Corrosion behavior of Ti–39Nb alloy for dentistry

Fojt, Jaroslav; Joska, Luděk; Málek, Jaroslav; Šefl, V.

doi:10.1016/j.msec.2015.07.029

Cited by 29 publications

(15 citation statements)

References 49 publications

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“…This was exactly what we observed in all porous scaffolds, where there was a large number of cells growing and adhering to the scaffolds only 24 hours after cell seeding. This fact is extremely important and desirable in the osseointegration process, since clinical success of the implants is related to rapid osseointegration [ 43 ], thus decreasing the chances of failure due to bacteria and other etiological agents that may be related to implant failure. We attributed the success of cell adhesion and spreading to the interconnected pores present on the scaffold biomaterial which allowed greater anchoring of the cells.…”

Section: Discussionmentioning

confidence: 99%

Influence of Titanium Alloy Scaffolds on Enzymatic Defense against Oxidative Stress and Bone Marrow Cell Differentiation

Rodrigues

Zutin

Sartori

et al. 2020

International Journal of Biomaterials

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Studies have been directed towards the production of new titanium alloys, aiming for the replacement of Ti-6 Aluminium-4 Vanadium (TiAlV) alloy in the future. Many mechanisms related to biocompatibility and chemical characteristics have been studied in the field of implantology, but enzymatic defenses against oxidative stress remain underexplored. Bone marrow stromal cells have been explored as source of cells, which have the potential to differentiate into osteoblasts and therefore could be used as cells-based therapy. The objective of this study was to evaluate the activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in porous scaffolds of Ti-6 Aluminium-4 Vanadium (TiAlV), Ti-35 Niobium (TiNb), and Ti-35 Niobium-7 Zirconium-5 Tantalum (TiNbZrTa) on mouse bone marrow stromal cells. Porous titanium alloy scaffolds were prepared by powder metallurgy. After 24 hours, cells plated on the scaffolds were analyzed by scanning electron microscopy (SEM). The antioxidant enzyme activity was measured 72 hours after cell plating. Quantitative real time PCR (qRT-PCR) was performed after 3, 7, and 14 days, and Runx2 (Runt-related transcription factor2) expression was evaluated. The SEM images showed the presence of interconnected pores and growth, adhesion, and cell spreading in the 3 scaffolds. Although differences were noted for SOD and CAT activity for all scaffolds analyzed, no statistical differences were observed (p>0.05). The osteogenic gene Runx2 presented high expression levels for TiNbZrTa at day 7, compared to the control group (TiAlV day 3). At day 14, all scaffolds had more than 2-fold induction for Runx2 mRNA levels, with statistically significant differences compared to the control group. Even though we were not able to confirm statistically significant differences to justify the replacement of TiAlV regarding antioxidant enzymes, TiNbZrTa was able to induce faster bone formation at early time points, making it a good choice for biomedical and tissue bioengineering applications.

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Section: Discussionmentioning

confidence: 99%

Influence of Titanium Alloy Scaffolds on Enzymatic Defense against Oxidative Stress and Bone Marrow Cell Differentiation

Rodrigues

Zutin

Sartori

et al. 2020

International Journal of Biomaterials

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“…Compared to cp-Ti, it has significantly more negative corrosion potential and slightly higher exchange current density. In the case of a binary Ti-Nb alloy exhibiting similar behaviour, under these conditions, the electrochemical response is given by niobium [59]. It is apparent from the surface analysis that in the oxide layer of most alloys, compared to the default state, the concentration of niobium increases during exposure.…”

Section: Discussionmentioning

confidence: 99%

Mechanical properties, corrosion behaviour and biocompatibility of TiNbTaSn for dentistry

Hybášek

Fojt

Málek

et al. 2020

Mater. Res. Express

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Titanium and the alloy Ti-6Al-4V are standard in implantology, despite the fact that the alloys may suffer from biomechanical incompatibility. The appropriate solution is the use of titanium β-alloys with a low modulus of elasticity and high strength. An additional advantage of these alloys is improved corrosion behaviour in environments that may contain fluoride ions, i.e. the oral cavity. Ti-25Nb-4Ta-(X)Sn alloys, where X is 4, 6, 8 and 10 weight per cent, were prepared. The phase composition, ultimate tensile strength, yield strength, Young modulus, elongation and hardness were measured. The corrosion behaviour in physiological saline, acidified physiological saline with and without the fluoride ions, was determined using, potentiodynamic polarization and electrochemical impedance spectroscopy. Bioactivity was predicted on the base of exposure in the simulated body fluid extended by impedance detection of the Ca/P layer formation. From the point of view of mechanical properties, alloys with a higher tin content are ideal for load-bearing applications. The corrosion resistance of these alloys in physiological saline is similar to titanium and significantly higher in the fluoride ions containing environment. The bioactivity test -exposure in SBF has shown quite identical results of the studied alloys and titanium, both in terms of kinetics and total composition of precipitated calciumphosphate layer. Possible cytotoxicity effects were excluded by the exposure with murine fibroblasts. This study describes the mechanical properties and corrosion resistance in non-fluoride and fluoride containing media, predicts bioactivity and verifies non-cytotoxicity of new titanium alloys and demonstrates that they are a suitable substitute for currently the most widely used alloys (Ti-6Al-4V, Ti-6Al-7Nb) in terms of both mechanical properties and corrosion resistance for dental implants.

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“…Electrochemistry is frequently used to analyze corrosion resistance [35,52,53], where it determines that a material with better electrochemical properties and a higher electrical potential will not be easily oxidized. Thus, such a material will not corrode easily after being implanted into the human body, which enhances the feasibility of in vivo application of the material [54].…”

Section: Discussionmentioning

confidence: 99%

“…Corrosion resistance has also been the focus of recent studies, as materials used in dental implants face the unique problem of contact with fluoride ions from dental treatment products. Fluorides can cause destruction of the inert layer, which substantially increases the corrosion rate of the implant [35]. In previous studies, researchers have used various materials and methods such as a mechanical-resistant bioactive layer, a plasma spray, a sol-gel, electrochemical deposition techniques, acid-etching, and anodic oxidation on the surface of the materials to improve their antibacterial properties, corrosion resistance, and biocompatibility [25,36,37].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties and Corrosion Resistance of the Newly Developed Biomaterial, Ti–12Nb–1Ag Alloy

Chao

Chiu

et al. 2017

Metals

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Currently, the development of biomaterials has focused on having a low Young's modulus, biocompatibility, corrosion resistance, and antibacterial properties. Ti-Nb alloys have higher research value due to their excellent corrosion resistance and low Young's modulus. In recent years, the antibacterial properties of materials have been enhanced by the addition of Ag and Cu. Therefore, the corrosion resistance and antibacterial properties of the Ti-12Nb-1Ag alloy formulated in the current study were investigated and compared to those of commonly used Ti alloys, G2 pure Ti (ASTM B348 CP Grade 2), and Ti-6Al-4V, via electrochemical and E. coli antibacterial tests. Meanwhile, we also carried out a microstructural analysis to investigate the composition of the alloy. The results were as follows: (1) The electrochemical test demonstrated that Ti-12Nb-1Ag had a higher corrosion resistance than Ti-6Al-4V, which is similar to the properties of pure Ti. (2) The E. coli antibacterial test demonstrated that the sterilization rate of Ti-12Nb-1Ag was higher than that of the Ti-6Al-4V alloy and pure Ti. (3) The microstructural analysis revealed that Ti-12Nb-1Ag had an acicular martensite structure, with nano-Ag precipitates observed. Based on the results of the E. coli antibacterial test and the principles of sterilization of nano-precipitates and Ag, we inferred that the nano-Ag precipitates of Ti-12Nb-1Ag enhanced the antibacterial properties of the newly developed biomaterial, which is, namely, the Ti-12Nb-1Ag alloy.

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Corrosion behavior of Ti–39Nb alloy for dentistry

Cited by 29 publications

References 49 publications

Influence of Titanium Alloy Scaffolds on Enzymatic Defense against Oxidative Stress and Bone Marrow Cell Differentiation

Influence of Titanium Alloy Scaffolds on Enzymatic Defense against Oxidative Stress and Bone Marrow Cell Differentiation

Mechanical properties, corrosion behaviour and biocompatibility of TiNbTaSn for dentistry

Antibacterial Properties and Corrosion Resistance of the Newly Developed Biomaterial, Ti–12Nb–1Ag Alloy

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