Hepatocellular degeneration in mice co-exposed to in-utero aluminium and cadmium: Implication of a disordered antioxidant and energy homeostatic response in the liver

Irerhievwie, Omamuyovwi; Ichipi-Ifukor, Patrick Chukwuyenum; Asagba, Samuel Ogheneovo

doi:10.1016/j.etap.2024.104375

Environmental Toxicology and Pharmacology

2024

DOI: 10.1016/j.etap.2024.104375

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Hepatocellular degeneration in mice co-exposed to in-utero aluminium and cadmium: Implication of a disordered antioxidant and energy homeostatic response in the liver

Omamuyovwi Irerhievwie,

Patrick Chukwuyenum Ichipi-Ifukor,

Samuel Ogheneovo Asagba

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2024

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Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

Ichipi-Ifukor,

Asagba,

Achuba

2024

Biol Trace Elem Res

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Most research has not been done on the possible relationship between pregnant women' cross-metal exposures and postpartum neuroendocrine functions. The purpose of this study was to look into how coexposure to aluminium chloride (AlCl3) and cadmium chloride (CdCl2) affected the neuroendocrine and neurometabolic changes in postpartum mice A total of 24 adult pregnant female mice were used for the study. Group 1 comprised pregnant mice (n = 6) treated with AlCl 3 (10mg/kg), group 2; CdCl 2 (1.5mg/kg), group 3 a combination of AlCl 3 (10 mg/kg) and CdCl 2 (1.5 mg/kg) and group 4 served as control. Oral treatment of animals was done daily from gestation day 7 to gestation day 20. Upon delivery and weaning on postnatal day 21 (PND 21), behavioural assessment was done on the postpartum mice and immediately followed by sacri ce for assessment of histological and neuroendocrine markers. Our ndings revealed that the brain-to-body weight ratio was affected and brain oxidative stress was elevated in mice exposed to AlCl 3 and CdCl 2 during pregnancy. Given the strong association between postpartum hyperactivity, social interaction index, brain catalase, and acetylcholinesterase activity, and the brain/body weight ratio, it is plausible that these effects have played a role in the adverse behavioural abnormalities observed in the postpartum maternal mice. Moreover, it noted that in certain situations, coexposures to the metals tended to have opposite effects to single metal exposures.

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Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

Ichipi-Ifukor,

Asagba,

Achuba

2024

Biol Trace Elem Res

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Hepatocellular degeneration in mice co-exposed to in-utero aluminium and cadmium: Implication of a disordered antioxidant and energy homeostatic response in the liver

Cited by 1 publication

References 64 publications

Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

Co-exposure to Aluminium and Cadmium Mediates Postpartum Maternal Variation in Brain Architecture and Behaviour of Mice; Involvement of Oxido-nitrergic and Cholinergic Mechanisms

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