Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?

Abstract

The aim of this study is to evaluate the efficiency of protocatechuic acid (PCA) in enhancing the commonly used drugs used to fight against nosocomial infection. These drugs are represented by routinely used antibiotics, synthetic chemotherapeutic agents with an antimicrobial spectrum, and antifungals. Three concentrations of PCA were added to 12 types of commercial disks used for antibiotic and antifungal susceptibility and tested against bacterial and yeast strains represented by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. The results proved that PCA increased up to 50% of the antibacterial activity, especially that of levofloxacin against Staphylococcus aureus and Escherichia coli. These formulations will lead to new drug design ideas containing a smaller amount of antibiotics with the same effectiveness.

Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatment with Polygonum capitatum Buch.-Ham. ex D. Don extracts

“…The antibacterial, anti-inflammatory, antioxidant and analgesic activities of PCE, GA and PCA are helpful to improve the efficacy of CIP in the treatment of infectious diseases of urogenital system (Liao et al, 2011;Khan et al, 2015;Choubey et al, 2018;Song et al, 2020;Bai et al, 2021). The in vitro study proves that PCA increased up to 50% of the antibacterial activity, especially that of levofloxacin against Staphylococcus aureus and Escherichia coli (Fifere et al, 2022).…”