Anti-inflammatory activity of the essential oils of Cymbopogon validus (Stapf) Stapf ex Burtt Davy from Eastern Cape, South Africa

Rungqu, Pamela; Oyedeji, Opeoluwa O.; Nkeh-Chungag, Benedicta N.; Songca, Sandile P.; Oluwafemi, Oluwatobi S.; Oyedeji, Adebola O.

doi:10.1016/j.apjtm.2016.03.031

Cited by 19 publications

(10 citation statements)

References 18 publications

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“…These results suggest that the anti-inflammatory activity may be brought about by the biosynthesis inhibition of inflammation mediators such as prostaglandin, histamine or serotonin. Similar results were obtained by Perez et al, (2005) and Rungqu et al (2016). The antinociceptive properties of the major constituent of the essential oil (pulegone) were studied in chemical and thermal models of nociception.…”

Section: Discussionsupporting

confidence: 81%

Anti-Inflammatory Effects and Safety of Extracts and Essential Oil From Clinopodium Gilliesii (Muña Muña)

Reynoso

Coca

Brodkiewicz

et al. 2018

Int. J. Pharm. Sci. Drug Res.

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The chemical machinery of vegetables offers a great diversity of biological properties and plays a fundamental role in the field of pharmacology. The search for new drugs with fewer adverse effects represents a challenge for researchers. The objective of the present work was to carry out to investigate the medicinal properties and safety of extracts and essential oil from aerial parts of Clinopodium gilliesii (muña muña) and evaluate their antioxidant and anti-inflammatory activities in vivo. The extractions were carried out serially, using 96º alcohol (EE) and boiled distilled water (AE). The essential oil (EO) was obtained by steam dragging. The AE in vivo anti-inflammatory activity was determined by carrageenan induced plantar edema (acute inflammation) and granuloma formation by cotton disc (chronic inflammation) at oral doses of 250 and 500 mg/kg while that of the EO was established topically at doses of 50, 100μl/kg. In-vitro antioxidant activity was evaluated by DPPH depuration and inhibition of lipid peroxidation (β-carotene-linoleic acid method). Chemical study of the extracts was carried out by means of phytochemical screening and the essential oil was analyzed by GC-MS chromatography. The safety was evaluated with test of acute toxicity (48 h) and acute dermal toxicity (14 days). The results revealed that EE and EO had a significant acute and chronic anti-inflammatory activity, compared with positive patterns. EE (500 mg/kg), EO (100μl/kg), ibuprofen (100 mg/kg) and meprednisone (5 mg/kg) significantly reduced the weight of the exudate and cotton disc granuloma (24.17, 35.30, 45.56 and 57.17% respectively). The alcoholic and aqueous extracts presented important antioxidant activities with values higher than 90% (from 400μg/ml) in both methods and similar to the positive patterns (BHT and quercetin). The chromatographic profile of volatile oil compounds showed a great richness in terpene substances, pulegone, menthone and neomenthol, being its major constituents. The hydroalcoholic extracts revealed the presence of reducing compounds, polysaccharides, tannins, triterpenes, sterols and coumarins as major phytoconstituents. In the acute toxicity study, a single dose of 4000 and 8000 mg/kg b.w., produced no mortality and no clinical signs of disease were observed after 48 h. The essential oil at a single dose of 2000 and 5000 mg/kg of body weight did not produce treatment-related signs of toxicity or mortality in all rats tested during the 14 day observation period. These findings are encouraging to continue studies for the validation of popular use and development of a phytopharmaceutical with medicinal utility.

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Section: Discussionsupporting

confidence: 81%

Anti-Inflammatory Effects and Safety of Extracts and Essential Oil From Clinopodium Gilliesii (Muña Muña)

Reynoso

Coca

Brodkiewicz

et al. 2018

Int. J. Pharm. Sci. Drug Res.

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“…EOs are natural, complex, and multicomponent systems composed mainly of terpenes, terpenoids, aromatic, and aliphatic constituents (Edris, ; Boukaew, Prasertsan, & Sattayasamitsathit, ; Zahrana, Abou‐Talebb, & Abdelgaleil, ). Previous studies have demonstrated that plant extracts and essential oils or their active constituents has a number of biological activities including antioxidant (Tohidi, Rahimmalek, & Arzani, ), antimicrobial (Ambrosio et al, ), antiviral (Gavanji, Sayedipour, Larki, & Bakhtari, ), antifungal (Boukaew et al, ), anti‐inflammatory (Rungqu et al, ), and antitumor activity (Nikolić et al, ). So, incorporation of EOs into film formulation may enhance the antimicrobial, antioxidant, and physicomechanical properties of the films.…”

Section: Introductionmentioning

confidence: 99%

Morphological, physico-mechanical, and antimicrobial properties of sodium alginate-montmorillonite nanocomposite films incorporated with marjoram essential oil

Alboofetileh

Rezaei

Hosseini

2018

J Food Process Preserv

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Combined effect of montmorillonite nanoclay (MMT) (3%w/w) and Origanum majorana essential oil (MO) (0.5, 1.0, and 1.5%v/v) on microstructural (SEM, TEM, and XRD), water sensitivity, barrier, mechanical, thermal, and antibacterial properties of sodium alginate (SA) was studied. Results showed that, addition of both MMT and MO reduced water solubility of SA film up to 47% while MO increased water vapor permeability of SA/MMT films. MO improved surface hydrophobicity of SA/MMT film but tensile strength tend to decrease when both MMT and MO (≥ 1%v/v) were added into film formulation. The nanocomposite film inhibited the growth of Escherichia coli, Listeria monocytogenes, Bacillus cereus, and Staphylococcus aureus at 1.5% MO concentration confirming the functionality of the films. Finally, combined application of MMT and MO could provide a tool for developing an active SA film with minimized side effects caused by the hydrophobic nature of the essential oil. Practical application Huge amounts of synthetic packaging materials used during last decades has caused serious environmental problems resulting great efforts by both governments and researchers for finding innovative alternatives for the conventional packaging materials. Biodegradable packaging materials has been introduced as a promising solution for the problem. Biodegradable packaging materials like biopolymer based films can be produced from proteins, carbohydrate and lipids and can be replaced or complement traditional packaging systems. Up to now, biopolymer‐based packaging materials have been partially successfully used to prolong the shelf life of food products. However, there are still new developments in various fields and from various perspectives worth reporting. This study developed and characterized a biodegradable and antimicrobial nanocomposite films by incorporating MMT nanoparticles and marjoram essential oil in sodium alginate matrix.

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“…C. jwarancusa was found to have a flukicidal activity which used as alternative sources of treatment for trematodes infection (Shafiq et al 2015). C. validus (Stapf) Stapf ex Burtt Davy had potential as an anti-inflammatory (Rungqu et al 2016), and C. winterianus was found exhibiting potential as a mosquito repellent, bioinsecticide (Deletre et al 2015;Sajo et al 2015;Silva et al 2018), and as an orofacial antinociceptive (Santos et al 2015).…”

Section: Introductionmentioning

confidence: 99%

The phytochemistry of Cymbopogon winterianus essential oil from Lombok Island, Indonesia and its antifungal activity against phytopathogenic fungi

et al. 2018

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Andila PS, Hendra IPA, Wardani PK, Tirta IG, Sutomo, Fardenan D. 2018. The phytochemistry of Cymbopogon winterianus essential oil from Lombok Island, Indonesia and its antifungal activity against phytopathogenic fungi. Nusantara Bioscience 10: 232-239. Cymbopogon winterianus Jowitt ex Bor [Sereh Wangi] is a plant producing essential oil that has been extensively used in perfumery, mosquito repellent, medicinal, and cosmetic industry. In Indonesia, the accession of C. winterianus plant had been collected from natural forest in Sembalun, Lombok, West Nusa Tenggara (NTB) Province. However, the phytochemical properties and its biological potential of this accession have never been reported. The aim of this study was to determine the phytochemical content of essential oil of C. winterianus from Lombok and to explore its potential as a bioantifungal against several phytopathogen fungi. The essential oils were extracted from fresh stem and leaf of C. winterianus by hydrodistillation. The chemical composition of them was determined by chromatography-mass spectrometry (GC-MS). A total of 26 and 20 compounds were obtained from the stem and leaf oil with the dominant compounds of essential oil in stem were Torreyol (17.89%), Oxirane, octyl- (15.84%), (-)-Isopulegol (14.44%), Isopulegol 2 (12.18%), and Geranyl Acetate (5.89%) while in leaf were (-)-Isopulegol (22.69%), Oxirane, octyl- (16.64%), Cyclohexanol, 5-methyl-2-(1-methylethenyl)- (14.21%), "KW3 AUS Epiglobulol” (9.47%), and Cyclohexene, 1-methyl-4-(1-methylethenyl)- (7.14%). The presence of these contents as dominant chemical compounds in S. winterianus was reported for the first time. The highest content of oils was identified as monoterpene (38.01% and 45.78% in stem and leaf oil) and sesquiterpene ( 27.67% and 17.78 % in stem and Leaf oil). The biological study showed that leaf essential of C. winterianus expressed positive antifungal activity against Fusarium solani, Aspergillus niger, dan Cladosporium sp.

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Anti-inflammatory activity of the essential oils of Cymbopogon validus (Stapf) Stapf ex Burtt Davy from Eastern Cape, South Africa

Abstract: The findings of this study show that the essential oil extracted from C. validus fresh or dry leaves and flowers have anti-inflammatory properties; that might be associated with the major components and the minor components found in the essential oils.

Cited by 19 publications

References 18 publications

Anti-Inflammatory Effects and Safety of Extracts and Essential Oil From Clinopodium Gilliesii (Muña Muña)

Anti-Inflammatory Effects and Safety of Extracts and Essential Oil From Clinopodium Gilliesii (Muña Muña)

Morphological, physico-mechanical, and antimicrobial properties of sodium alginate-montmorillonite nanocomposite films incorporated with marjoram essential oil

The phytochemistry of Cymbopogon winterianus essential oil from Lombok Island, Indonesia and its antifungal activity against phytopathogenic fungi

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