An Umeclidinium membrane sensor; Two-step optimization strategy for improved responses

Yehia, Ali M.; Monir, Hany H.

doi:10.1016/j.talanta.2017.05.019

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…36 In addition, the lipophilicity of anionic exchangers has a substantial impact on the Nernstian slope and the quantitation limit because it impedes the extraction of the counter ions. 37 Five anionic exchangers with different lipophilicity were tested separately (TDA, log P = 24.33; DTA, Log P = 6.28; DDA; TOA, log P = 15.26; MTA, log P = 11.26, or DDA log P = 12.56) 38 (Sensors 1-5) (Table I). The formulated membranes had a thickness of ca.…”

Section: Resultsmentioning

confidence: 99%

Green Assay of Tolmetin Sodium Using Solid Contact Potentiometric Sensor Doped with Ionophore and Supported with Docking Study: Application to Human Plasma and Pharmaceutical Formulations

Mahrous

Mabrouk

Habib

et al. 2023

J. Electrochem. Soc.

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Tolmetin sodium (TOL) is a non-steroidal anti-inflammatory drug used to treat arthritis. Potentiometric ion selective electrodes (ISEs) bypass sample pre-treatment, high-tech apparatus, and toxic chemicals. The current study aimed to develop and validate a potentiometric analyser for the direct assay of TOL in pharmaceutical dosage form and human plasma. We designed an experimental approach to determine the factors that affect the performance of the developed sensor. A solid contact glassy carbon electrode was utilized as a support for the developed sensor. The interaction of TOL with several ionophore was studied using molecular docking. The optimized sensor was fabricated using dioctyl phthalate as plasticizer, tetra dodecyl ammonium bromide as anion exchanger, and β cyclodextrin as ionophore. The sensor achieved -58.78 Nernstian response within 1.00‎×‎10-2 to 2.00‎×‎10-6 mol/L linear range,1.56 ‎×‎10-6 mol/L LOD, and fast response within 7 s. The greenness of the proposed method was assessed using the Analytical Eco-scale and the "Green Analytical Procedure Index" metric tools and compared with the reported methods and gained high scores. The proposed method has several advantages in encouraging quality control and clinical labs to routinely use the developed sensor in the assay of TOL in pharmaceutical dosage forms and human plasma.

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Section: Resultsmentioning

confidence: 99%

Green Assay of Tolmetin Sodium Using Solid Contact Potentiometric Sensor Doped with Ionophore and Supported with Docking Study: Application to Human Plasma and Pharmaceutical Formulations

Mahrous

Mabrouk

Habib

et al. 2023

J. Electrochem. Soc.

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“…As a result, a lipophilic cation exchanger (TpClPB) was incorporated in our fabricated membrane. CX6 was also employed as an ionophore/host molecule to act as a receptor for the drug of interest [33]. In addition, PANI was incorporated as hydrophobic transducing nanoparticles at solid contact/ion‐selective membrane interface to guard against formation of the undesired water layer [16].…”

Section: Resultsmentioning

confidence: 99%

A New Comparative Potentiometric Method for Analysis of Omarigliptin Using Three Different Sensors

et al. 2022

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This work represents first attempt for potentiometric determination of the most recent antidiabetic; omarigliptin. Three sensors, employing potassium tetrakis (p-chlorophenyl) borate as a lipophilic cation exchanger, were developed and compared. One liquid contact ionselective electrode and two carbon paste-based solid contact ones, plain one and another one modified with polyaniline nanoparticles, were employed. Performances of fabricated sensors were assessed as per IUPAC recommendations. Incorporation of hydrophobic polyaniline nanoparticles as ion-to-electron transducer layer at solid contact/ion-sensitive membrane interface enhanced sensitivity and stability of the third sensor showing LOD of 2.5 × 10 À 7 mol L À 1 and slope of 58.57 mV decade À 1 . The three sensors were applied for omarigliptin determination in presence of its degradation products, in dosage form and spiked human plasma.

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“…Recent achievements have been combined with multiple visions for the sensor optimization, where factors should work in a harmony to generate a reliable and consistent sensor performance [16][17][18]. Liquid membrane and solid contact senor assemblies of several PVC membranes with different composition were fabricated to investigate the influence of the anion exchangers, ionophores and sensor assembly on the sensor performance.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Effect of four Hosting Ionophores on the Performance of Anion Selective Potentiometric Sensor

Saad

Essam

2019

Electroanalysis

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A systematically designed practical approach was carried out for the optimization of an anion selective electrode for the determination of an anionic laxative, docusate sodium (DS). The PVC membrane composition and the sensor assembly were systematically optimized. Different sensors were fabricated using tetradodecylammonium bromide (TDAB), tridodecylmethylammonium bromide, tetraheptylammonium bromide as ion exchangers. The effect of ionophore was evaluated using four different host‐guest ionophores, namely; calix[8]arene, β‐cylodextrin, hydroxypropyl‐β‐cylodextrin and carboxymethyl‐β‐cylodextrin to reach the optimum membrane composition. Sensors were constructed in both liquid membrane and solid contact sensor‐assemblies. The slope, linear range, LOQ and response time for each sensor was calculated to assess their performance characteristics. Best Nernstian slope of −61.38 mV/decade and lowest quantification limit of 7.62×10−7 M was achieved by the sensor containing TDAB as ion exchanger and Calix[8]arene as ionophore in the PVC matrix using the gold wire solid contact sensor assembly. Electrode selectivity was assured in the presence of DS potential degradation product, common interfering ions and industrial excipients of tablet and gel formulations. Validation was carried out regarding the ICH validation parameters.

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An Umeclidinium membrane sensor; Two-step optimization strategy for improved responses

Cited by 9 publications

References 36 publications

Green Assay of Tolmetin Sodium Using Solid Contact Potentiometric Sensor Doped with Ionophore and Supported with Docking Study: Application to Human Plasma and Pharmaceutical Formulations

Green Assay of Tolmetin Sodium Using Solid Contact Potentiometric Sensor Doped with Ionophore and Supported with Docking Study: Application to Human Plasma and Pharmaceutical Formulations

A New Comparative Potentiometric Method for Analysis of Omarigliptin Using Three Different Sensors

Evaluating the Effect of four Hosting Ionophores on the Performance of Anion Selective Potentiometric Sensor

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