Association between sleep disorders and subsequent chronic spontaneous urticaria development

Abstract

Patients with chronic spontaneous urticaria (CSU) often have sleep disorders (SDs) because of pruritus. However, SDs might also contribute to the development of CSU. Here, we present the first population-based cohort study on the association between SDs and subsequent CSU development.This study investigated whether SDs increase the risk of CSU by using a population-based database in Taiwan.This retrospective matched-cohort study included 105,892 patients with new-onset SDs (SD cohort) and 105,892 randomly selected controls (control cohort). Each patient was monitored for 10 years to individually identify patients who were subsequently diagnosed as having CSU during the follow-up period. A Cox proportional hazard regression analysis was conducted to determine the risk of CSU in patients with SDs compared with the controls.All relevant comorbidities were more prevalent in the SD cohort than in the control cohort (P < .001). During the follow-up period, the incidence rates of CSU among the patients with SDs and controls were 53.4 and 28.3 per 10,000 person-years, respectively. After adjustment for age, sex, and comorbidities, the adjusted hazard ratio for CSU in the SD cohort was 1.83 (95% confidence interval = 1.73–1.93, P < .001).The risk of CSU was higher in the patients with SDs than in the controls.

Evaluation of intestinal parasites in patients with chronic spontaneous urticaria in a territory hospital in Turkey

“…Chronic spontaneous urticaria is a chronic disease, which worsens the quality of life, disturbs daily activities and sleep pattern because of pruritus and causes emotional disorders and social isolation [11,12]. Several studies indicate that CU has a significant impact on patient's psychological state.…”

“Chronic urticaria and obstructive sleep apnea: Is there a significant association?”

“…Despite the wide-ranging spectrum that sleep-related breathing disorders represent, few studies have explored the association between obstructive sleep apnea (OSA) and CU. 12 , 13 For instance, a previous study found that 40% of CU patients had OSA assessed through polysomnography, a rate which appears higher than reported for the general population. 14 It is still unclear whether CU increases the risk for developing OSA, or the latter increases the risk for CU.…”

“… 14 It is still unclear whether CU increases the risk for developing OSA, or the latter increases the risk for CU. 13 There are many unanswered questions including what the risk is for OSA among CU patients and its influence on CU disease severity and control. Thus, this study aims to expand the current knowledge on OSA and CU by determining in a sample cohort of Latin American CU patients, the frequency of risk categories for undiagnosed OSA and how they might correlate with CU clinical and patient reported outcomes.…”

Obstructive sleep apnea syndrome in patients with chronic idiopathic urticaria

“…In a previous cohort study, 46% of patients with urticaria had sleep apnea and this rate was similar to our study. 8 To the best of our knowledge, there are no studies showing the relationship between urticaria severity and AHI.…”

“…6 There have been a few studies examining the relationship between urticaria and OSAS. 7,8 In addition, to the best of our knowledge, one of the study was cohort study, and the other one did not have control group and there have been no case-controlled study that detected sleep apne disorders in chronic urticaria patients. In this study, we aimed to investigate the relationship between urticaria and OSAS.…”