Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids

Unnikrishnan, M.K.; Veerapur, V. P.; Nayak, Yogendra; Mudgal, Piya Paul; Mathew, Geetha

doi:10.1016/b978-0-12-398456-2.00013-x

Cited by 31 publications

(28 citation statements)

References 182 publications

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“…El efecto hipolipemiante se debería a la presencia de flavonoides, los cuales ejercen su efecto por diversos mecanismos: eliminando radicales libres, reponiendo el suministro limitado de antioxidantes tales como el alfa tocoferol y quelación divalente de metales de transición prooxidante tales como el hierro y cobre, por lo tanto, previene la formación de radicales libres. Asimismo, la presencia de quercetina y glicósidos de quercetina han mostrado que protegen contra la oxidación de las lipoproteínas de baja densidad (21) .…”

Section: Discussionunclassified

Efecto del extracto etanólico de las hojas de Annona muricata L (guanabana) sobre Síndrome metabólico inducido en ratas

Palomino-Flores¹,

Arroyo-Acevedo²

2017

Rev. per. med. integr.

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Objetivo. Evaluar el efecto del extracto etanólico de hojas de guanábana (EEA) administrado en ratas con síndrome metabólico experimental. Materiales y Métodos: Estudio Experimental. 90 ratas machos de 2 meses, cepa Holtzmann de 175±25g de peso fueron divididos en nueve grupos: I) normal (Suero salino fisiológico-SSF-2mL/kg); II) EEA 200mg/kg; III) 200mg/kg de colesterol y 100mg/kg de fructosa (CF) para inducción de síndrome metabólico (SM); IV-VI) CF + EEA 50, 100 y 200mg/kg respectivamente; VII) CF + atorvastatina 20mg/kg; VIII) CF + enalapril 20mg/kg; IX) CF + enalapril 20mg/kg + atorvastatina 20mg/kg. corporal. Estos grupos fueron intervenidos por 90 días, donde se midieron: peso corporal (g), niveles de glicemia (mg/dL), hemoglobina glicosilada (HbA1c), presión arterial (mmHg) y perfil lipídico (Colesterol total, triglicéridos, HDL-c y LDL-c en mg/dL). Resultados. Se encontraron diferencias significativas en comparación, en los valores de glicemia (-23.9 mg/ml; IC95%: -36.7 a -11.0), HbA1c (-0.8%; IC95%: -1.2 a -0.4) y Triglicéridos (-68.1; IC95% -96.0 a -40.1) en la dosis de EEAM 200mg/kg en comparación con el grupo III. La dosis de 100mg/kg logró presiones arteriales: sistólica (-6.8 mmHg; IC95%: -17.5 a 3.9, p=0.397), diastólica (-3.9 mmHg; IC95%: -14.0 a 6.2, p=0.861) y media (-9.9 mmHg; IC95%: -31.1 a 11.3, p=0.720); parecidas al grupo I. Asimismo, esta dosis logró diferencias en colesterol total (-57.6 mg/dl; IC 95% -75.7 a -39.4) y LDL-c (-56.5 mg/dl; IC 95% -75.7 a -37.3) en comparación con el grupo III. Conclusiones: El extracto etanólico de las hojas de Annona muricata L. (guanábana) a dosis de 200 mg/Kg mostró un mejor efecto ante la inducción de síndrome metabólico experimental.

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Section: Discussionunclassified

Efecto del extracto etanólico de las hojas de Annona muricata L (guanabana) sobre Síndrome metabólico inducido en ratas

Palomino-Flores¹,

Arroyo-Acevedo²

2017

Rev. per. med. integr.

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“…Survey etnobotani menunjukkan bahwa biji pepaya secara luas digunakan sebagai herbal untuk managemen beberapa penyakit seperti tidak nyaman pada perut, nyeri, malaria, diabetes, obesitas, dan infeksi (Adeneye, 2009). Biji pepaya kaya kandungan polifenol berupa asam fenolat dan flavonoid, sehingga biji pepaya memiliki aktivitas antiksidan yang tinggi dan Aktivitas antihiperglikemia ekstrak biji pepaya diduga melalui efek menurunkan laju absorpsi glukosa di intestinal, meningkatkan penggunaan glukosa di perifer, menstimulasi kemampuan sel β pankreas untuk memproduksi insulin atau memperbaiki sel β pankreas (Venkateshwarlu, et al, 2013). melalui penelitian ini diharapkan dapat memberikan penjelasan ilmiah tentang mekanisme antioksidan dan antihiperglikemia pada biji pepaya dalam menurunkan kadar glukosa darah pada tikus diabetik.…”

Section: Pendahuluanunclassified

Effect of Papaya Seed Extract (Carica papaya Linn.) on Glucose Transporter 4 (GLUT 4) Expression of Skeletal Muscle Tissue in Diabetic Mice Induced by High Fructose Diet

2017

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“…However, the emphasis on narrowing target specificity has compromised safety; for instance, tackling ulcerogenicity by selective cyclooxygenase (COX) 2 inhibition backfired in the form of cardiovascular ailments [3]. Therefore, addressing multiple targets of inflammation more holistically, in moderation, similar to what is observed with natural products [4], is probably a more viable strategy.…”

Section: Introductionmentioning

confidence: 99%

“…MT drugs, even if they are only partially effective, can regulate the complex equilibrium of wholesome cellular networks rather than single-target drugs [16]. MT strategy is inspired by relatively harmless natural products which afford a comprehensive holistic therapeutic action by working in moderation [4]. MT drugs are more likely to reset the homeostasis upset by chronic pathologies.…”

Section: Introductionmentioning

confidence: 99%

“…Molecules of this kind would probably constitute a Darwinian ''first-inclass'' therapeutic category, which regulates multiple aspects of the evolutionarily conserved, robust and pervasive immune, redox and metabolic processes involved in the complex process of inflammatory repair. Many such natural products with pleiotropic multi-target action have been incorporated into diet (despite negligible calorific value) probably guided by the olfacto-gustatory preferences established over evolutionary timescale [4].…”

Section: Introductionmentioning

confidence: 99%

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Multi-target drugs to address multiple checkpoints in complex inflammatory pathologies: evolutionary cues for novel “first-in-class” anti-inflammatory drug candidates: a reviewer’s perspective

Mathew

Unnikrishnan

2015

Inflamm. Res.

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Inflammation is a complex, metabolically expensive process involving multiple signaling pathways and regulatory mechanisms which have evolved over evolutionary timescale. Addressing multiple targets of inflammation holistically, in moderation, is probably a more evolutionarily viable strategy, as compared to current therapy which addresses drug targets in isolation. Polypharmacology, addressing multiple targets, is commonly used in complex ailments, suggesting the superior safety and efficacy profile of multi-target (MT) drugs. Phenotypic drug discovery, which generated successful MT and first-in-class drugs in the past, is now re-emerging. A multi-pronged approach, which modulates the evolutionarily conserved, robust and pervasive cellular mechanisms of tissue repair, with AMPK at the helm, regulating the complex metabolic/immune/redox pathways underlying inflammation, is perhaps a more viable strategy than addressing single targets in isolation. Molecules that modulate multiple molecular mechanisms of inflammation in moderation (modulating TH cells toward the anti-inflammatory phenotype, activating AMPK, stimulating Nrf2 and inhibiting NFκB) might serve as a model for a novel Darwinian "first-in-class" therapeutic category that holistically addresses immune, redox and metabolic processes associated with inflammatory repair. Such a multimodal biological activity is supported by the fact that several non-calorific pleiotropic natural products with anti-inflammatory action have been incorporated into diet (chiefly guided by the adaptive development of olfacto-gustatory preferences over evolutionary timescales) rendering such molecules, endowed with evolutionarily privileged molecular scaffolds, naturally oriented toward multiple targets.

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Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids

Cited by 31 publications

References 182 publications

Efecto del extracto etanólico de las hojas de Annona muricata L (guanabana) sobre Síndrome metabólico inducido en ratas

Efecto del extracto etanólico de las hojas de Annona muricata L (guanabana) sobre Síndrome metabólico inducido en ratas

Effect of Papaya Seed Extract (Carica papaya Linn.) on Glucose Transporter 4 (GLUT 4) Expression of Skeletal Muscle Tissue in Diabetic Mice Induced by High Fructose Diet

Multi-target drugs to address multiple checkpoints in complex inflammatory pathologies: evolutionary cues for novel “first-in-class” anti-inflammatory drug candidates: a reviewer’s perspective

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