels, as well as malondialdehyde and reactive nitrogen intermediates were measured after an 8-hour fasting period. Flow mediated vasodilation (FMD) of the brachial artery was measured and endothelial dysfunction was defined as an increase in diameter < 10% post compression. Results: A total of 102 patients were included in the study. Mean uric acid level was 5.49 ± 1.61 mg%. A total of 59 patients in the study had endothelial dysfunction, defined by an abnormal FMD. Patients with an abnormal FMD had higher levels of serum uric acid which was statistically significant (p value = 0.010). Serum RNI and MDA levels were negatively correlated with uric acid, but did not reach statistical significance. Patients with an abnormal FMD had a lower RNI level, but this did not reach statistical significance. Serum MDA levels were significantly higher in patients with an abnormal FMD (p value = 0.038). Conclusions: Uric acid was significantly associated with endothelial dysfunction in patients with metabolic syndrome in our study. It was inversely correlated with serum RNI and MDA levels, but this did not reach statistical significance.

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Association between uric acid and pulse wave velocity in hypertensive patients and in the general population: a systematic review and meta-analysis

Cited by 23 publications

References 44 publications

Serum alkaline phosphatase is associated with arterial stiffness and 10‐year cardiovascular disease risk in a Chinese population

Serum alkaline phosphatase is associated with arterial stiffness and 10‐year cardiovascular disease risk in a Chinese population

Role of serum uric acid in ischemic stroke: A case-control study in Bangladesh

Uric acid as a predictor of endothelial dysfunction in patients with metabolic syndrome

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