Antioxidative properties of Ocimum gratissimum alters Lead acetate induced oxidative damage in lymphoid tissues and hematological parameters of adult Wistar rats

Oyem, John Chukwuma; Chris-Ozoko, Lilian Ebite; Enaohwo, Mamerhi Taniyohwo; Otabor, Francisca Osamahemwem; Okudayo, Vera Anieze

doi:10.1016/j.toxrep.2021.01.003

Cited by 25 publications

(28 citation statements)

References 52 publications

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“…This is consistent with available information in literature which noted that onset of rise in peroxidation of lipids within tissues occurs in response to overwhelming rise in reactive oxygen and nitrogen species (ROS and RNS). This alarming increase is often in uenced by uncontrolled depletion of antioxidants serving as scavengers for ROS and RNS (Ramalingam, 2012;Oyem et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…The management of heavy metal poisoning ike lead and cadmium basically relies on use of chelating agents which in most cases are expensive with signi cant side effects (Twumasi et al, 2014). The use of natural products for treatments of various forms of poisoning proves to exert negligible side effects and is not nancially debilitating (Oyem et al, 2021;Orororo et al, 2018a-e;Okpoghono et al, 2018;Atagana and Asagba, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Palm oil extracts’ protected against cadmium chloride poisoning via inhibition of oxidative stress in rats”

Ichipi-Ifukor

Asagba

Nwose

et al. 2021

Preprint

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Background: The probable mechanism of an earlier reported capacity of palm oil extracts to confer protection against high dose cadmium poisoning in rats was reported in this study. Similar experimental design earlier reported by us was retained. Rats therefore were sacrificed at intervals of twelve; twenty four and forty eight hours post CdCl2 insult. Results: Oxidative stress and antioxidant status (malondialdehyde, superoxide dismutase, catalase and glutathione) were assessed in tissues (liver, kidney, heart, brain, muscle) and serum. Oxidative stress indicators showed a significantly (p<0.05) increased lipid peroxidation and alterations in antioxidant defence systems occasioned by drop in catalase and superoxide dismutase enzymes (serum, liver, heart, brain and kidneys) of the rats. Also observed were significant (p<0.05) reduction in the non-enzymatic antioxidant reduced glutathione over time. Pre-administration of rats with the crude palm oil and its extracts modulated cadmium mediated depletion of the antioxidant capacities of rats acutely exposed to cadmium and rising lipid peroxidation profile. Conclusions: Regulation of stress and antioxidant response was the underlying mechanism by which the extracts conferred protection against high dose cadmium insult thus suggesting its potential as a viable therapeutic target against its deleterious effects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Palm oil extracts’ protected against cadmium chloride poisoning via inhibition of oxidative stress in rats”

Ichipi-Ifukor

Asagba

Nwose

et al. 2021

Preprint

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“…(2017) 125 and 250 mg/kg/bw ethanol extract O. gratissimum Lead acetate induced Wistar rats Reduced MDA, increased GSH, SOD, and CAT. Attenuated anemia, thrombocytopenia, and leucocytosis Anti-oxidant and anti-anaemia activities Oyem et al. (2021) 200 and 400 mg/kg/day of aqueous leaf extract of O gratissimum Acetic acid-induced colitis in male Wistar rats Decreased the activities of MPO, SOD, NO and increased GSH levels in colitis rats Decreased diarrhea score and ulcer score to normal Anti-inflammatory and anti-oxidative properties.…”

Section: Pharmacological Activitiesmentioning

confidence: 97%

“…The antioxidant and anti-inflammatory properties of Ocimum gratissimum have been ascribed to its therapeutic benefits ( Olamilosoye et al., 2019 ; Oyem et al., 2021 ). Its leaf extracts have been shown to contain antioxidant vitamins such as alpha-tocopherol and ascorbic acid ( Olamilosoye et al., 2019 ).…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

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A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

Ugbogu

Emmanuel

Agi

et al. 2021

Heliyon

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In traditional medicine, Ocimum gratissimum (clove basil) is used in the treatment of various diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal and bacterial infections. The present study reviewed the phytochemicals, essential oils, and pharmacological activities of O. gratissimum . The bioactive compounds extracted from O. gratissimum include phytochemicals (oleanolic acid, caffeic acid, ellagic acid, epicatechin, sinapic acid, rosmarinic acid, chlorogenic acid, luteolin, apigenin, nepetoidin, xanthomicrol, nevadensin, salvigenin, gallic acid, catechin, quercetin, rutin, and kaempfero) and essential oils (camphene, β-caryophyllene, α- and β-pinene, α-humulene, sabinene, β-myrcene, limonene, 1,8-cineole, trans-β-ocimene, linalool, α- and δ-terpineol, eugenol, α-copaene, β-elemene, p-cymene, thymol, and carvacrol). Various in vivo and in vitro studies have shown that O. gratissimum and its bioactive constituents possess pharmacological properties such as antioxidant, anti-inflammatory, anticancer, hepatoprotective, antidiabetic, antihypertensive, antidiarrhoeal, and antimicrobial properties. This review demonstrated that O. gratissimum has a strong preventive and therapeutic effect against several diseases. The effectiveness of O. gratissimum to ameliorate various diseases may be attributed to its antimicrobial and antioxidant properties as well as its capacity to improve the antioxidant systems. However, despite the widespread pharmacological activities of O. gratissimum , further experiments in human clinical trial studies are needed to establish effective and safe doses for the treatment of various diseases.

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Prenatal double-hit with aluminium and cadmium mediate testicular atrophy and hypothalamic hypoplasia: the role of oxido-nitrergic stress and endocrine perturbations

Okhue,

Kadiri,

Ichipi-Ifukor

et al. 2024

Biometals

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Antioxidative properties of Ocimum gratissimum alters Lead acetate induced oxidative damage in lymphoid tissues and hematological parameters of adult Wistar rats

Cited by 25 publications

References 52 publications

Palm oil extracts’ protected against cadmium chloride poisoning via inhibition of oxidative stress in rats”

Palm oil extracts’ protected against cadmium chloride poisoning via inhibition of oxidative stress in rats”

A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

Prenatal double-hit with aluminium and cadmium mediate testicular atrophy and hypothalamic hypoplasia: the role of oxido-nitrergic stress and endocrine perturbations

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