Antiinflammatory, analgesic and antiperoxidative efficacy of Barleria lupulina Lindl. extract

Abstract

A study was undertaken to investigate the antiinflammatory efficacy of methanol extract of aerial parts of Barleria lupulina Lindl. [MEBL] (Family: Acanthaceae) in acute and sub-acute inflammation models of albino rats. The MEBL in all the tested dose levels exhibited significant inhibition of carrageenin and serotonin induced paw oedema volumes when compared with the untreated (control) group. The MEBL also exerted a significant reduction in granuloma weight in the cotton pellet induced granuloma model. These potentials were comparable to that of the standard drug (indomethacin). The plant extract was also tested for its analgesic, ulcerogenic and antiperoxidative potential. The extract also demonstrated protection against CCl(4) induced lipid peroxidation and acetic acid induced writhing. Acute administration of MEBL (300 mg/kg) did not produce any gastric lesion in rats.

Anti-inflammatory activity of the essential oils of Cymbopogon validus (Stapf) Stapf ex Burtt Davy from Eastern Cape, South Africa

“…An initial phase during the first 1.5 h is caused by the release of histamine and serotonin [20]. The second phase involves the release of bradykinin from 1.5 h to 2.5 h, whilst the third phase involves the release of prostaglandins and that occurs from 2.5 h to 6.0 h after albumin injection [21]. The current study lasted for only 120 min due to rapid resolution of inflammation.…”

Phytochemical Screening and Evaluation of Anti-Inflammatory Activity of Aerial Part Extracts of Plantago Major L.

“…Carrageenan is phlogistic agent which induced edema develops by mediators in two phases, so inflammation produced by carrageenan has a biphasic effect. The first phase is due to release of mediators such as histamine and serotonin occurs within 0-2 hrs [35] and the second accelerating phase edema is attributed to bradykinins and PG release (>4 th hr) [36]. The results of the present study showed that methanol extract of P. major significantly inhibited the formation of the rat paw edema in the early and late phases.…”

Anti-Inflammatory Activity of <i>Chrozophora rottleri</i> Extracts on Carrageenan-Induced Rat Paw Edema

“…The local injection of carrageenan-induced inflammatory process in the rat involves three phases through sequential release of several mediators. An initial phase, during the first 1.5 h, is caused by the release of histamine and serotonin [22], a second phase is mediated by bradykinin from 1.5 to 2.5 h and finally, a third phase, the mediator of which is suspected to be prostaglandins occurs from 2.5 to 6 h after carrageenan injection [23]. This third phase appears to be the most interesting phase in terms of inflammatory processes.…”