Oral administration of Acrylamide in our food produces adverse health effects through different vital systems. This study examined the effect of simultaneous oral supplementation of unicellular algae Chlorella vulgaris (CV)   on thyroid gland disruption induced by intoxication with Acrylamide (ACR). Healthy male rats (n=60) distributed in six groups: -ve control, +ve control (CV 300 mg/kg), low dose Acrylamide (LACR, 5 mg/kg), high dose Acrylamide (HACR, 50 mg/kg), pre-administration of Chlorella Vulgaris with Acrylamide CV+ LACR (5mg/kg), and with Acrylamide CV+HACR (50 mg/kg). All groups received treatments orally for 30 days. ACR treated groups (LACR, HACR) demonstrated a significant elevation in oxidative stress biomarkers Malondialdehyde (MDA), 4-Hydroxynonenal (4-HNE), Nitric Oxide (NO) and pro-inflammatory cytokines C-reactive protein (CRP), Tumor Necrosis Factor alpha (TNF-α), Interleukin 6 (IL-6) and Interleukin 1 beta (IL-1β). In relation to antioxidant biomarkers Glutathione (GSH) and Glutathione peroxidase (GPx), GSH recorded significant reduction while GPx indicated significant elevation as compared to control and +ve control group at (p<0.05). Thyroid gland biomarkers showed   reduction in Thyroid-Stimulating hormone (TSH) in ACR groups whereas Thyroxine (T4) and Triiodothyronine (T3) presented a significant elevation.