Antioxidative Potential of Spices in Experimentally Induced Type-II Diabetes in Rats

Sheikh, Tanveer; Joshi, D.V.; Patel, Bhagyabhumi; Ranjan, Rajeev

doi:10.20546/ijcmas.2019.803.144

Cited by 2 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, ginger possesses antioxidant properties and help to stabilize the RBC membrane by binding to RBC membrane-component proteins and carbohydrates, thereby preventing the breakdown of the RBC membrane and antagonizing the anemic impact of STZ. On other hand, the hematological findings in treated animals with aqueous extract of N. sativa, garlic, fenugreek individual and its combination at different doses in STZ-NAinduced diabetic rats revealed non-significant change in erythrocyte parameters [67].…”

Section: Discussionmentioning

confidence: 88%

Effect of Zingiber officinale and Nigella sativa on Streptozotocin-Diabetic Rats with Reference to Biochemical and Hematological Studies

Ibrahim

Hashem

Mohamed

et al. 2020

Zagazig Veterinary Journal

View full text Add to dashboard Cite

This study was aimed to assess the potential ameliorative effect of the ethanolic extract of Zingiber officinale (Z. officinale; ginger) and Nigella sativa (N. sativa; black seed) on streptozotocin (STZ)-diabetic rats. Fifty albino rats of Wistar strain were randomly divided into five equal groups. Group 1 received saline orally (a control group). Groups 2-5 were experimentally exposed to diabetes via intraperitoneal (i.p.) injection of STZ (55 mg/kg BW.). The 2 nd group was left without treatment as diabetic non-treated control, while the 3 rd to 5 th groups were orally treated with metformin (100mg/kg BW), ethanolic extract of ginger (200mg/kg BW.) and N. sativa (300mg/kg BW.), respectively for 21 consecutive days. Blood and pancreatic tissue samples were collected at the end of the experiment for biochemical analysis. The results revealed that blood glucose, fructosamine and insulin levels were improved following treatment by metformin (99.00±4.76, 198.69±5.25 and 29.82±2.35, respectively), and ethanol extract of ginger (105.20±4.87, 317.48±17.79 and13.64±0.72, respectively). Meanwhile, N. sativa extract produced insignificant decrease in glucose level (201.60±14.91) and significant improvement in serum fructosamine and insulin levels (273.20±6.39 and 21.65±1.78) if matched with the diabetic control group on the 3 rd week of the experiment. Treating of diabetic rats with metformin and N. sativa extract elicited a significant increase in blood RBCs count (6.21±0.170 and 5.63±0.135), Hb concentration (12.96±0.229 and 12.00±0.141), PCV% (46.40±1.077 and 74.72±1.085), tissue catalase (0.32 ±0.012 and 0.25±0 .009) and superoxide dismutase activities (19.44±2.16 and 12.77±0.914), respectively when compared with the diabetic group. However, administration with ginger extract produced variable changes in the erythrogram and leukogram. This study provided that Z. officinale and N. sativa extracts have significant effects on some biochemical and hematological assays, as compared with metformin known as standard antidiabetic drug. Consequently, the herbal extracts under current inquiry could have a role in alleviating the risk of some chronic complications of diabetes.

show abstract

Section: Discussionmentioning

confidence: 88%

Effect of Zingiber officinale and Nigella sativa on Streptozotocin-Diabetic Rats with Reference to Biochemical and Hematological Studies

Ibrahim

Hashem

Mohamed

et al. 2020

Zagazig Veterinary Journal

View full text Add to dashboard Cite

show abstract

Anti-diabetic Potential of some Spices Commonly used in Diet with other Pharmacological Activities: A Review

Kundu

2022

CTM

View full text Add to dashboard Cite

Background:: Diabetes mellitus is a chronic metabolic disorder, the prevalence of which is rising alarmingly throughout the world and imposes a serious impact on the health of population as well as national economies. Effective management and primary prevention are essential to decrease the burden of diabetes faced by all nations. Although different therapies are available for diabetes, no known therapy can completely cure the disease and many of them have a number of side effects with other limitations like long term treatment, expensiveness and less availability. Hence, the present review has given an emphasis on common dietary materials to find out a readily available source of antidiabetic agents. Objective: The purpose of this work is to explore the antidiabetic properties of certain spices most frequently used in Bangladeshi kitchen and reported for the use in traditional treatment of diabetes and/or investigated scientifically for antidiabetic activity. Methods: Two electronic databases namely Pub Med and Google Scholar were used for conducting comprehensive search to collect information and data. Results: In this review, a total of 10 spices have been compiled with brief description about their origin, part used, chemical constituents, mechanism of action, methods of experiment, model animals and reported beneficial effects in diabetes with other pharmacological activities. Conclusion: The observed results of this study indicate the possibility of developing a therapeutic strategy called alternative and complementary medicine for the management of diabetes. The results also provide a starting point for researchers working with bioactive dietary plants that have antidiabetic potential.

show abstract

Antioxidative Potential of Spices in Experimentally Induced Type-II Diabetes in Rats

Cited by 2 publications

References 23 publications

Effect of Zingiber officinale and Nigella sativa on Streptozotocin-Diabetic Rats with Reference to Biochemical and Hematological Studies

Effect of Zingiber officinale and Nigella sativa on Streptozotocin-Diabetic Rats with Reference to Biochemical and Hematological Studies

Anti-diabetic Potential of some Spices Commonly used in Diet with other Pharmacological Activities: A Review

Contact Info

Product

Resources

About