Self-defending additively manufactured bone implants bearing silver and copper nanoparticles

Hengel, I.A.J. van; Tierolf, Melissa W. A. M.; Valerio, V.; Minneboo, Michelle; Fluit, Ad C.; Fratila‐Apachitei, Lidy E.; Apachitei, I.; Zadpoor, Amir A.

doi:10.1039/c9tb02434d

Cited by 73 publications

(51 citation statements)

References 75 publications

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“…Hengel et al explored the synergistic antibacterial capabilities of Ag and Cu NPs by functionalizing TiO 2 surfaces with those NPs. 69 They observed a 10-fold reduction in the concentration of silver ions while sustaining the same level of antibacterial activity on MRSA. Their work sheds light on how the synergistic antibacterial properties of some metal ions can be harnessed to design more-biocompatible implants with efficient antibacterial effects.…”

Section: Metal Ion Releasementioning

confidence: 90%

“…For example, ionic solutions/colloidal suspensions of metallic NPs of Ag, Cu, and Li were incorporated into some dental materials, and the resulting metal ions had an antibacterial effect on Staphylococcus aureus (S. aures). 64 Other application include pit and fissure sealants designed with antibacterial properties, 65 wound healing, [66][67][68] implant technology, 69,70 improved disinfection materials, 71 eco-friendly design of NPs with antibacterial properties, 72 and antibacterial-Ag/plasma polymer nanocomposites for cotton fabrics, 73 among others. The antibacterial capabilities of Ag ions can be preserved while the harmful effect on biological environment is reduced by synthesizing Ag with hydroxyapatite from phosphorus-deficient precursors using carbonate substitution, Ag containing calcium phosphate, and Ag NPs carriers of hydroxyapatite powder.…”

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confidence: 99%

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Emerging Trends in Nanomaterials for Antibacterial Applications

Yougbaré¹,

Mutalik²,

Okoro³

et al. 2021

IJN

117

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Around the globe, surges of bacterial diseases are causing serious health threats and related concerns. Recently, the metal ion release and photodynamic and photothermal effects of nanomaterials were demonstrated to have substantial efficiency in eliminating resistance and surges of bacteria. Nanomaterials with characteristics such as surface plasmonic resonance, photocatalysis, structural complexities, and optical features have been utilized to control metal ion release, generate reactive oxygen species, and produce heat for antibacterial applications. The superior characteristics of nanomaterials present an opportunity to explore and enhance their antibacterial activities leading to clinical applications. In this review, we comprehensively list three different antibacterial mechanisms of metal ion release, photodynamic therapy, and photothermal therapy based on nanomaterials. These three different antibacterial mechanisms are divided into their respective subgroups in accordance with recent achievements, showcasing prospective challenges and opportunities in clinical, environmental, and related fields.

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Section: Metal Ion Releasementioning

confidence: 90%

mentioning

confidence: 99%

Emerging Trends in Nanomaterials for Antibacterial Applications

Yougbaré¹,

Mutalik²,

Okoro³

et al. 2021

IJN

117

View full text Add to dashboard Cite

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“…A combination of antimicrobial agents provides a way to solve these two problems. The combination of two or more antibacterial agents has a synergistic antibacterial effect and reduces the minimum inhibitory or bactericidal concentration [169,180,200]. For example, the combination of Ag and Zn can reduce the required concentration of Ag by two orders of magnitude, while maintaining the same antibacterial activity, greatly reducing cytotoxicity [169].…”

Section: Comparisonmentioning

confidence: 99%

Toward Bactericidal Enhancement of Additively Manufactured Titanium Implants

et al. 2021

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Implant-associated infections (IAIs) are among the most intractable and costly complications in implant surgery. They can lead to surgery failure, a high economic burden, and a decrease in patient quality of life. This manuscript is devoted to introducing current antimicrobial strategies for additively manufactured (AM) titanium (Ti) implants and fostering a better understanding in order to pave the way for potential modern high-throughput technologies. Most bactericidal strategies rely on implant structure design and surface modification. By means of rational structural design, the performance of AM Ti implants can be improved by maintaining a favorable balance between the mechanical, osteogenic, and antibacterial properties. This subject becomes even more important when working with complex geometries; therefore, it is necessary to select appropriate surface modification techniques, including both topological and chemical modification. Antibacterial active metal and antibiotic coatings are among the most commonly used chemical modifications in AM Ti implants. These surface modifications can successfully inhibit bacterial adhesion and biofilm formation, and bacterial apoptosis, leading to improved antibacterial properties. As a result of certain issues such as drug resistance and cytotoxicity, the development of novel and alternative antimicrobial strategies is urgently required. In this regard, the present review paper provides insights into the enhancement of bactericidal properties in AM Ti implants.

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“…Nanoparticles (NPs) have chemical and physical characteristic properties ascribed to their comparatively small size and high surface-area-to-volume ratio. Copper nanoparticles—amongst various metallic NPs—show, i.e., high selectivity [ 16 ], catalytic activity [ 17 , 18 ], very good electrical conductivity [ 19 ], as well as antibacterial capacitance [ 20 ], and a broad spectrum of antimicrobial activity against different micro-organisms [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Micro- and Nanoscale Spectroscopic Investigations of Threonine Influence on the Corrosion Process of the Modified Fe Surface by Cu Nanoparticles

et al. 2020

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The work presents a comprehensive vibrational analysis of the process of adsorption of threonine (Thr) onto an Fe surface with deposited Cu nanoparticles (NPs) (of about 4–5 nm in size) in a corrosive environment. The application of surface-enhanced Raman spectroscopy (SERS) and surface-enhanced infrared absorption spectroscopy (SEIRA) provides the opportunity for detailed description of adsorption geometry of amino acid onto a metal surface. The combination of conventional infrared spectroscopy (IR) with atomic force microscopy (AFM) resulted in a nano-SEIRA technique which made it possible to provide a precise description of adsorbate binding to the metal surface. The studies presented confirmed that there is a very good correlation between the spectra recorded by the SERS, SEIRA, and nano-SEIRA techniques. Threonine significantly influenced the process of corrosion of the investigated surface due to the existing strong interaction between the protonated amine and carboxylate groups and the CuNPs deposited onto the Fe surface. In addition, the application of two polarization modulations (s and p) in nano-SEIRA allows subtle changes to be observed in the molecule geometry upon adsorption, with the carboxylate group of Thr being almost horizontally oriented onto the metal surface; whereas the amine group that contains nitrogen is oriented perpendicular to this surface.

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Self-defending additively manufactured bone implants bearing silver and copper nanoparticles

Abstract: Exploiting the synergistic antibacterial behavior of Ag and Cu nanoparticles in self-defending implants.

Cited by 73 publications

References 75 publications

Emerging Trends in Nanomaterials for Antibacterial Applications

Emerging Trends in Nanomaterials for Antibacterial Applications

Toward Bactericidal Enhancement of Additively Manufactured Titanium Implants

Micro- and Nanoscale Spectroscopic Investigations of Threonine Influence on the Corrosion Process of the Modified Fe Surface by Cu Nanoparticles

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