β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease: a cohort study with hypertensive patients

Iwamoto, Yoshihiro; Ohishi, Mitsuru; Yuan, Man; Tatara, Yuji; Kato, Nozomi; Takeya, Yasushi; Onishi, Masanori; Maekawa, Yoshihiro; Kamide, Kei; Rakugi, Hiromi

doi:10.1038/hr.2010.281

Cited by 23 publications

(13 citation statements)

References 22 publications

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“…Some clinical studies pointed on possible relationship between AH and Trp64Arg polymorphism [17,35,36], as well as relationship between this genotype and higher mortality among hypertensives [37]. In our study, we found an association of Trp64Arg carrier state with AH (p < 0.019).…”

Section: Discussionsupporting

confidence: 65%

An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances

Mirrakhimov

Kerimkulova

Lunegova

et al. 2011

Cardiovasc Diabetol

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BackgroundsB3 adrenoreceptors (ADRB3) are abundant in adipose tissue and play the role in its metabolism and lipolysis. Some variants of the ADRB3 gene may predispose subjects for the development obesity and metabolic abnormalities in the setting of modern sedentary lifestyle. ADRB3 gene polymorphism association with metabolic disturbances has never been studied before in the ethnic Kyrgyz population.AimTo study an association between Trp64Arg polymorphism of the ADRB3 and metabolic syndrome (MS) components in an ethnic Kyrgyz group.Materials and methods213 Ethnic Kyrgyz volunteers over the age of 30 were enrolled in the study. The assessment plan for each individual comprised of general physical and anthropometric exams as well as laboratory tests (glucose, lipid panel, insulin) and genotyping by Trp64Arg polymorphism of the ADRB3. MS diagnosis was consistent with modified ATP III criteria (2005). Logistic regression analysis was performed to test the potential independent association between Arg64 allele with obesity, abdominal obesity (AO) and arterial hypertension (AH).ResultsTrp64Arg polymorphism of the ADRB3 was assessed in 213 individuals (145 men, 68 women) aged 30-73 (mean age 50.7 ± 7.6). Arg64 allele frequency was 0.239; ADRB3 genotype distribution among participants was: Trp64 homozygotes 54.5%, Trp64Arg 43.2% and Arg64 homozygotes 2.3%. There was an association between Trp64Arg и Arg64Arg genotypes and higher BMI, WC and obesity frequency (p < 0.00009), AO (p < 0.01), type 2 diabetes mellitus (DM) (p < 0.005) and lower high density cholesterol (HDL-C) level (p < 0.03). The logistic regression analysis showed the correlation of the Arg64 allele with obesity (OR 3.159; 95% CI 1.789-5.577) and AO (OR 1.973; 95% CI 1.118-3.481). The association between Arg64 allele and AH lost its significance after adjustment for obesity.ConclusionArg64 allele of the ADRB3 gene in the studied group has an association with MS components such as obesity, AO and decreased HDL-C level.

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Section: Discussionsupporting

confidence: 65%

An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances

Mirrakhimov

Kerimkulova

Lunegova

et al. 2011

Cardiovasc Diabetol

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“…21 Cohort studies have shown rs4994 to be a genetic risk factor for cardiovascular disease in hypertensive patients. 22 However, the effect of rs4994 remains unclear. 23 Studies performed on Chinese Han individuals remain rare.…”

Section: Discussionmentioning

confidence: 99%

Association between single-nucleotide polymorphisms in six hypertensive candidate genes and hypertension among northern Han Chinese individuals

Wang

Zhang

et al. 2014

Hypertens Res

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Hypertension is one of the leading risk factors for mortality. The renin-angiotensin-aldosterone system (RAAS) is a potent and powerful mediator in the homeostasis of hypertension. Here, the association between six candidate genes, renin, adrenoceptor β3, angiotensinogen, aldosterone synthase, angiotensin II receptor type 1 and angiotensin II receptor type 2, that are related to RAAS and essential hypertension (EH) was evaluated and explored in northern Chinese Han individuals. A case-control study including 1090 EH cases and 700 controls was performed. Eight single-nucleotide polymorphisms (SNPs), rs699, rs4762, rs5707, rs5186, rs4994, rs1799998, rs5193 and rs5194, located in the six genes were genotyped with TaqMan real-time PCR method. Statistical analysis software (SPSS 17.0) was used for descriptive statistics and association analyses. Among the six genes related to RAAS, the frequencies of rs4994 (ADRB3) and rs5194 (AGTR2) were found to be significantly different between the EH cases and controls (P < 0.05). Logistic regression analyses adjusted for covariates showed rs4994 to be closely associated with EH under the recessive (P = 0.019, odds ratio (OR) = 0.373, 95% confidence interval (CI) 0.163-0.851) and homozygous (P = 0.028, OR = 0.394, 95% CI 0.172-0.903) models. The association was also significantly close in the male subset (P < 0.05). Significant association was also observed between rs1799998 (CYP11B2) and EH (P < 0.05) in the dominant, additive and allelic models. These data demonstrated that ADRB3 rs4994 and CYP11B2 rs1799998 were significantly closely associated with EH in northern Han Chinese individuals. The CC of rs4994 and CC or C allele of rs1799998 might be protective genetic factors of hypertension.

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“…These functions render 2 -AR an important target for cardiovascular disease (CVD) therapy [15,22,23]. Interestingly, studies reported 2 -AR dysfunction to be implicated in the pathogenesis of several CVD including hypertension [24][25][26][27], coronary heart disease [13,23], idiopathic dilated cardiomyopathy [28], congestive heart failure [29,30], idiopathic ventricular arrhythmias [31], and sudden cardiac death [32].…”

Section: Introductionmentioning

confidence: 99%

Beta₂-Adrenergic Receptor Gene Polymorphisms in Egyptian Patients with Acute Myocardial Infarction

Toraih

Hussein

Badran

2014

Advances in Molecular Biology

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Background. Beta2-adrenergic receptor (ADRB2) gene polymorphisms, Arg16Gly and Gln27Glu, have been implicated in the pathogenesis of cardiovascular diseases. The aim of this study was to determine the association of these two polymorphisms with the risk of myocardial infarction (MI) in the Egyptian population.Methods. Blood samples were collected from 68 MI patients and 75 healthy controls. They were assessed for the presence of cardiovascular risk factors and genotyped for the Arg16Gly (rs1042713) and Gln27Glu (rs1042714) polymorphisms using allelic-discrimination polymerase chain reaction.Results. There is no significant difference in genotype and allele frequencies at codon 16 between MI patients and controls (P=0.919). However, at codon 27, MI risk was higher in Gln27homozygous participants than in Glu27carriers (P=0.045). The haplotype frequency distribution showed significant difference among cases and controls (P=0.002); homozygotes for Gly16/Gln27haplotype were more susceptible to MI than Gly16/Glu27carriers. Patients with Arg16/Gln27haplotype had higher serum total cholesterol levels (P<0.05) and lower frequency of diabetes in MI patients (P<0.01). However, both Glu27genotypes and haplotype showed lower frequency of hypertension (P<0.001).Conclusions. Our findings suggested that theADRB2gene polymorphisms may play an important role in susceptibility of MI among Egyptian population.

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β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease: a cohort study with hypertensive patients

Cited by 23 publications

References 22 publications

An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances

An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances

Association between single-nucleotide polymorphisms in six hypertensive candidate genes and hypertension among northern Han Chinese individuals

Beta₂-Adrenergic Receptor Gene Polymorphisms in Egyptian Patients with Acute Myocardial Infarction

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β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease: a cohort study with hypertensive patients

Cited by 23 publications

References 22 publications

An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances

An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances

Association between single-nucleotide polymorphisms in six hypertensive candidate genes and hypertension among northern Han Chinese individuals

Beta2-Adrenergic Receptor Gene Polymorphisms in Egyptian Patients with Acute Myocardial Infarction

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Beta₂-Adrenergic Receptor Gene Polymorphisms in Egyptian Patients with Acute Myocardial Infarction