Emerging Trends in Nanomaterials for Antibacterial Applications

Yougbaré, Sibidou; Mutalik, Chinmaya; Okoro, Goodluck; Lin, I‐Hsin; Krisnawati, Dyah Ika; Jazidie, Achmad; Nuh, Mohammad; Chang, Che-Chang; Kuo, Tsung‐Rong

doi:10.2147/ijn.s328767

Cited by 117 publications

(98 citation statements)

References 242 publications

(226 reference statements)

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“…The controllable metal ions release of metal/metal oxide nanoparticles presents an opportunity to eliminate resistance and surges of bacteria, and to enhance their antibacterial activities leading to potential clinical applications. 7 Metal nanoparticles, such as AuNPs and Cu2O, showed good inhibitory effects against bacteria and fungi. 8–10 Ag nanospheres with sustained and controllable release of Ag ions exhibited significant antibacterial ability and also showed good cytocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Plasma SiOx:H Nanocoatings to Enhance the Antibacterial and Anti-Inflammatory Properties of Biomaterials

Ye¹,

Yu²,

Dong³

et al. 2022

IJN

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Purpose To evaluate the antibacterial and anti-inflammatory properties of SiOx:H nanocoatings using a plasma-deposition technique. Materials and Methods Four groups of SiOx:H nanocoatings were prepared by plasma nanocoating technique using different deposition gases and durations, specifically trimethylsilane (TMS) for groups A1 and A2 and a mixture of TMS and oxygen for groups B1 and B2. Changes in surface chemistry and physical properties were measured. Staphylococcus aureus and Streptococcus mutans were cultured on plasma SiOx:H nanocoatings to evaluate antibacterial and antibiofilm formation activities. Human gingival fibroblasts (HGFs) and HaCaT human keratinocytes were cultured and stimulated with tumor necrosis factor-α (TNF-α). Cell viability was measured using a Cell Counting Kit-8 (CCK-8) assay. Quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) were used to evaluate anti-inflammatory properties, including the mRNA and protein levels of inflammatory mediators and proinflammatory cytokines. Results The carbon content was dominant in group A nanocoatings and the oxygen and silicon elements were dominant in group B nanocoatings. Groups A2 and B2 were approximately threefold thicker than groups A1 and B1. The plasma SiO x :H nanocoatings decreased bacterial growth and biofilm formation by 30–70% ( p < 0.05). Scanning electron microscopy (SEM) revealed damaged biofilm structures. Moreover, the antibacterial properties of group B were greater than group A, and the antibacterial properties of groups A2 and B2 were more effective than A1 and B1, respectively. CCK-8 assays revealed the plasma SiOx:H nanocoatings had good biocompatibility. Furthermore, under TNF-α-induced inflammation, the mRNA and protein levels of interleukin-6, interleukin-8, cyclooxygenase-2, and monocyte chemoattractant protein-1 were downregulated in the plasma SiOx:H nanocoating groups ( p < 0.05). Conclusion Plasma SiOx:H nanocoatings exerted antibacterial and anti-inflammatory effects with excellent biocompatibility. Therefore, the plasma SiOx:H nanocoating technique has potential for implant materials and other medical devices.

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Section: Introductionmentioning

confidence: 99%

Plasma SiOx:H Nanocoatings to Enhance the Antibacterial and Anti-Inflammatory Properties of Biomaterials

Ye¹,

Yu²,

Dong³

et al. 2022

IJN

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“…The release of metal ions and the direct interaction between the surface of NPs and bacteria are among the most investigated antibacterial mechanisms of NPs [ 84 , 85 ]. Therefore, the valence states of the NPs providing the information about the ratio between metallic and oxidized states of the nanoparticles and their influence on the antibacterial effect are usually investigated.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activity of Silver and Gold Particles Formed on Titania Thin Films

et al. 2022

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Metal-based nanoparticles with antimicrobial activity are gaining a lot of attention in recent years due to the increased antibiotics resistance. The development and the pathogenesis of oral diseases are usually associated with the formation of bacteria biofilms on the surfaces; therefore, it is crucial to investigate the materials and their properties that would reduce bacterial attachment and biofilm formation. This work provides a systematic investigation of the physical-chemical properties and the antibacterial activity of TiO2 thin films decorated by Ag and Au nanoparticles (NP) against Veillonella parvula and Neisseria sicca species associated with oral diseases. TiO2 thin films were formed using reactive magnetron sputtering by obtaining as-deposited amorphous and crystalline TiO2 thin films after annealing. Au and Ag NP were formed using a two-step process: magnetron sputtering of thin metal films and solid-state dewetting. The surface properties and crystallographic nature of TiO2/NP structures were investigated by SEM, XPS, XRD, and optical microscopy. It was found that the higher thickness of Au and Ag thin films results in the formation of the enlarged NPs and increased distance between them, influencing the antibacterial activity of the formed structures. TiO2 surface with AgNP exhibited higher antibacterial efficiency than Au nanostructured titania surfaces and effectively reduced the concentration of the bacteria. The process of the observation and identification of the presence of bacteria using the deep learning technique was realized.

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“…[ 70 ] With the advancement of nanotechnology, a slew of well‐designed antimicrobial nPTT systems have been developed either by coupling conventional photothermal agents with nanomaterials to improve their photostability and pharmacokinetics, or by synthesizing and exploiting novel nanoparticles with higher photothermal conversion efficiency. [ 71 ]…”

Section: Optical Stimulation‐based Npasmentioning

confidence: 99%

Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

Jia

Wang

et al. 2022

Advanced Science

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The emergence of bacterial resistance due to the evolution of microbes under antibiotic selection pressure, and their ability to form biofilm, has necessitated the development of alternative antimicrobial therapeutics. Physical stimulation, as a powerful antimicrobial method to disrupt microbial structure, has been widely used in food and industrial sterilization. With advances in nanotechnology, nanophysical antimicrobial strategies (NPAS) have provided unprecedented opportunities to treat antibiotic-resistant infections, via a combination of nanomaterials and physical stimulations. In this review, NPAS are categorized according to the modes of their physical stimulation, which include mechanical, optical, magnetic, acoustic, and electrical signals. The biomedical applications of NPAS in combating bacterial infections are systematically introduced, with a focus on their design and antimicrobial mechanisms. Current challenges and further perspectives of NPAS in the clinical treatment of bacterial infections are also summarized and discussed to highlight their potential use in clinical settings. The authors hope that this review will attract more researchers to further advance the promising field of NPAS, and provide new insights for designing powerful strategies to combat bacterial resistance.

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Emerging Trends in Nanomaterials for Antibacterial Applications

Cited by 117 publications

References 242 publications

Plasma SiOx:H Nanocoatings to Enhance the Antibacterial and Anti-Inflammatory Properties of Biomaterials

Plasma SiOx:H Nanocoatings to Enhance the Antibacterial and Anti-Inflammatory Properties of Biomaterials

Antibacterial Activity of Silver and Gold Particles Formed on Titania Thin Films

Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

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