Beta<sub><b>2</b></sub>-Adrenergic Receptor Gene Polymorphisms in Egyptian Patients with Acute Myocardial Infarction

Toraih, Eman A.; Hussein, Mohammad; Badran, Dahlia I.

doi:10.1155/2014/471635

Cited by 12 publications

(13 citation statements)

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“…The Gly49Gly variant is extremely rare and its lower frequency was also reported in previous studies within various ethnic populations (22)(23)(24)(25). Furthermore, in good accordance with our data, Gly16-β 2 AR and Gly16Gly-β 2 AR were reported as the most prominent alleles and genotypes among different ethnic populations (White and Black Americans, Chinese and Egyptian populations) [26,27].…”

Section: Discussionsupporting

confidence: 92%

Association of β1 and β2-adrenoceptor Polymorphisms With the Demand of Inotropic Catecholamine Support Following Coronary Artery Bypass Grafting in Iranian Population

Eslami

Ghafari

Hassani

et al. 2020

Preprint

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Background: Hemodynamic instability is a common complication in the first hours following cardiac surgery and inotropic catecholamine support is an acceptable treatment strategy for its management. β1 and β2-adrenoceptors (β1 and β2 AR) are mediated the positive inotropic and chronotropic responses of the heart to catecholamines. Previous evidence has suggested an association between β1 and β2AR polymorphisms and cardiac response and change in receptor signaling. The aim of this study was evaluating the relationship between β1 and β2AR polymorphisms with demand of catecholamine inotropic support among coronary artery bypass grafting (CABG) patients.Methods: One hundred ninety-eight consecutive patients who underwent CABG with cardiopulmonary bypass were included in this study. We assessed hemodynamic parameters, dose and duration of inotropic support according to β1 and β2AR genotypes in post-operative period. DNA genotyping were assessed through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and PCR genotyping results were confirmed by direct DNA sequencing. Results: The our results indicated that patients carrying one or two alleles of the Arg389-β1AR variant required significantly shorter inotropic support time compared with patients homozygous for the Gly389-β1AR (p=0.003). Finally, neither β1AR polymorphisms nor Arg16Gly-β2AR polymorphism are associated with catecholamines-induced hemodynamic effects.Conclusion: These findings suggest that genetic variability in the β1 and β2AR polymorphisms may not be a major determinant of cardiac responses to catecholamine treatment in Iranian population. However, larger scale studies with different ethnicities are needed for confirmation.

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Section: Discussionsupporting

confidence: 92%

Association of β1 and β2-adrenoceptor Polymorphisms With the Demand of Inotropic Catecholamine Support Following Coronary Artery Bypass Grafting in Iranian Population

Eslami

Ghafari

Hassani

et al. 2020

Preprint

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“…Genotype, allele frequencies and carriage rate were calculated using SPSS as described previously . Differences in genotypic and allelic distribution of GC gene polymorphisms between patients and controls were determined by Pearson's chi‐square ( χ 2 ).…”

Section: Methodsmentioning

confidence: 99%

Association of group‐specific component exon 11 polymorphisms with bronchial asthma in children and adolescents

et al. 2019

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Several studies have investigated the association of Group-specific Component (GC) gene, also known as vitamin D-binding protein (VDBP), and various respiratory disorder susceptibility with conflicting results. In this sense, we aimed to investigate whether rs7041 and rs4588 variants confer susceptibility to bronchial asthma in a sample of an Egyptian population and to elucidate by in silico analysis the structural and functional impact of these variants. Group-specific Component polymorphisms rs7041 and rs4588 were genotyped in 192 Egyptian children and adolescents (96 with asthma and 96 healthy controls) by TaqMan single nucleotide polymorphism genotyping assay. The rs7041 GG genotype showed a significantly elevated frequency among patients under codominant, dominant, recessive and allelic models where the patient group had greater carriage rate of G allele [OR 2.15, CI 95% (1.32-3.50; P = 0.002)], while rs4588 CA and AA genotypes were found to be protective genotypes with controls showing a greater carriage rate of A allele [OR 0.52, CI 95% (0.30 -0.90; P = 0.02)]. Three haplotype allele combinations were identified with frequencies of GC (44.3%), TC (31.3%) and TA (24.5%) in the total study population. GC haplotype was shown to be more frequent in controls, while TC and TA haplotypes were more predominant in the patient group. Only rs7041 variant showed a significant association with family history and pubertal status. In conclusion, both study GC variants could be implicated in childhood bronchial asthma pathogenesis; rs7041 GG genotype and G allele increased asthma risk while rs4588 AA genotype and A allele conferred protection in the study population.

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“…Statistical analysis was performed using PCORD v.5.0, R programming language and the “ Statistical Package for the Social Sciences (SPSS) for windows ” software, version 22. Allele and genotype frequencies and carriage rate were calculated as previously described [ 31 ]. The Hardy-Weinberg equilibrium was estimated using the Online Encyclopedia for Genetic Epidemiology (OEGE) software ( http://www.oege.org/software/hwe-mr-calc.shtml ) and tested for goodness of fit by chi square test.…”

Section: Methodsmentioning

confidence: 99%

Structure and functional impact of seed region variant in MIR-499 gene family in bronchial asthma

Toraih¹,

Hussein²,

Ageeli³

et al. 2017

Respir Res

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BackgroundSmall non-coding RNAs (microRNAs) have been evolved to master numerous cellular processes. Genetic variants within microRNA seed region might influence microRNA biogenesis and function. The study aimed at determining the role of microRNA-499 (MIR-499) gene family polymorphism as a marker for susceptibility and progression of bronchial asthma and to analyze the structural and functional impact of rs3746444 within the seed region.MethodsGenotyping for 192 participants (96 patients and 96 controls) in the discovery phase and 319 subjects (115 patients and 204 controls) in the replication phase was performed via Real Time-Polymerase Chain Reaction technology. Patients underwent the methacholine challenge test and biochemical analysis. Gene structural and functional analysis, target prediction, annotation clustering, and pathway enrichment analysis were executed. Predicted functional effect of rs37464443 SNP was analyzed.ResultsmiR-499 gene family is highly implicated in inflammation-related signaling pathways. Rs374644 (A > G) in MIR499A and MIR499B within the seed region could disrupt target genes and create new genes. The G variant was associated with high risk of developing asthma under all genetic association models (G versus A: OR = 3.27, 95% CI = 2.53–4.22; GG versus AA: OR = 9.52, 95% CI = 5.61–16.5; AG versus AA: OR = 2.13, 95% CI = 1.24–3.46; GG + AG versus AA: OR = 4.43, 95% CI = 2.88–6.82). GG genotype was associated with poor pre-bronchodilator FEV1 (p = 0.047) and the worst bronchodilator response after Salbutamol inhalation, represented in low peaked expiratory flow rate (p = 0.035).ConclusionsmiR-499 rs3746444 (A > G) polymorphism was associated with asthma susceptibility and bronchodilator response in Egyptian children and adolescents. Further functional analysis is warranted to develop more specific theranostic agents for selecting targeted therapy.Electronic supplementary materialThe online version of this article (10.1186/s12931-017-0648-0) contains supplementary material, which is available to authorized users.

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Beta₂-Adrenergic Receptor Gene Polymorphisms in Egyptian Patients with Acute Myocardial Infarction

Cited by 12 publications

References 106 publications

Association of β1 and β2-adrenoceptor Polymorphisms With the Demand of Inotropic Catecholamine Support Following Coronary Artery Bypass Grafting in Iranian Population

Association of β1 and β2-adrenoceptor Polymorphisms With the Demand of Inotropic Catecholamine Support Following Coronary Artery Bypass Grafting in Iranian Population

Association of group‐specific component exon 11 polymorphisms with bronchial asthma in children and adolescents

Structure and functional impact of seed region variant in MIR-499 gene family in bronchial asthma

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Beta2-Adrenergic Receptor Gene Polymorphisms in Egyptian Patients with Acute Myocardial Infarction

Cited by 12 publications

References 106 publications

Association of β1 and β2-adrenoceptor Polymorphisms With the Demand of Inotropic Catecholamine Support Following Coronary Artery Bypass Grafting in Iranian Population

Association of β1 and β2-adrenoceptor Polymorphisms With the Demand of Inotropic Catecholamine Support Following Coronary Artery Bypass Grafting in Iranian Population

Association of group‐specific component exon 11 polymorphisms with bronchial asthma in children and adolescents

Structure and functional impact of seed region variant in MIR-499 gene family in bronchial asthma

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Beta₂-Adrenergic Receptor Gene Polymorphisms in Egyptian Patients with Acute Myocardial Infarction