Role of serum uric acid in ischemic stroke: A case-control study in Bangladesh

Abstract

Introduction Increased level of serum uric acid (SUA) is often considered a risk factor for ischemic stroke. This study was conducted to examine the association of SUA level with ischemic stroke and assessed gender-based differences, if any. Methods In this case-control study, neuroimaging-confirmed ischemic stroke patients were recruited as cases within three days of an incident from neurology in-patient department, and as controls, patients without stroke history were recruited from neurology outpatient department. Blood was collected from the respondents of both groups to assess SUA level, lipid profile and oral glucose tolerance test. Binary logistic regression was done for estimating the risks of ischemic stroke. Results A total of 338 participants were recruited, where 169 were cases and 169 were controls. Around 60 percent respondents of both case and control groups were male. Mean SUA levels for cases and controls were 6.03 (SD 1.84) mg/dl and 4.04 (SD 1.46) mg/dl, respectively. After adjustment for age, tobacco consumption status, diabetes, hypertension, coronary heart disease and dyslipidemia, elevated SUA level was found to be significantly associated with ischemic stroke only in females (OR = 1.49; 95% CI = 1.01-2.19; p<0.05). Overall, each unit increase in SUA level exhibits 25 percent increment in odds of having ischemic stroke (OR = 1.25; 95% CI = 1.02-1.5372; p<0.05).

The Relationship Between Elevated Serum Uric Acid and Risk of Stroke in Adult: An Updated and Dose–Response Meta-Analysis

“…Researches demonstrated that UA is an antioxidant factor to protect nerves from oxidative damage (6,7), thereby possibly preventing stroke outcomes. Whereas, many studies found that high SUA levels might be a major risk factor for the onset of stroke (8)(9)(10)(11). Zhong et al explored the association between SUA levels and risk of stroke base on a meta-analysis (12).…”

Prospective Study of Serum Uric Acid Levels and First Stroke Events in Chinese Adults With Hypertension

“…Most epidemiological studies but not all of them suggested the existence of an association between elevated SUA levels and cardiovascular diseases (CVDs), such as stroke ( Lehto et al, 1998 ; Chien et al, 2005 ; Bos et al, 2006 ; Gerber et al, 2006 ; Hozawa et al, 2006 ; Kim et al, 2009 ; Chao et al, 2014 ; Li et al, 2014 ; Shi et al, 2017 ; Tu et al, 2019 ; Li J. et al, 2020 ; Zhang et al, 2020 ), CHD, arterial hypertension, and an increased risk for mortality due to CVDs in general population and subjects with confirmed CHD ( Ndrepepa, 2018b ; Khalil et al, 2020 ; Tatsumi et al, 2020 ). In the Saku study, HUA was found to be independently associated with the development of hypertension independent of alcohol drinking status ( Ndrepepa, 2018b ).…”

Hyperuricemia and Its Association With Ischemic Stroke

“…Ten studies have been included in this review. The following inclusion criteria were used based on the authors' discretion: patients with confirmed ischemic stroke, patients with confirmed hyperuricemia, and sample size >50 [9,17,36,[55][56][57][58][59][60][61].…”