Assessment of Antioxidant Capacity and Cytotoxicity of Selected Malaysian Plants

Abstract

Thirteen Malaysian plants; Artocarpus champeden, Azadirachta indica, Fragaria x ananassa, Garcinia mangostana, Lawsonia inermis, Mangifera indica, Nephelium lappaceum, Nephelium mutobile, Peltophorum pterocarpum, Psidium guajava and Syzygium aqueum, selected for their use in traditional medicine, were subjected to a variety of assays. Antioxidant capability, total phenolic content, elemental composition, as well as it cytotoxity to several cell lines of the aqueous and ethanolic extracts from different parts of these selected Malaysian plants were determined. In general, the ethanolic extracts were better free radical scavengers than the aqueous extracts and some of the tested extracts were even more potent than a commercial grape seed preparation. Similar results were seen in the lipid peroxidation inhibition studies. Our findings also showed a strong correlation of antioxidant activity with the total phenolic content. These extracts when tested for its heavy metals content, were found to be below permissible value for nutraceutical application. In addition, most of the extracts were found not cytotoxic to 3T3 and 4T1 cells at concentrations as high as 100 μg/mL. We conclude that although traditionally these plants are used in the aqueous form, its commercial preparation could be achieved using ethanol since a high total phenolic content and antioxidant activity is associated with this method of preparation.

Phytochemical Screening, Total Phenolic Contents and Antioxidant Activity ofSyzygium caryophyllatumandSyzygium densiflorum

“…It is found that antioxidant activity of S. caryophyllatum extracts increased proportionally to the polyphenol content with a linear relationship between DPPH values and total polyphenols 39 . The results here reported for DPPH radical scavenging are comparables and in accordance with those reported by some authors for some syzygium species extracts (S. jambolana, S. cumini, S. aqueum, S. grantum) for DPPH and other radical scavenging [40][41][42][43][44][45][46][47] . From this study, it can be inferred that S. caryophyllaum and S. densiflorum are also equally having antioxidant proprieties.…”

Malaysian Medicinal Plants’ Potential for Breast Cancer Therapy

“…Inhibition of lipid peroxidation as exhibited by Garcinia mongostana [54], Alstonia scholaris [55,56] and Annona muricata [49,57,58]. 2.…”

“…3. Inhibiting proliferation via the activation of caspase-3 and caspase-9, up-regulation of the ratio of bax/bcl-2 protein expression in Ardisia brevicaulis [61] Artocarpus obtusus [50,62] Ardisia brecaulis [63], Carica papaya [64] Catharanthus roseus [118][119], Costus speciosus [121][122], Cucuma zedoaria [65], Dysoxylum cauliforum [66], Goniosthalamus macrophyllus [137][138], Gynura procumbens [139], Lawsonia inermis [56,[146][147], Leea indica [148][149], Nepthelium lappaceum [56,156] Pandanus amarylfolius [41], Phyla nodiflora [67], Physalis minima [52,78], Rhodiola rosea [68], Vernonia amygdalina [65] and Schima wallichi [38]. 4.…”

Production and Potency of Local Rambutan at East Java as a Candidate Phytopharmaca

“…The increasing market demand for rambutan will also increase its waste because rambutan peel is still considered as waste and has never been used yet. Peel of rambutan has a potential as an afford able herbal medicine due to its phytochemical compounds (Ling et al, 2010;Wulandari and Lestari, 2012). Identification tannins compounds by TLC, B HPLC chromatograms, peak 1 is ellagic acid, peak 2 is coraligiin and peak 3 is geraniin, C FT-IR interpretation RPE fuctional bunch…”