A New Comparative Potentiometric Method for Analysis of Omarigliptin Using Three Different Sensors

Abstract

This work represents first attempt for potentiometric determination of the most recent antidiabetic; omarigliptin. Three sensors, employing potassium tetrakis (p-chlorophenyl) borate as a lipophilic cation exchanger, were developed and compared. One liquid contact ionselective electrode and two carbon paste-based solid contact ones, plain one and another one modified with polyaniline nanoparticles, were employed. Performances of fabricated sensors were assessed as per IUPAC recommendations. Incorporation of hydrophobic polyaniline nanoparticles as ion-to-electron transducer layer at solid contact/ion-sensitive membrane interface enhanced sensitivity and stability of the third sensor showing LOD of 2.5 × 10 À 7 mol L À 1 and slope of 58.57 mV decade À 1 . The three sensors were applied for omarigliptin determination in presence of its degradation products, in dosage form and spiked human plasma.

A trimodal detection paper chip for undisclosed drug “sibutramine” in nutraceuticals

“…A plasticizer is also essential for construction of a PVC sensing membrane to allow ionic species to freely flow throughout the membrane matrix, and hence improve membrane conductivity. 40 The selection of DBP as a plasticizer in this study helped in obtaining ideal monovalent cations' Nernstian slope. This may be attributed to the relatively high dielectric constant in addition to its ability to enhance the membrane polarity compared to the others.…”

“…For the indicator electrode, MWCNTs-SDS solution was utilized to exploit the high hydrophobicity and conductivity of MWCNTs to safeguard against water layer formation as well as enhance reproducibility of potential readings. 40 The presence of a basic tertiary amine group, in the SBT structure, suggested the use of NaTFPB in the PVC sensing membrane as a cation exchanger. NaTFPB is a high-lipophilic exchanger and physically compatible with the polymeric matrix.…”

Application of ionic liquids and various carbon materials in reference electrodes with carbon paste‐based transducers

“…Such a carbon paste turned out to be an attractive conductive substrate for electrode preparation, due to simplicity and low cost of preparation, low resistance and fast electrochemical response [27]. Carbon paste electrodes are most often used for voltametric measurements [28,29], however potentiometric devices with carbon paste transducers were also reported [30][31][32]. Typically carbon paste electrodes are constructed by filling a cavity of the electrode body with a carbon paste and smoothing it on a clean paper until it has a shiny appearance, which results in a geometry of a disc electrode.…”

Stability indicating potentiometric method for the determination of palonosetron HCl using two different sensors

“…This provides them their unique cavity-shaped configuration that leads to formation of typical host-guest complexes with different compounds depending on some factors, such as; cavitysize, conformation and substituents. In nutshell, calixarenes are suitable for a variety of applications in ISEs fabrication 22,29,30 .Here, we develop the first ISE for the potentiometric determination of PALO. We also exploit the advantages of selectivity enhancement, related to calix [8]arene incorporation in potentiometric ISE, in order to demonstrate its use as a stability-indicating one.…”

“…This provides them their unique cavity-shaped configuration that leads to formation of typical host-guest complexes with different compounds depending on some factors, such as; cavitysize, conformation and substituents. In nutshell, calixarenes are suitable for a variety of applications in ISEs fabrication 22,29,30 .…”