Malaysian Medicinal Plants’ Potential for Breast Cancer Therapy

Abstract

Objective: This review focused on Malaysian medicinal plants that have been evaluated and pose potentials to treat breast cancer. Results: A total of 105 plants species representing 54 different families and 79 genera were reviewed. 97% of the plants were tested using MCF-7 and MDA-231 breast cancer cell lines and exhibited most significant in vitro anticancer activity, and 3% were tested using another type of breast cancer cell lines. Most of the bioactive compounds of the medicinal plants that exhibited good activity (IC 50 values <120 µg/mL) are a group of phenols, alkaloids, flavonoids, terpenoids, and saponins. Induction of apoptosis was found to be the significant cell death pathway. Methods Conclusion:This article reviews the available literature concerning research on anti-breast cancer plants. Furthermore, identification and characterization of active components and toxicology evaluation also need to be studied in details and also point out their clinical trials.

GC-MS Analysis of Phytochemical Constituents from Ethyl Acetate and Methanol Extract of Artocarpus altilis (Parkinson) Fosberg from Endau Rompin, Johor, Malaysia

“…Many of the isolated compounds exhibit biological activity such as inhibit platelet aggregation, anti-bacterial activity, anti-fungal properties, inhibition of leukaemia cells and as an anti-tumour agent [6]. Some of the bioactive compounds that were isolated and found to be responsible for the anticancer activities from A. altilis that exhibited good activity are pyranocycloartobiloxanthone A (PA), dihydro-artoindonesianin C, and pyranocycloartobiloxanthone B isolated from A. obtusus [27]. Nutritional compositions of the seeds have water, protein, carbohydrate, fat, calcium, phosphorus, iron, niacin, thiamine and vitamin C [9].…”

Influence of cultural practices on breast cancer risks, stage at presentation and outcome in a multi‑ethnic developing country (Review)

“…Other foods consist of the snake-head fish (ikan haruan), anchovies, meat, ginger, black pepper and a herb locally known as Kacip Fatimah [ Labisia pumila (LP )]. This herb has been found to have cytotoxic activity against the MCF-7 breast cancer cell line ( 30 , 31 ), prostate cancer cell lines ( 32 , 33 ) and melanoma cells ( 34 ). It has also been found to have anti-fungal and anti-inflammatory properties ( 30 ), including bronchodilatory properties ( 35 ).…”

Computational Analysis of Compounds From Ocimum Sanctum for Anticancer Activity Against Oral Squamous Cell Carcinoma

“…Ocimum sanctum "Return to Nature" is nowadays a trend [7]. Medicinal plants have been used since long time for curing several disease.…”

“…The phytochemicals present in the plant O. Sanctum were determined in two ways. One was through the literature survey of published research articles related to chemical constituents of O. sanctum [6][7][8][9][10][11][12][13][14][15] and the other one by querying phytochemical databases. Along with this, Dr. Duke's Phytochemical and Ethnobotanical Databases of the United States Department of Agriculture [16] which provided the indepth knowledge regarding the phytochemicals, as well as bioactivity of the plant, was also used for collecting the data.…”