A multichannel high-resolution single-slope analogue-to-digital converter (SS ADC) is presented that automatically compensates for process, voltage and temperature variations, as well as for radiation effects, in order to be used in extreme environmental conditions. The design combines an efficient implementation by using a feedback loop that ensures an inherently monotonic and very accurate ramp generation, with high levels of configurability in terms of resolution and conversion rate, as well as input voltage range. The SS ADC was designed in a standard 0.35 µm CMOS technology. Experimental measurements of the performance and stability against radiation and temperature are presented to verify the proposed approach.Introduction: Single-slope analogue-to-digital converters (SS ADCs) are widely used in many multichannel data acquisition applications by implementing parallel readout architectures. The ramp generator is a key element in this conversion scheme, given the direct relationship between its performance and the ADC transfer characteristic. When medium to high resolutions are the aim, process, voltage and temperature (PVT) and ageing variations can limit the accuracy of the SS ADC. Moreover, in space environments, circuits are required to operate in an extended temperature range and also to deal with the total ionising dose (TID) radiation effects that degrade the DC and AC performance characteristics with a gradual change with time [1]. All of these effects can produce variations in the slope of the ramp, which critically affects the performance of the overall SS ADC. This is illustrated in Fig. 1.