Antimicrobial and antiseptic strategies in wound management

Abstract

Wounds, especially chronic wounds, represent a global problem costing millions of dollars per year in developed countries and are characterised by microbial complica-

Cetylpyridinium chloride and miramistin as antiseptic substances in chronic wound management – prospects and limitations

“…Two recent reviews also concluded that 'advanced wound dressings' had no significant advantage over conventional wound contact materials in diabetic foot ulcers (Dumville et al, 2013) and venous leg ulcers (O'Meara & Martyn-St James, 2013) in terms of overall healing rates. Still, in cases of critically colonized or infected wounds, as well as biofilm formation, wound cleansing and the reduction of bacterial wound burden with antiseptics and antimicrobial wound dressings is of great importance in wound management (Daeschlein, 2013). Hence, there is still a need for the detection of new effective antiseptics as well as the development of modern wound dressings for improving chronic wound treatment in order to increase patients' health-related quality of life.…”

An Asian Perspective on Povidone Iodine in Wound Healing

“…The properties of an ideal antimicrobial agent have been described in detail in several publications [1,11,[13][14][15][16] .The efficacy profile of an ideal antimicrobial agent for wound care should include a broad antimicrobial effect (antibacterial [Gram-positive and Gram-negative bacteria], antimycotic, and antiviral), good local penetration, stability in the presence of body fluids and wound exudates, and a low potential for acquired resistance. From a safety viewpoint, an ideal antiseptic should also have good local and systemic tolerability and low systemic absorption, be nonsensitizing/hypoallergenic, and cause no delay in the wound healing process [11,13,14,16] .…”

“…From a safety viewpoint, an ideal antiseptic should also have good local and systemic tolerability and low systemic absorption, be nonsensitizing/hypoallergenic, and cause no delay in the wound healing process [11,13,14,16] .…”

Aplicação tópica de Bexident Gengivas® vs Bexident Post® – Efeitos na cicatrização pós extração. Estudo piloto

“…Esta associação permite reduzir a formação de placa bacteriana e melhorar a cicatrização através do efeito positivo na proliferação e regeneração celular. 5 Estão disponíveis no mercado diferentes antissépticos, mas a Clorohexidina (CHX) é desde há muito tempo o gold standard, devido ao seu efeito anti -bacteriano e anti -placa. 6,7 Apesar da sua eficácia, a CHX apresenta alguns efeitos secundários (coloração da mucosa e alterações de paladar).…”