Genetic Influences of .BETA.-Adrenoceptor Polymorphisms on Arterial Functional Changes and Cardiac Remodeling in Hypertensive Patients

Yuan, Man; Ohishi, Mitsuru; Ito, Norihisa; Sugimoto, Ken; Takagi, Takashi; Terai, Minako; Katsuya, Tomohiro; Rakugi, Hiromi; Wu, Zonggui; Ogihara, Toshio

doi:10.1291/hypres.29.875

Cited by 16 publications

(9 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…21 We previously found an association between a genetic polymorphism in Ser49Gly of the b 1 ADR and aortic stiffness as measured by pulse wave velocity, and the Gly49Gly genotype showed a genetic association with nitroglycerin-induced hyperemia. 7 Although functional analysis is required, the Ser49Gly polymorphism of b 1 ADR might influence arterial functional changes. The Glu27Gln polymorphism of b 2 ADR has been identified by both electrocardiography and echocardiography to be significantly associated with left ventricular hypertrophy.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the TaqMan PCR assay as described previously was used to perform polymorphism analysis of the three bADRs, b 1 , b 2 and b 3 . 7 We detected two polymorphisms of b 1 ADR that result in serine/glycine (Ser49Gly) and arginine/glycine (Arg389-Gly) amino acid substitutions at residues 49 and 389, respectively. We also detected two polymorphisms of b 2 ADR that result in glycine/arginine (Gly16Arg) and glutamate/glutamine (Glu27Gln) amino acid substitutions at residues 16 and 27, respectively.…”

Section: Genotypingmentioning

confidence: 92%

“…5 A number of single-nucleotide polymorphisms (SNPs) of the bADR subtypes have recently been reported to be positional candidate genes for cardiovascular diseases (CVDs). 6 For instance, the genotypes of the Ser49Gly and Arg389Gly polymorphisms in the human b 1 ADR gene have been reported to be associated with arterial stiffness 7 and acute myocardial infarction, 8 respectively. An association study 9 has suggested that the gene encoding b 2 ADR is associated with essential hypertension, and the Arg64 allele of the b 3 ADR gene is associated with obesity-related phenotypes, insulin resistance, hypertension, coronary artery disease and earlier age of onset of diabetes.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease: a cohort study with hypertensive patients

et al. 2011

Self Cite

View full text Add to dashboard Cite

Single-nucleotide polymorphisms (SNPs) of the b-adrenergic receptor (bADR) subtypes are related to hypertension and obesity. This hospital-based cohort study with hypertensive patients evaluated five bADR SNPs in association with cardiovascular events. The cohort included 357 hypertensive patients (male¼181; mean age¼61.5 ± 11.8 years) seen between January 1998 and June 2004. The SNPs (Ser49Gly and Arg389Gly for b 1 ADR; Gly16Arg and Glu27Gln for b 2 ADR; Trp64Arg for b 3 ADR) were identified by PCR. We used Kaplan-Meier curves to assess the prognostic effect of these SNPs on cardiovascular disease (CVD). The SNP frequencies were Ser/Ser:Ser/Gly:Gly/Gly¼243:104:10; Arg/Arg:Arg/Gly:Gly/Gly¼256:95:6; Gly/Gly:Gly/Arg:Arg/ Arg¼71:201:85; Gln/Gln:Glu/Gln¼308:49; and Trp/Trp:Trp/Arg:Arg/Arg¼265:89:3. A total of 17 stroke and 15 coronary artery disease cases were recorded. By Kaplan-Meier analysis, the Ser/Ser SNP in Ser49Gly (P¼0.0398), the Glu/Gln SNP in Glu27Gln (P¼0.0390) and the Trp/Trp SNP in Trp64Arg (P¼0.0132) were associated with lower event-free CVD survival (log-rank, Mantel-Cox model). A Cox proportional hazards model revealed that only the Trp/Trp SNP (P¼0.0321) and age (P¼0.0186) were independently related to lower event-free survival for CVD, adjusted for gender, diabetes, dyslipidemia, blood pressure, body mass index, medication and hypertensive complications. Combination Kaplan-Meier analysis of these three positive SNPs indicated a higher frequency of CVD among patients with the combination of Ser/Ser in Ser49Gly of b 1 , Glu/Gln in Glu27Gln of b 2 and Trp/Trp in Trp64Arg of b 3 (P¼0.0209). These three SNPs, especially the Trp64Arg SNP of b 3 ADR, might be risk factors for CVD in hypertensive patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Genotypingmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease: a cohort study with hypertensive patients

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…Yuan et al studied 300 hypertensive subjects in observational fashion and noted a relationship between -adrenoreceptor polymorphisms and arterial stiffness and LVH. These studies suggest that the SNS decreases arterial distensibility and increases a number of processes that contribute to arterial stiffening [150].…”

Section: Sympathetic Nervous Systemmentioning

confidence: 89%

Actions of Selected Cardiovascular Hormones on Arterial Stiffness and Wave Reflections

Nichols

Epstein²

2009

CPD

View full text Add to dashboard Cite

The large conduit arteries of the thorax and abdomen are elastic while those in the arms and legs are muscular. Alterations in wall properties of elastic arteries occur over time and are usually permanent in nature; acute changes can, however, occur is response to a change in transmural pressure. Chronic alterations in properties of muscular arteries are minimal but changes (e.g vasoconstriction, vasodilation or tone) do occur in response to smooth muscle cell (SMC) stimulation. In general an increase in arterial stiffness (and wave reflection) increases systolic blood pressure (BP) and is detrimental while a decrease is beneficial. The augmentation in systolic BP increases left ventricular (LV) mass, wasted energy, tension-time index (TTI) and myocardial oxygen demand while the fall in diastolic BP decreases coronary artery perfusion causing a mismatch in ventricular/vascular coupling and an imbalance in the myocardial oxygen supply/demand ratio. Cardiovascular hormones such as renin, angiotensin, aldosterone, parathormone, sympathomimetic amines and endothelin induce vasoconstriction and increase arterial stiffness while insulin, thyroxine, testosterone, atrial natriuretic peptide (ANP), estrogen and nitric oxide (NO) have the opposite effect. The undesirable effects can be reversed with selected blocking agents. Vasodilator drugs have little direct active effect on large elastic arteries and unaugmented BP but can markedly reduce wave reflection amplitude and duration and augmentation index by decreasing stiffness of the muscular arteries and reducing transmission velocity of the reflected wave from the periphery to the heart. This decrease in amplitude and increase in travel time (or delay) of the reflected wave causes a generalized decrease in systolic BP, arterial wall stress, wasted LV energy and TTI.

show abstract

“…The analyses into various polymorphisms of hormones and diseases develop, and the relationship between adrenergic receptor polymorphisms and blood pressure was studied (37)(38)(39)(40)(41)(42). These reports (37)(38)(39)(40)(41) described that the effects of various adrenergic receptor polymorphisms on agonist-mediated vascular desensitization were different. The remaining study (42) examined the relationship between mental stress and adrenergic receptor genotypes, and described that increase of blood pressure depended on these genotypes.…”

mentioning

confidence: 99%

Focus on Masked Workplace Hypertension: The Next Step for Perfect 24-Hour Blood Pressure Control

Uno

Kario

2006

Hypertens Res

View full text Add to dashboard Cite

Genetic Influences of .BETA.-Adrenoceptor Polymorphisms on Arterial Functional Changes and Cardiac Remodeling in Hypertensive Patients

Cited by 16 publications

References 35 publications

β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease: a cohort study with hypertensive patients

β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease: a cohort study with hypertensive patients

Actions of Selected Cardiovascular Hormones on Arterial Stiffness and Wave Reflections

Focus on Masked Workplace Hypertension: The Next Step for Perfect 24-Hour Blood Pressure Control

Contact Info

Product

Resources

About