“…In this area, the number of promising biomedical materials is rapidly growing, mainly, to avoid the occurrence of implant failure and for better performance. Among the materials developed, metals and alloys such as new generation of Ti alloys, NiTi shape memory alloys, metallic glasses and porous metals [5][6][7], engineering ceramics including alumina-zirconia composites, oxidized zirconium and nonoxide ceramics [8,9], and polymeric materials such as UHMWPE-fiberreinforced high density polyethylene combined with a surface of UHMWPE, poly-ether-ether-ketone (PEEK), carbon fiber-reinforced PEEK (CFR-PEEK) [10][11][12][13][14][15][16], are believed to be high potential materials in orthopedics. On the other hand, implant design modifications are always carried out (from simple design to complex shape similar to biological organs) to prevent any failure response.…”