Palm oil extracts’ protected against cadmium chloride poisoning via inhibition of oxidative stress in rats”

Abstract

Background: The probable mechanism of an earlier reported capacity of palm oil extracts to confer protection against high dose cadmium poisoning in rats was reported in this study. Similar experimental design earlier reported by us was retained. Rats therefore were sacrificed at intervals of twelve; twenty four and forty eight hours post CdCl2 insult. Results: Oxidative stress and antioxidant status (malondialdehyde, superoxide dismutase, catalase and glutathione) were assessed in tissues (liver, kidney, heart, brain, muscle) and serum. Oxidative stress indicators showed a significantly (p<0.05) increased lipid peroxidation and alterations in antioxidant defence systems occasioned by drop in catalase and superoxide dismutase enzymes (serum, liver, heart, brain and kidneys) of the rats. Also observed were significant (p<0.05) reduction in the non-enzymatic antioxidant reduced glutathione over time. Pre-administration of rats with the crude palm oil and its extracts modulated cadmium mediated depletion of the antioxidant capacities of rats acutely exposed to cadmium and rising lipid peroxidation profile. Conclusions: Regulation of stress and antioxidant response was the underlying mechanism by which the extracts conferred protection against high dose cadmium insult thus suggesting its potential as a viable therapeutic target against its deleterious effects.

Gallic acid abates cadmium chloride toxicity via alteration of neurotransmitters and modulation of inflammatory markers in Wistar rats

“…In addition to the binding of Cd to the sulfhydryl (-SH) group of the oxidative enzymes and inhibiting them, GSH depletion also renders the antioxidant enzymes inactive 36 . The current findings are consistent with those of Elkhadrag et al and Ichipi Ifukor et al 37 , 38 . Rutin, a well-known antioxidant, has been shown to have a similar effect on these antioxidant parameters 39 .…”

The effects of aqueous extract of ocimum gratissimum on the cerebellum of male wistar rats challenged by lead acetate

“…An increase in oxidative stress indicates a decrease in the antioxidant defence system. Since oxidative stress contributes meaningfully to the pathophysiology of diseases, substances that overwhelm oxidative stress might be therapeutically beneficial [19,37,41,42].…”

Red Palm Oil (RPO) May Enhance Chronic Inflammation Through Disturbance in Lipid Metabolism

“…We are aware that local processors often change approach based on economic reality especially when no one watches over them. By the way, the wear and tear of the rusty cooking irons used in the heating process coupled with the locally fabricated milling machines can adulterate final products by raising heavy metal contamination known to compromise the body’s antioxidant defense system (Ichipi-Ifukor1 et al, 2022).…”