Arg389Gly polymorphism of the human β1-adrenergic receptor in patients with nonfatal acute myocardial infarction

Iwai, Chikao; Akita, Hozuka; Kanazawa, Kenji; Shiga, Nobuyuki; Terashima, Masahiro; Matsuda, Yasuaki; Takai, Eiji; Miyamoto, Yoshitomo; Shimizu, Mariko; Kajiya, Teishi; Hayashi, Takatoshi; Yokoyama, Mitsuhiro

doi:10.1016/s0002-8703(03)00110-8

Cited by 50 publications

(31 citation statements)

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“…With respect to the two SNPs of β 1 ADR SNPs, the data for the Ser49Gly SNPs were not significantly different from those in a report from Sweden ( 27 ), and Arg389Gly also exhibited the same percentage of SNPs as reported by a Japanese group ( 14 ). In addition, the previously reported frequencies of two β 2 ADR SNPs, Gly16Arg and Glu27Gln, in a Japanese ( 28 ) and a Taiwanese ( 29 ) cohort were identical to the respective frequencies determined here.…”

Section: Discussionsupporting

confidence: 74%

“…A number of single nucleotide polymorphisms (SNPs) of β ADR subtypes have recently been reported to be positional candidate genes for cardiovascular diseases ( 12 , 13 ). For instance, the genotype of the Arg389Gly polymorphism in the human β 1 -adrenoceptor ( β 1 ADR) gene is reported to be associated with acute myocardial infarction ( 14 ) and hypertensive status ( 15 ), an association study ( 16 ) suggested that the gene encoding the β 2 -adrenoceptor ( β 2 ADR) was associated with essential hypertension; and the Arg64 allele of the β 3 -adrenoceptor ( β 3 ADR) gene is associated with obesity-related phenotypes ( 17 ), insulin resistance, hypertension, coronary artery disease and earlier age of onset of diabetes ( 18 ). The essential effects of the three β ADRs, however, need to be further clarified.…”

Section: Introductionmentioning

confidence: 99%

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Genetic Influences of .BETA.-Adrenoceptor Polymorphisms on Arterial Functional Changes and Cardiac Remodeling in Hypertensive Patients

et al. 2006

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Genetic Influences of .BETA.-Adrenoceptor Polymorphisms on Arterial Functional Changes and Cardiac Remodeling in Hypertensive Patients

et al. 2006

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“…5 A number of single-nucleotide polymorphisms (SNPs) of the bADR subtypes have recently been reported to be positional candidate genes for cardiovascular diseases (CVDs). 6 For instance, the genotypes of the Ser49Gly and Arg389Gly polymorphisms in the human b 1 ADR gene have been reported to be associated with arterial stiffness 7 and acute myocardial infarction, 8 respectively. An association study 9 has suggested that the gene encoding b 2 ADR is associated with essential hypertension, and the Arg64 allele of the b 3 ADR gene is associated with obesity-related phenotypes, insulin resistance, hypertension, coronary artery disease and earlier age of onset of diabetes.…”

Section: Introductionmentioning

confidence: 99%

β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease: a cohort study with hypertensive patients

et al. 2011

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Single-nucleotide polymorphisms (SNPs) of the b-adrenergic receptor (bADR) subtypes are related to hypertension and obesity. This hospital-based cohort study with hypertensive patients evaluated five bADR SNPs in association with cardiovascular events. The cohort included 357 hypertensive patients (male¼181; mean age¼61.5 ± 11.8 years) seen between January 1998 and June 2004. The SNPs (Ser49Gly and Arg389Gly for b 1 ADR; Gly16Arg and Glu27Gln for b 2 ADR; Trp64Arg for b 3 ADR) were identified by PCR. We used Kaplan-Meier curves to assess the prognostic effect of these SNPs on cardiovascular disease (CVD). The SNP frequencies were Ser/Ser:Ser/Gly:Gly/Gly¼243:104:10; Arg/Arg:Arg/Gly:Gly/Gly¼256:95:6; Gly/Gly:Gly/Arg:Arg/ Arg¼71:201:85; Gln/Gln:Glu/Gln¼308:49; and Trp/Trp:Trp/Arg:Arg/Arg¼265:89:3. A total of 17 stroke and 15 coronary artery disease cases were recorded. By Kaplan-Meier analysis, the Ser/Ser SNP in Ser49Gly (P¼0.0398), the Glu/Gln SNP in Glu27Gln (P¼0.0390) and the Trp/Trp SNP in Trp64Arg (P¼0.0132) were associated with lower event-free CVD survival (log-rank, Mantel-Cox model). A Cox proportional hazards model revealed that only the Trp/Trp SNP (P¼0.0321) and age (P¼0.0186) were independently related to lower event-free survival for CVD, adjusted for gender, diabetes, dyslipidemia, blood pressure, body mass index, medication and hypertensive complications. Combination Kaplan-Meier analysis of these three positive SNPs indicated a higher frequency of CVD among patients with the combination of Ser/Ser in Ser49Gly of b 1 , Glu/Gln in Glu27Gln of b 2 and Trp/Trp in Trp64Arg of b 3 (P¼0.0209). These three SNPs, especially the Trp64Arg SNP of b 3 ADR, might be risk factors for CVD in hypertensive patients.

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“…Опубликованы немногочисленные данные по изучению ассоциации между клиническим течением хронической сердечной недостаточности (ХСН) и полиморфизмом генов, кодирующих β1-АР и β2-АР [12][13][14]. Так, L. Covolo et al [15] на европей-ской популяции и S. Nonen et al [16] на японской популяции не обнаружили ассоциативных взаимо-связей между полиморфизмом Arg389Glu гена ADRB1 и риском развития ХСН.…”

Section: Discussionunclassified

Polymorphic Variants of Genes Coding Sympathoadrenal System Influence on Phenotype of Patients With Hypertrophic Cardiomyopathy

Комиссарова¹,

Ниязова²,

Чакова³

et al. 2015

Ross. kardiol. ž.

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Цель. Выявить ассоциации полиморфных вариантов генов, кодирующих белки симпатоадреналовой системы (ADRB1 и ADRB2) с клиническим феноти-пом заболевания с учетом пола и возраста пациентов с ГКМП. Материал и методы. Проведен анализ клинико-демографических и инстру-ментальных данных 275 пациентов с диагнозом ГКМП (97 женщин и 178 муж-чин, в возрасте от 17 до 70 лет, медиана возраста женщин 51 год, мужчин -44 г). Все показатели оценивали на момент включения пациентов в исследова-ние. Амплификацию полиморфного участка исследуемого гена осуществляли методом ПЦР с последующим рестрикционным анализом. Результаты. Однофакторный анализ выявил, что наличие фибрилляции пред-сердий (ФП) ассоциировано с полиморфизмом Arg389gly гена АDRB1 (p=0,028). сердечная недостаточность высокого ФК II-III показала тенденцию к ассоциации с полиморфизмом Arg389gly гена АDRB1 (p=0,060). Многофак-торный анализ показал, что наличие эпизодов неустойчивой желудочковой тахикардии (НЖТ) чаще ассоциировалось с пациентами -носителями гетеро-зиготного генотипа GC гена ADRB2 (полиморфизм gln27glu) (ОШ 1,76; 1,02-3,06; 95% Ди) Наличие ФП встречалось реже у носителей гетерозиготного генотипа gC гена ADRB1 (полиморфизм Arg389gly) (ОШ 0.39 (0,17-0,82; 95% Ди) по сравнению с остальными генотипами. сердечная недостаточность высокого ФК II-III чаще определялась у пациентов -носителей генотипа gC гена ADRB2 (полиморфизм gln27glu) (ОШ 4,31; 1,08-29,03; 95% Ди). Заключение. Генотип gс полиморфизма гена ADRB2 (полиморфизм gln27glu) является наиболее неблагоприятным фактором, оказывающим вли-яние на такие клинические проявления ГКМП, как наличие высокого функцио-нального класса сердечной недостаточности, развитие жизнеугрожающих аритмий. Aim. To reveal the associations of polymorphic genes variants coding the proteins of sympathoadrenal system (ADRB1 and ADRB2) with clinical phenotype of the disease including age and gender of patients with HCMP. Material and methods. The analysis of clinical-demographic and instrumental data of 275 patients with the diagnosis of HCMP (97 women and 178 men, age 17 to 70 y. o., median age 51 y. and 44 y., resp.) was done. All parameters were assessed at the moment of the patients inclusion. Amplification of polymorphic area of the gene was done by PCR method with consequent restriction analysis. Results. Monofactor analysis revealed that atrial fibrillation (AF) is associated with polymorphism of Arg389gly gene АDRB1 (p=0,028). Heart failure of the higher FC II-III showed tendency to association with polymorphism Arg389gly gene АDRB1 (p=0,060). Multifactorial analysis showed that the presence of nonsustained ventricular tachycardia episodes (nVT) more often associated with the patientscarriers of heterozygous gC gene АDRB2 (polymorphism gln27glu) (OR 1,76; 1,02-3,06; 95% CI). AF was more rare in the carriers of heterozygous genotype of gC gene АDRB1 (polymorphism Arg389gly) (OR 0,39 (0,82; 95% CI) comparing to the normal genotypes. Heart failure of higher FC II-III more often was found in patients -carriers of gC gene АDRB1 (polym...

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Arg389Gly polymorphism of the human β1-adrenergic receptor in patients with nonfatal acute myocardial infarction

Cited by 50 publications

References 14 publications

Genetic Influences of .BETA.-Adrenoceptor Polymorphisms on Arterial Functional Changes and Cardiac Remodeling in Hypertensive Patients

Genetic Influences of .BETA.-Adrenoceptor Polymorphisms on Arterial Functional Changes and Cardiac Remodeling in Hypertensive Patients

β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease: a cohort study with hypertensive patients

Polymorphic Variants of Genes Coding Sympathoadrenal System Influence on Phenotype of Patients With Hypertrophic Cardiomyopathy

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