Antibacterial effects of titanium embedded with silver nanoparticles based on electron-transfer-induced reactive oxygen species

Eradicating Multidrug‐Resistant Bacteria Rapidly Using a Multi Functional g‐C3N4@ Bi2S3 Nanorod Heterojunction with or without Antibiotics

“…In fact, increased endogenous oxidative level is an important stress of light‐activated nanocomposites that triggers physiological disorder in bacteria . To some extent, it reflects the antibacterial capacity of nanocomposites . This over‐oxidative environment in bacteria was responsible for physiological perturbations, such as membrane depolarization, ATP metabolic disorders, and protein or DNA/RNA release, which can be attributed to the membrane permeability changing .…”

Self-defending additively manufactured bone implants bearing silver and copper nanoparticles

“…The underlying mechanism for the altered Ag and Cu ion release was not studied, but may stem from the micro-galvanic coupling processes at the implant surface. 68 Next to antibacterial leaching activity, antibacterial surfaces require contact-killing properties to extinguish adherent bacteria. ROS are known to play an important role in this process due to their extremely reactive nature, which also results in a short life-span.…”

“…Previous studies have indicated the importance of ROS in bacterial killing by antibacterial surfaces containing either Ag or Cu. [68][69][70][71] We, therefore, investigated the generation of ROS from the implants with EPR and observed that PEO biofunctionalization resulted in the formation of both hydroxyl and methyl radicals. Furthermore, Ag incorporated into the implant surface enhanced the generation of hydroxyl radicals even further, whereas Cu NPs did not.…”

Preparing and immobilizing antimicrobial osteogenic growth peptide on titanium substrate surface

“…Benefited from good biocompatibility, corrosion resistance, light weight, and excellent mechanical properties, native titanium (Ti) and its alloys have been extensively used in orthopedics field . However, the inherent bioinertness and potential bacterial infection risk of bare Ti implants would weaken the osseointegration between bone tissue and implant surface, and even given rise to revision arthroplasty . Actually, according to previous research, aseptic loosening and infection are two leading causes of implant failure, bringing great physical pain and financial burden to patients .…”

“…[4][5][6] However, the inherent bioinertness and potential bacterial infection risk of bare Ti implants would weaken the osseointegration between bone tissue and implant surface, and even given rise to revision arthroplasty. [7][8][9] Actually, according to previous research, aseptic loosening and infection are two leading causes of implant failure, bringing great physical pain and financial burden to patients. [10][11][12][13] In particular, as pointed out by Gristina of the "race for the surface, " aseptic loosening and infection are intimately related.…”