Aspectos epidemiológicos, clínicos e anatomopatológicos do linfoma folicular em cães

Mazaro, Renata Dalcol; Rizkallah, Isis P. J; Luz, Flávia Serena da; Lorensetti, Douglas Miotto; Cogliati, Bruno; Fighera, Rafael A.

doi:10.1590/1678-5150-pvb-5286

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…O diagnóstico de linfoma de células T nasal foi realizado com base nos achados histopatológicos e confirmado através da imuno-histoquímica. Os linfomas em caprinos são considerados incomuns [15] e geralmente acometem animais de meia idade ou idosos [12]. Entretanto, Kiser & Löhr [8] descreveram casos da neoplasia em animais jovens, conforme observado nesse caso, onde o animal apresentava 1 ano de idade.…”

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T-cell Lymphoma in the Nasal Cavity in Goat

Firmino

Borges

Silveira³

et al. 2023

Acta Scientiae Vet.

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Background: Lymphomas are considered uncommon in goats, being the multicentric form with the highest number of cases for the species. Primary intranasal lymphomas are often diagnosed in dogs, cats, and humans. In the literature, there is only a description of a multicentric case involving the frontal sinuses and mucosa of the nasal cavity in a goat; therefore, it is important to describe unusual cases of this disease for the inclusion of new clinical and pathological characteristics in the ruminant clinic medicine. The objective of this work is to describe a case of T-cell lymphoma in the nasal cavity of a young goat.Case: The animal had dyspnea and respiratory noise for 15 days. Clinical examination showed nodulation in the right nasal cavity associated with serosanguinous secretion. Tracheostomy was performed; however, after 30 days the animal was euthanized. A sagittal plane of the head showed a pinkish-gray mass in the right and left nasal cavity, with a smooth, multilobulated surface, smooth adhering to the rostral portion of the dorsal concha and occluding the dorsal nasal meatus. Submandibular lymph nodes were slightly enlarged. Histopathological examination of the nasal cavity revealed a non-encapsulated, poorly delimited and ulcerated tumor composed of round cells arranged in a mantle supported by a discrete fibrovascular stroma extending the mucosa and lamina propria. Cells were round with sparse, eosinophilic and poorly delimited cytoplasm. Nuclei varied from round to elongated with condensed chromatin and evident nucleoli. Occasionally, aberrant nuclei, reniform shape and multinucleated cells were seen. Pleomorphism was moderate characterized by anisocytosis and anisocariosis. Typical and atypical mitosis were frequent (0-4 per field of highest magnification [400x]). Amidst the neoplasm, there were multifocal areas of necrosis and hemorrhage associated with a mild lymphocytic inflammatory infiltrate. Immunohistochemistry showed positive immunostaining for Vimentin antibodies and CD3, and negative for pan CK and CD20.Discussion: The lymphomas immunophenotyping is little used when it comes to farm animals, and there are few studies that use this technique for the definitive diagnosis of these neoplasms for small ruminants. The use of this technique must be considered in each case, in order to determine the pathogenesis, the accurate diagnosis and the origin of the neoplastic lymphocytes. In goats, T-cell lymphomas are the most diagnosed, although cases of multicentric B-cell lymphomas with ocular involvement have been diagnosed. In view of the clinical picture of the case described, infectious rhinitis already described in goats, such as aspergillosis and protothecosis, should be included as differential diagnoses. However, the anatomopathological findings facilitate the direction of the diagnosis, since infectious rhinitis presents as nodules / ulcerated masses or focal areas of necrosis associated with purulent secretion and in the histopathological examination it is possible to observe the intralesional etiological agents. In addition, the enzootic ethmoidal tumor must be included, as it has similar clinical signs and affects young animals, but they are adenomas/adenocarcinomas that affect the ethmoidal nasal shells induced by a retrovirus. Lymphomas in the caprine species are rare in the Northeastern semi-arid, but that in the present diagnostic routine occasionally occurs, being important the first description of its nasal shape for its inclusion in the differential diagnoses of diseases that present with clinical obstruction and dyspnea for the species. Keywords: hematopoietic neoplasia, immunophenotyping, lymphocytes, dyspnea.Descritores: neoplasia hematopoietica, imunofenotipagem, linfócitos, dispneia.Título: Linfoma de células T na cavidade nasal de caprino.

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Section: Discussionunclassified

T-cell Lymphoma in the Nasal Cavity in Goat

Firmino

Borges

Silveira³

et al. 2023

Acta Scientiae Vet.

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Remissão total de linfoma multicêntrico em cão com o protocolo Madison-Wisconsin: Relato de caso

Lima

Silva

Araújo

et al. 2021

RSD

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O linfoma é um distúrbio do sistema hematopoiético cuja etiologia envolve a proliferação desordenada de células linfóides, no qual o linfoma multicêntrico é caracterizado pelo aumento generalizado dos linfonodos. O protocolo Madison-Wisconsin é uma das poliquimioterapias mais utilizadas no tratamento de linfomas multicêntrico em cães, sendo constituída pelos fármacos ciclofosfamida, doxorrubicina, vincristina e prednisona, e administrados de forma alternada ao longo de 19 semanas. O presente trabalho teve como objetivo relatar a eficiência do protocolo terapêutico Madison-Wisconsin na remissão total de um linfoma multicêntrico em um cão. O animal atendido foi um cão da raça Bulldog Francês, que apresentava aumento dos linfonodos submandibulares, pré-escapulares, axilares, inguinais e poplíteos e, ao exame físico, o aumento em região mesogástrica sugeriu esplenomegalia. O exame citológico dos linfonodos submandibular e poplíteo foi compatível com linfoma. No exame ultrassonográfico detectou-se aumento acentuado do baço e fígado, caracterizando o quadro de hepatoesplenomegalia. No ecodopplercardiograma foi possível observar um aumento no átrio esquerdo. Houve acompanhamento hematológico do paciente durante tratamento quimioterápico e ao longo do curso terapêutico o animal apresentou alterações no hemograma, como trombocitose e neutropenia, o que requereu um tratamento adicional. No exame bioquímico, houve aumento da ALT. Após o término da quimioterapia o animal apresentou remissão total da neoplasia demonstrando o sucesso terapêutico do protocolo de Madison-Wisconsin sobre o linfoma.

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Aspectos epidemiológicos, clínicos e anatomopatológicos do linfoma folicular em cães

Cited by 2 publications

References 20 publications

T-cell Lymphoma in the Nasal Cavity in Goat

T-cell Lymphoma in the Nasal Cavity in Goat

Remissão total de linfoma multicêntrico em cão com o protocolo Madison-Wisconsin: Relato de caso

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