Antioxidant Effect of Chlorella vulgaris on Physiological Response of Rat Induced by Carbon Tetrachloride

Hernayanti, Hernayanti; Simanjuntak, Sorta Basar Ida

doi:10.15294/biosaintifika.v11i1.16393

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…Many plants that has long been used as an alternative medicine in treating infertility problem are Eurycoma longifolia Jack. (Pratomo, 2012), Cordyline fruticosa (Amudha & Rani, 2016), and Chlorella vulgaris (Hernayanti & Simanjuntak, 2019). Plant ability to resolve infertility is assumed to be caused by the bioactive compound compositions which can influence folliculogenesis and steroidogenesis.…”

Section: Introductionmentioning

confidence: 99%

Characteristics and Antioxidant Activity of Kebar Grass (Biophytum petersianum) Extract

Aminudin¹,

Andarwulan²,

Palupi³

et al. 2020

J Bio Bio Edu

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Kebar grass (Biophytum petersianum Klotzsch.) has long been known by the locals of West Papua as medicinal plant that improves fertility. The objectives of this research were to identify and determine the antioxidant activity of kebar grass crude extract through conventional method and to analyze for its antioxidant activity. Extraction method used was conventional method, performed by mixing dry kebar grass with water and boiled until the volume shrunk to 1/3 of initial volume. Analized parameters were crude extract yield, qualitative phytochemical, total phenol and antioxidant activity. Research result showed extract crude yield value of 18.32±0.01%. Qualitative phytochemical contents were dominated by flavonoid, tannin, and saponin. Total phenolic content (TPC) of crude extract was 147±1.24 mgGAE/gdw (0.688±0.01 mgGAE/gfw). Crude extract antioxidant parameter was measured as the value of inhibition, AEAC, TEAC, and IC50 where each value respectively was as followed 42.0±0.047%, 69.93±2.19 mgAE/gdw (8.30±0.26 mgAE/gfw), 65.70±1.54 mgTE/gdw (7.80±0.18 mgTE/gfw) and 0.129±0.003 mgdw (257.75±4.90 mg/L). The contribution of kebar grass TPC content to antioxidant activity is 47.38% (equal to ascorbic acid) and 44.51% (equal to trolox) which means that almost half of kebar grass crude extract’s phenolic compound act as antioxidant. The results of this research can show that the kebar grass has potential as a source of multiple antioxidants, which acts as an analogue of vitamin C and vitamin E. The antioxidant activity of the kebar grass extract can be the scientific basis for the use of kebar grass as a medicinal plant for infertility problems (curative) and as a functional food ingredient for antioxidant sources that prevent a decrease in reproductive performance (preventive).

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Section: Introductionmentioning

confidence: 99%

Characteristics and Antioxidant Activity of Kebar Grass (Biophytum petersianum) Extract

Aminudin¹,

Andarwulan²,

Palupi³

et al. 2020

J Bio Bio Edu

View full text Add to dashboard Cite

show abstract

“…Many of beneficial effects of CV revealed through animal models. In study on male rats using of 5 mg/100 g body weight of CV, presented a protectant effect on hepatic toxicity (Hernayanti and Simanjuntak, 2019). CV accelerated curative effect has been demonstrated via topical application of CV on wound in this study [23].…”

Section: Introductionmentioning

confidence: 56%

“…On the other hands, antioxidant marker GPx enzyme exhibited near control level, whereas levels of MDA were inhibited when a male rats treated with CV for 30 days. The elevation may be attributed to existence of Glutathione content as a component of CV which act to reduce ROS generation via GPx utilization of Glutathione as electron donor [56].…”

Section: Groupsmentioning

confidence: 99%

Attenuating effect of Chlorella Vulgaris against acrylamide intoxication on thyroid gland

Alabbadi

Ayaz

Elhalwagy

2022

ijhs

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Oral administration of Acrylamide in our food produces adverse health effects through different vital systems. This study examined the effect of simultaneous oral supplementation of unicellular algae Chlorella vulgaris (CV) on thyroid gland disruption induced by intoxication with Acrylamide (ACR). Healthy male rats (n=60) distributed in six groups: -ve control, +ve control (CV 300 mg/kg), low dose Acrylamide (LACR, 5 mg/kg), high dose Acrylamide (HACR, 50 mg/kg), pre-administration of Chlorella Vulgaris with Acrylamide CV+ LACR (5mg/kg), and with Acrylamide CV+HACR (50 mg/kg). All groups received treatments orally for 30 days. ACR treated groups (LACR, HACR) demonstrated a significant elevation in oxidative stress biomarkers Malondialdehyde (MDA), 4-Hydroxynonenal (4-HNE), Nitric Oxide (NO) and pro-inflammatory cytokines C-reactive protein (CRP), Tumor Necrosis Factor alpha (TNF-α), Interleukin 6 (IL-6) and Interleukin 1 beta (IL-1β). In relation to antioxidant biomarkers Glutathione (GSH) and Glutathione peroxidase (GPx), GSH recorded significant reduction while GPx indicated significant elevation as compared to control and +ve control group at (p<0.05). Thyroid gland biomarkers showed reduction in Thyroid-Stimulating hormone (TSH) in ACR groups whereas Thyroxine (T4) and Triiodothyronine (T3) presented a significant elevation.

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“…C. pyrenoidosa, a single-celled microalga that grows in freshwater, is widely used in Japan and is consumed as a food supplement known to have beneficial effects on immune function. Chlorella is rich in antioxidants (Hernayanti & Simanjuntak, 2019;Yu et al, 2019;Wan et al, 2021). It was reported that Chlorella extract has an anticancer effect on hepatocellular cancer cell line (HepG2) and Ehrlich ascites carcinoma cell (Adzahar et al, 2021).…”

Section: What Is Chlorella?mentioning

confidence: 99%

“…Due to these properties, it has been reported that it has a protective effect, especially in tissues exposed to intense oxygen and, therefore, oxidative stress. We can add hepatoprotective to this protective effect (Hernayanti & Simanjuntak, 2019;Zafar et al, 2021;Zhang et al, 2019c;Capek et al, 2020). C.…”

Section: What Is Chlorella?mentioning

confidence: 99%

A Functional Food: Anzer Honey

Çil¹

2023

Versatile Approaches to Engineering and Applied Sciences: Materials and Methods

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Honey; It is a sweet product created by bees by collecting plant nectar and changing its content in their bodies, then taking its final form with maturation in the honeycomb. Apis mellifera, one of the insects of the genus Apis, known as honey bees, is responsible for producing most of the honey consumed worldwide. Since the bees use various plant nectars as raw materials, the variety of honey is very high, and technically, no honey is precisely the same as the other. It can be said that the most important reason for this is that honey is obtained from different plants by being exposed to different climatic conditions. Honey is a significant functional food that people have consumed since the hunter-gatherer periods due to its nutritional content and positive effects on health. Research has shown that beekeeping has been practiced in Anatolia since the Hittites. Flower honey produced in Anzer Plateau is one of the market's most popular and expensive honey. In this study, studies on Anzer honey, the first product with a geographical indication in Rize, where important honey producers are located in Turkey, the second largest honey producer in the world, will be compiled.

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Antioxidant Effect of Chlorella vulgaris on Physiological Response of Rat Induced by Carbon Tetrachloride

Cited by 8 publications

References 21 publications

Characteristics and Antioxidant Activity of Kebar Grass (Biophytum petersianum) Extract

Characteristics and Antioxidant Activity of Kebar Grass (Biophytum petersianum) Extract

Attenuating effect of Chlorella Vulgaris against acrylamide intoxication on thyroid gland

A Functional Food: Anzer Honey

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