Serum alkaline phosphatase is associated with arterial stiffness and 10‐year cardiovascular disease risk in a Chinese population

Abstract

BackgroundSerum alkaline phosphatase (ALP) has been recognized as a biomarker of cardiovascular disease (CVD) risk or mortality, recently. This study aimed to explore the association of ALP with arterial stiffness and 10-year CVD risk. MethodsA total of 12539 participants without CVD who underwent health examinations including serum ALP level were retrospectively analyzed. Arterial stiffness was measured by brachial ankle pulse wave velocity (baPWV) and10-year CVD risk was evaluated by Framingham risk score (FRS). ResultsAll participants were strati ed into four groups according to the quartile of serum ALP. Participants with high ALP quartiles had higher cardiovascular parameters and baPWV, as well as an increase 10-year CVD risk. Logistic regression analysis showed that serum ALP was an independently risk factor for elevated baPWV and 10-year CVD risk after adjustment for traditional CVD risk factors in both women and men. In receiver operating characteristic (ROC) curve analysis, the area under the ROC curve (AUROC) of serum ALP for predicting elevated baPWV was 0.740 (95%CI 0.726-0.754, P < 0.001) in women, larger than that in men.

Factors affecting blood pressure in patients with arterial hypertension and subclinical hypothyroidism

“…The level of PBP in patients with SH was associate with more factors than in euthyroid patients with HTN, namely by gender, hemoglobin, AP levels, which does not contradict the results of other researchers: PBP levels are indirectly associated with AP via arterial stiffness [34,35] and independently associated with anemia [36] and worse metabolic profile in women [37]. Moreover, patients with a combined course of HTN and SH tend to have anemia and liver abnormalities, which makes the effect of hemoglobin and AP levels more noticeable in this category of patients.…”

Positive association between alkaline phosphatase and arteriosclerosis: a cross-sectional study

“…However, prior to the present study, the association between serum ALP and Ba-PWV had not been investigated thoroughly, especially in a regular population. In our literature review, we found only one previous study on the association between serum ALP and Ba-PWV in a Chinese population 29 . Although that study also observed a significant relationship between ALP and Ba-PWV, we also observed a specific saturation effect in this relationship.…”

“…In our literature review, we found only one previous study on the association between serum ALP and Ba-PWV in a Chinese population. 29 Although that study also observed a significant relationship between ALP and Ba-PWV, we also observed a specific saturation effect in this relationship. Moreover, we explored the association in further subgroup analyses to obtain new findings that provide insight for the design of further research.…”

Alkaline Phosphatase: An Old Friend as Treatment Target for Cardiovascular and Mineral Bone Disorders in Chronic Kidney Disease

“…Mice with endothelial ALP overexpression have been shown to have an increased risk of developing arterial hypertension and compensatory left ventricular hypertrophy [ 76 ] ( Table 1 ). This finding was confirmed by a retrospective study of 12,539 patients without CVD, in which it was observed that elevated ALP levels were independently associated with arterial stiffness and an increased 10-year cardiovascular risk [ 77 ]. Similarly, Perticone et al demonstrated in a study of 500 hypertensive patients without CKD, that elevated ALP values were associated with an alteration in endothelium-dependent vasodilation, an important measure of endothelial dysfunction [ 78 ].…”