Antibiotic resistance: Evaluation of levofloxacin treatment in acute respiratory tract infections cases at the Tasikmalaya City Health Center, Indonesia

Ramdhani, Danni; Azizah, Shinta Nur; Kusuma, Sri Agung Fitri; Sediana, Dede

doi:10.4103/japtr.japtr_17_20

Cited by 8 publications

(5 citation statements)

References 5 publications

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“…was detected in the sputum sample had higher odds of poor response to an antibiotic trial, even after adjusting for patient characteristics. This may be due to the presence of drug-resistant bacteria ( 32 ). Three of the four pathogens associated with failure to improve on an antibiotic trial were also associated with an increased odds of mortality in the 6 months following the initial assessment: S. pneumoniae/pseudopneumoniae (aOR 5.31, 95% CI 1.29–26.6), M. catarrhalis/nonliquefaciens (aOR 12.1, 95% CI 2.67–72.8), and M. pneumoniae (aOR 34.5 95% CI 4.79–292.3).…”

Section: Discussionmentioning

confidence: 99%

Bacterial pathogens in Xpert MTB/RIF Ultra-negative sputum samples of patients with presumptive tuberculosis in a high TB burden setting: a 16S rRNA analysis

Kebede,

Abebe,

De Boeck

et al. 2024

Microbiol Spectr

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In patients with presumptive tuberculosis (TB) in whom the diagnosis of TB was excluded, understanding the bacterial etiology of lower respiratory tract infections (LRTIs) is important for optimal patient management. A secondary analysis was performed on a cohort of 250 hospitalized patients with symptoms of TB. Bacterial DNA was extracted from sputum samples for Illumina 16S rRNA sequencing to identify bacterial species based on amplicon sequence variant level. The bacterial pathogen most likely to be responsible for the patients’ LRTI could only be identified in a minority (6.0%, 13/215) of cases based on 16S rRNA amplicon sequencing: Mycoplasma pneumoniae ( n = 7), Bordetella pertussis ( n = 2), Acinetobacter baumanii ( n = 2), and Pseudomonas aeruginosa ( n = 2). Other putative pathogens were present in similar proportions of Xpert Ultra-positive and Xpert Ultra-negative sputum samples. The presence of Streptococcus ( pseudo ) pneumoniae appeared to increase the odds of radiological abnormalities (aOR 2.5, 95% CI 1.12–6.16) and the presence of S. ( pseudo ) pneumoniae (aOR 5.31, 95% CI 1.29–26.6) and Moraxella catarrhalis/nonliquefaciens (aOR 12.1, 95% CI 2.67–72.8) increased the odds of 6-month mortality, suggesting that these pathogens might have clinical relevance. M. pneumoniae , B. pertussis, and A. baumanii appeared to be the possible causes of TB-like symptoms. S. ( pseudo ) pneumoniae and M. catarrhalis / nonliquefaciens also appeared of clinical relevance based on 16S rRNA amplicon sequencing. Further research using tools with higher discriminatory power than 16S rRNA sequencing is required to develop optimal diagnostic and treatment strategies for this population. IMPORTANCE The objective of this study was to identify possible bacterial lower respiratory tract infection (LRTI) pathogens in hospitalized patients who were initially suspected to have TB but later tested negative using the Xpert Ultra test. Although 16S rRNA was able to identify some less common or difficult-to-culture pathogens such as Mycoplasma pneumoniae and Bordetella pertussis , one of the main findings of the study is that, in contrast to what we had hypothesized, 16S rRNA is not a method that can be used to assist in the management of patients with presumptive TB having a negative Xpert Ultra test. Even though this could be considered a negative finding, we believe it is an important finding to report as it highlights the need for further research using different approaches.

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Section: Discussionmentioning

confidence: 99%

Bacterial pathogens in Xpert MTB/RIF Ultra-negative sputum samples of patients with presumptive tuberculosis in a high TB burden setting: a 16S rRNA analysis

Kebede,

Abebe,

De Boeck

et al. 2024

Microbiol Spectr

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“…Drug resistance has also emerged in the treatment of respiratory infections. In a recent study, the group of Sediana showed that in the treatment of respiratory infections with levofloxacin, 50% of 142 patients had high levels of resistance, 30.95% had intermediate levels of resistance, and 19.04% of patients were still sensitive to the antibiotic [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?

Fifere¹,

Turin-Moleavin²,

Roșca³

2022

Life

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The aim of this study is to evaluate the efficiency of protocatechuic acid (PCA) in enhancing the commonly used drugs used to fight against nosocomial infection. These drugs are represented by routinely used antibiotics, synthetic chemotherapeutic agents with an antimicrobial spectrum, and antifungals. Three concentrations of PCA were added to 12 types of commercial disks used for antibiotic and antifungal susceptibility and tested against bacterial and yeast strains represented by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. The results proved that PCA increased up to 50% of the antibacterial activity, especially that of levofloxacin against Staphylococcus aureus and Escherichia coli. These formulations will lead to new drug design ideas containing a smaller amount of antibiotics with the same effectiveness.

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“…The study reported by Ramdhani et al, regarding the management of ARTIs patients in a public health center of Tasikmalaya, Indonesia, described a fairly serious case of antibiotic resistance. The use of several antibiotics showed decreased effectiveness with a high resistance value, including amoxicillin (70.25%), levofloxacin (50.0%), ciprofloxacin (43.03%) 11 – 13 .…”

Section: Introductionmentioning

confidence: 99%

Comparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in Indonesia

Ramdhani

Kusuma

Sediana³

et al. 2021

Sci Rep

Self Cite

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Antibiotic resistance is a serious threat that occurs globally in the health sector due to increased consumption of inappropriate antibiotics. Guidelines for prescribing antibiotics for ARTIs have been issued in general practice to promote rational antibiotic prescribing. This study was conducted to compare the effectiveness of cefixime and tetracycline as a solution to improve monitoring of appropriate antibiotic use in the treatment of ARTIs. All stock isolates were rejuvenated first, and cultured on standard media and Kirby–Bauer disc diffusion method was used for susceptibility testing in accordance with the Clinical and Laboratory Standard Institute’s (CLSI) recommendations. Identification of bacteria from a single isolate was carried out to determine which bacteria were resistant to cefixime and tetracycline. A total of 466 single isolates of bacteria were analyzed, which showed a percentage of resistance to cefixime 38.0%, and tetracycline 92.86%. Bacterial isolates were resistant to cefixime and tetracycilne was a genus of Haemophilus, Streptococcus, Corynebacterium, Staphylococcus, and bordetella. Cefixime compared to tetracycline was proven to be superior in terms of the effectiveness of ARIs treatment.

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Antibiotic resistance: Evaluation of levofloxacin treatment in acute respiratory tract infections cases at the Tasikmalaya City Health Center, Indonesia

Cited by 8 publications

References 5 publications

Bacterial pathogens in Xpert MTB/RIF Ultra-negative sputum samples of patients with presumptive tuberculosis in a high TB burden setting: a 16S rRNA analysis

Bacterial pathogens in Xpert MTB/RIF Ultra-negative sputum samples of patients with presumptive tuberculosis in a high TB burden setting: a 16S rRNA analysis

Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?

Comparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in Indonesia

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