Phytochemical Screening and Evaluation of Anti-Inflammatory Activity of Aerial Part Extracts of Plantago Major L.

Abstract

Objective: This study aims to perform phytochemical screening and investigate anti-inflammatory activity of extract from aerial part of the plant Plantago major L.Methods: Preliminary phytochemical screening of plant extract was carried out using standard qualitative procedures and anti-inflammatory activity was evaluated using carrageenan-induced paw edema model in male Wistar albino rats using plethysmometer. Diclofenac sodium (10 mg/kg, b.w.) was used as standard drug.Results: Preliminary phytochemical screening of the different extracts revealed that they were rich in secondary metabolite compounds such as carbohydrates, tannins, steroids, flavonoids, terpenoids, glycosides, fats and oils, alkaloids, phenolic compounds, and iridoid glycosides. The antiinflammatory activity was evaluated using carrageenan-induced paw edema models in Wistar albino rats. The anti-inflammatory activity of methanolic extract (ME) was found to be dose dependent in carrageenan-induced paw edema model. The ME has shown significant (p<0.05) inhibition of paw edema, 61.11% and 55.55% on 4 th hr at the doses of 900 and 600 mg/kg, respectively. Conclusion:The results of the present study demonstrate that ME of the aerial parts of the plant possess significant (p<0.05) anti-inflammatory potential.

Microscopic, Physicochemical and Phytochemical Analysis of Gardenia Jasminoides (Ellis)

“…These phytochemicals present in the extracts may facilitate the extracts to act as wound healing substance [15]. Phytochemicals are plant chemicals known to play an important role in the biological activity of medicinal plants [19].…”

Plantago media L.—Explored and Potential Applications of an Underutilized Plant

“…The anti-inflammatory potential of P. media [ 43 ] was supported by the application of P. major and P. lanceolata extracts as anti-inflammatory agents (either in vitro, in carrageenan-induced paw edema model, by determining the expression of the proinflammatory enzyme, cyclooxygenase, or on oral epithelial cells), an effect attributed to the presence of phenylethanoid compounds (in particular, verbascoside) [ 70 , 71 , 72 , 73 ].…”

Antidiabetic, Anti-Inflammatory, Antibacterial, Anti-Helminthic, Antioxidant and Nutritional Potential of Musa Paradisiaca

“…Inflammation could be classified as acute and chronic; while acute inflammation is the initial stage of inflammation that persists for a short time, chronic inflammation, on the other hand, persists for longer period and depending on the intensity of the inflammation, mediators that are elicited in the affected area could reach the circulation and cause fever [20,21]. Inflammation is a complex pathophysiological process, mediated by different signaling molecules [15,32]. To investigate the anti-inflammatory activity of M. paradisiaca, Ibegbu et al [13] collected the root of plantain plant from plantain plantation in Lagos State, Nigeria.…”

“…Analysis of ripe and unripe extracts of M. paradisiaca shows that it contains carbohydrate, protein, fat, fiber, ash, and moisture. It is also found to provide calcium, potassium, manganese, sodium, zinc, phosphorus, nitrogen, iron, and copper [12,15].…”

“…The medicinal properties are believed to be associated with its constituents such as polysaccharides, lipids, caffeic acid derivatives, flavonoids, iridoid glycosides, terpenoids, alkaloids, and specific organic acids. Its leaves and seeds have been reported to possess wound healing property, anti-inflammatory, antioxidant, and immune-promoting activities [15,20,21].…”