An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances

Abstract

BackgroundsB3 adrenoreceptors (ADRB3) are abundant in adipose tissue and play the role in its metabolism and lipolysis. Some variants of the ADRB3 gene may predispose subjects for the development obesity and metabolic abnormalities in the setting of modern sedentary lifestyle. ADRB3 gene polymorphism association with metabolic disturbances has never been studied before in the ethnic Kyrgyz population.AimTo study an association between Trp64Arg polymorphism of the ADRB3 and metabolic syndrome (MS) components in an ethnic Kyrgyz group.Materials and methods213 Ethnic Kyrgyz volunteers over the age of 30 were enrolled in the study. The assessment plan for each individual comprised of general physical and anthropometric exams as well as laboratory tests (glucose, lipid panel, insulin) and genotyping by Trp64Arg polymorphism of the ADRB3. MS diagnosis was consistent with modified ATP III criteria (2005). Logistic regression analysis was performed to test the potential independent association between Arg64 allele with obesity, abdominal obesity (AO) and arterial hypertension (AH).ResultsTrp64Arg polymorphism of the ADRB3 was assessed in 213 individuals (145 men, 68 women) aged 30-73 (mean age 50.7 ± 7.6). Arg64 allele frequency was 0.239; ADRB3 genotype distribution among participants was: Trp64 homozygotes 54.5%, Trp64Arg 43.2% and Arg64 homozygotes 2.3%. There was an association between Trp64Arg и Arg64Arg genotypes and higher BMI, WC and obesity frequency (p < 0.00009), AO (p < 0.01), type 2 diabetes mellitus (DM) (p < 0.005) and lower high density cholesterol (HDL-C) level (p < 0.03). The logistic regression analysis showed the correlation of the Arg64 allele with obesity (OR 3.159; 95% CI 1.789-5.577) and AO (OR 1.973; 95% CI 1.118-3.481). The association between Arg64 allele and AH lost its significance after adjustment for obesity.ConclusionArg64 allele of the ADRB3 gene in the studied group has an association with MS components such as obesity, AO and decreased HDL-C level.

Association between single-nucleotide polymorphisms in six hypertensive candidate genes and hypertension among northern Han Chinese individuals

“…19 Trp64Arg polymorphism has been reported to be associated with obesity, central obesity, weight gain, insulin resistance, type 2 diabetes mellitus, hypereruricemia 20 and metabolic syndrome. 21 Cohort studies have shown rs4994 to be a genetic risk factor for cardiovascular disease in hypertensive patients. 22 However, the effect of rs4994 remains unclear.…”

Effect of Zingiber officinale Supplementation on Obesity Management with Respect to the Uncoupling Protein 1 ‐3826A>G and ß3‐adrenergic Receptor Trp64Arg Polymorphism

“…The other limitation of this study was that the number of subjects in the genotype subgroups of the Trp64Arg polymorphism might not be sufficient to completely identify the effect of gene–intervention interaction on weight loss or other parameters, particularly that we did not find the Arg64Arg polymorphism in our study population. However, its frequency has often been reported to be low in other populations (Mirrakhimov et al ., ; Tsunekawa et al ., ). Moreover, because there was no other intervention such as weight‐lowering diet across the study, it might be better to design an intervention with higher dose of ginger powder (i.e., 3 g) to reach more efficacy of intervention, just as a suggestion for future researches, because it is a safe herbal medicine according to existing data and also the FDA's report on its safety (Li et al ., ).…”

Effects of lifestyle intervention on weight and metabolic parameters in patients with impaired glucose tolerance related to beta‐3 adrenergic receptor gene polymorphism Trp64Arg(C/T): Results from the Japan Diabetes Prevention Program

“…The present study also showed a gene–treatment interaction on HDL‐C levels. The Arg64 allele was cross‐sectionally associated with a decreased HDL‐C level in obese Japanese people and a Kyrgyz population, although a few studies described conflicting data – no association with HDL‐C or association with higher HDL‐C levels was found in Caucasian‐Brazilian patients with type 2 diabetes. An increase of HDL‐C levels is important for preventing the development of diabetes mellitus and atherosclerosis.…”