Eradicating Multidrug‐Resistant Bacteria Rapidly Using a Multi Functional g‐C3N4@ Bi2S3 Nanorod Heterojunction with or without Antibiotics

Li, Yuan; Liu, Xiangmei; Tan, Lei; Cui, Zhenduo; Jing, Doudou; Yang, Xianjin; Liang, Yanqin; Li, Zhaoyang; Zhu, Shengli; Zheng, Yufeng; Yeung, Kelvin Wai Kwok; Zheng, Dong; Wang, Xiaochang C.; Wu, S. L.

doi:10.1002/adfm.201900946

Cited by 151 publications

(56 citation statements)

References 50 publications

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“…As shown in Fig. 4 e,the synergistic effects of the generated hyperthermia and ROS by the TiO 2 nanostructures during the irradiation with 808 nm NIR light increase the bacterial membrane permeability [ 55 , 56 ] and the combined actions of hyperthermia, ROS, and puncturing by the nanorod disrupt the cell membranes causing leakage of cytoplasmic contents and eventual bacterial death [ 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant

Zhang

Chai

et al. 2021

Bioactive Materials

120

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Treatment of implant-associated infection is becoming more challenging, especially when bacterial biofilms form on the surface of the implants. Developing multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic effects are superior to those based on single modality due to avoiding the adverse effects arising from the latter. In this work, TiO 2 nanorod arrays in combination with irradiation with 808 near-infrared (NIR) light are proven to eradicate single specie biofilms by combining photothermal therapy, photodynamic therapy, and physical killing of bacteria. The TiO 2 nanorod arrays possess efficient photothermal conversion ability and produce a small amount of reactive oxygen species (ROS). Physiologically, the combined actions of hyperthermia, ROS, and puncturing by nanorods give rise to excellent antibacterial properties on titanium requiring irradiation for only 15 min as demonstrated by our experiments conducted in vitro and in vivo . More importantly, bone biofilm infection is successfully treated efficiently by the synergistic antibacterial effects and at the same time, the TiO 2 nanorod arrays improve the new bone formation around implants. In this protocol, besides the biocompatible TiO 2 nanorod arrays, an extra photosensitizer is not needed and no other ions would be released. Our findings reveal a rapid bacteria-killing method based on the multiple synergetic antibacterial modalities with high biosafety that can be implemented in vivo and obviate the need for a second operation. The concept and antibacterial system described here have large clinical potential in orthopedic and dental applications.

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Section: Resultsmentioning

confidence: 99%

Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant

Zhang

Chai

et al. 2021

Bioactive Materials

120

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“…A higher photothermal temperature is necessary for inactivating bacteria effectively during photothermal therapy, but such a temperature will inevitably damage normal cells and tissues [ 6 , 41 ]. Therefore, synergistic action through two or more therapeutic modes has been proven to be more effective for killing bacteria—such as photodynamic therapy paired with Ag ions [ 42 , 43 ] or with photothermal action [ [44] , [45] , [46] , [47] ], as well as combined photodynamic and photothermal therapy paired with Zn 2+ [ 48 ], Cu 2+ [ 49 ], etc.…”

Section: Introductionmentioning

confidence: 99%

Ag3PO4 decorated black urchin-like defective TiO2 for rapid and long-term bacteria-killing under visible light

Liu

Zheng

et al. 2021

Bioactive Materials

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Both phototherapy via photocatalysts and physical puncture by artificial nanostructures are promising substitutes for antibiotics when treating drug-resistant bacterial infectious diseases. However, the photodynamic therapeutic efficacy of photocatalysts is seriously restricted by the rapid recombination of photogenerated electron–hole pairs. Meanwhile, the nanostructures of physical puncture are limited to two-dimensional (2D) platforms, and they cannot be fully used yet. Thus, this research developed a synergistic system of Ag 3 PO 4 nanoparticles (NPs), decorated with black urchin-like defective TiO 2 (BU–TiO 2-X /Ag 3 PO 4 ). These NPs had a decreased bandgap compared to BU-TiO 2-X , and BU-TiO 2-X /Ag 3 PO 4 (3:1) exhibited the lowest bandgap and the highest separation efficiency for photogenerated electron–hole pairs. After combination with BU-TiO 2-X , the photostability of Ag 3 PO 4 improved because the oxygen vacancy of BU-TiO 2-X retards the reduction of Ag + in Ag 3 PO 4 into Ag 0 , thus reducing its toxicity. In addition, the nanospikes on the surface of BU-TiO 2-X can, from all directions, physically puncture bacterial cells, thus assisting the hybrid's photodynamic therapeutic effects, alongside the small amount of Ag + released from Ag 3 PO 4 . This achieves synergy, endowing the hybrid with high antibacterial efficacy of 99.76 ± 0.15% and 99.85 ± 0.09% against Escherichia coli and Staphylococcus aureus , respectively, after light irradiation for 20 min followed by darkness for 12 h. It is anticipated that these findings may bring new insight for developing synergistic treatment strategies against bacterial infectious diseases or pathogenic bacterial polluted environments.

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“…Next, 100 μL A-LIP-PEG and LIP-PEG were placed on agar plates and incubated at 37°C for 24 h. After incubation, bacterial inhibition halos around the lipo-hydrogel samples were observed, and the diameter of the bacterial inhibition halos was measured. To observe the live/dead status of the bacteria experimentally, a fluorescence-based cell live/dead assay was carried out 28,29 . A total of 100 μL A-LIP-PEG and LIP-PEG were immersed in 1000 μL bacterial culture medium with a bacterial concentration of approximately 1 × 10 8 CFUs/ mL (CFU: colony forming unit).…”

Section: Antibacterial Performance Of Lipo-hydrogelsmentioning

confidence: 99%

Adhesive liposomes loaded onto an injectable, self-healing and antibacterial hydrogel for promoting bone reconstruction

et al. 2019

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Loading hydrogels with bioactive agents is an important method for expanding the functional application of hydrogels. However, how to improve the local administration and slow release of drugs from a hydrogel is a challenge when using hydrogels loaded with drugs. In this paper, we first developed adhesive liposomes (A-LIP) loaded with BMP-2. Then, we incorporated the A-LIP into PEG hydrogels based on the coordinated cross-linking principle of SH-PEG and Ag + , fabricating an injectable, antibacterial and self-healing multifunctional drug delivery system. The adhesive lipo-hydrogel (A-LIP-PEG) fabricated by mixing PEG hydrogels and adhesive liposomes can be locally injected into an osteoporotic fracture and bone marrow cavity, where A-LIP-PEG can release adhesive liposomes that adhere to the bone injury area and promote bone reconstruction. Based on the principle of electrostatic attraction, tissue nonspecific A-LIP were fabricated by grafting octadecylamine onto liposomes. Because of the coordination and crosslinking of thiolated polyethylene (SH-PEG) and Ag + , the A-LIP-PEG showed excellent injectability and self-healing properties; further, because of the presence of Ag + , the A-LIP-PEG showed effective inhibition of S. aureus and Escherichia coli. The liposomes released by the A-LIP-PEG were able to adhere to tissue. In vitro studies showed that A-LIP-PEG significantly promoted osteogenic differentiation and had no significant effect on cell proliferation. Compared with common lipo-hydrogel (LIP-PEG), the A-LIP-PEG had better tissue adhesion in vivo, which led to better osteogenic differentiation and faster local bone remodeling of osteoporotic fractures in rats. This research developed a novel hydrogel system with adhesive liposomes to expand the application of hydrogels.

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Eradicating Multidrug‐Resistant Bacteria Rapidly Using a Multi Functional g‐C₃N₄@ Bi₂S₃ Nanorod Heterojunction with or without Antibiotics

Cited by 151 publications

References 50 publications

Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant

Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant

Ag3PO4 decorated black urchin-like defective TiO2 for rapid and long-term bacteria-killing under visible light

Adhesive liposomes loaded onto an injectable, self-healing and antibacterial hydrogel for promoting bone reconstruction

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