Prenatal double-hit with aluminium and cadmium mediate testicular atrophy and hypothalamic hypoplasia: the role of oxido-nitrergic stress and endocrine perturbations

Okhue, Emmanuel; Kadiri, Helen Ejiro; Ichipi-Ifukor, Patrick Chukwuyenum; Ben-Azu, Benneth; Asagba, Samuel Ogheneovo; Achuba, Fidelis Ifeakachuku; Oyem, John Chukwuma

doi:10.1007/s10534-023-00563-0

Cited by 3 publications

References 112 publications

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Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

Ichipi-Ifukor,

Asagba,

Achuba

2024

Biol Trace Elem Res

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Most research has not been done on the possible relationship between pregnant women' cross-metal exposures and postpartum neuroendocrine functions. The purpose of this study was to look into how coexposure to aluminium chloride (AlCl3) and cadmium chloride (CdCl2) affected the neuroendocrine and neurometabolic changes in postpartum mice A total of 24 adult pregnant female mice were used for the study. Group 1 comprised pregnant mice (n = 6) treated with AlCl 3 (10mg/kg), group 2; CdCl 2 (1.5mg/kg), group 3 a combination of AlCl 3 (10 mg/kg) and CdCl 2 (1.5 mg/kg) and group 4 served as control. Oral treatment of animals was done daily from gestation day 7 to gestation day 20. Upon delivery and weaning on postnatal day 21 (PND 21), behavioural assessment was done on the postpartum mice and immediately followed by sacri ce for assessment of histological and neuroendocrine markers. Our ndings revealed that the brain-to-body weight ratio was affected and brain oxidative stress was elevated in mice exposed to AlCl 3 and CdCl 2 during pregnancy. Given the strong association between postpartum hyperactivity, social interaction index, brain catalase, and acetylcholinesterase activity, and the brain/body weight ratio, it is plausible that these effects have played a role in the adverse behavioural abnormalities observed in the postpartum maternal mice. Moreover, it noted that in certain situations, coexposures to the metals tended to have opposite effects to single metal exposures.

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Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

Ichipi-Ifukor,

Asagba,

Achuba

2024

Biol Trace Elem Res

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Hepatocellular degeneration in mice co-exposed to in-utero aluminium and cadmium: Implication of a disordered antioxidant and energy homeostatic response in the liver

Irerhievwie,

Ichipi-Ifukor,

Asagba

2024

Environmental Toxicology and Pharmacology

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Co-exposure to aluminium and cadmium mediates postpartum maternal variation in brain architecture and behaviour of mice; involvement of oxido-nitrergic and cholinergic mechanisms

Ichipi-Ifukor,

Asagba,

Achuba

2024

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Most research has not been done on the possible relationship between pregnant women' cross-metal exposures and postpartum neuroendocrine functions. The purpose of this study was to look into how co-exposure to aluminium chloride (AlCl3) and cadmium chloride (CdCl2) affected the neuroendocrine and neurometabolic changes in postpartum mice A total of 24 adult pregnant female mice were used for the study. Group 1 comprised pregnant mice (n = 6) treated with AlCl3 (10mg/kg), group 2; CdCl2 (1.5mg/kg), group 3 a combination of AlCl3 (10 mg/kg) and CdCl2 (1.5 mg/kg) and group 4 served as control. Oral treatment of animals was done daily from gestation day 7 to gestation day 20. Upon delivery and weaning on postnatal day 21 (PND 21), behavioural assessment was done on the postpartum mice and immediately followed by sacrifice for assessment of histological and neuroendocrine markers. Our findings revealed that the brain-to-body weight ratio was affected and brain oxidative stress was elevated in mice exposed to AlCl3 and CdCl2 during pregnancy. Given the strong association between postpartum hyperactivity, social interaction index, brain catalase, and acetylcholinesterase activity, and the brain/body weight ratio, it is plausible that these effects have played a role in the adverse behavioural abnormalities observed in the postpartum maternal mice. Moreover, it noted that in certain situations, co-exposures to the metals tended to have opposite effects to single metal exposures.

show abstract

Prenatal double-hit with aluminium and cadmium mediate testicular atrophy and hypothalamic hypoplasia: the role of oxido-nitrergic stress and endocrine perturbations

Cited by 3 publications

References 112 publications

Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

Hepatocellular degeneration in mice co-exposed to in-utero aluminium and cadmium: Implication of a disordered antioxidant and energy homeostatic response in the liver

Co-exposure to aluminium and cadmium mediates postpartum maternal variation in brain architecture and behaviour of mice; involvement of oxido-nitrergic and cholinergic mechanisms

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