Adverse effects in kidney function, antioxidant systems and histopathology in rats receiving monosodium glutamate diet

Contini, María del Carmen; Fabro, Ana Patricia; Millen, Néstor; Benmelej, Adriana; Mahieu, Stella

doi:10.1016/j.etp.2017.03.003

Cited by 22 publications

(11 citation statements)

References 35 publications

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“…Previously published work showed that MSGinduced toxicity in renal culture cells (Leung et al, 2008), kidney damage (Sharma, 2015), alteration in glomerular and tubular histology, increase in urea and creatinine, and kidney infiltration of inflammatory cells (Contini et al, 2017). Therefore, our data that point to MSG caused high blood urea and creatinine and kidney tissue damage, and inflammatory cell infiltration are in agreement with the above findings.…”

Section: Discussionsupporting

confidence: 92%

Suppression of Monosodium Glutamate-Induced Acute Kidney Injury and Renal Ultrastructural Damage in Rats by Vitamin E

et al. 2019

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Food additives and flavour enhancers used in the food industry are potential health risks. We tested the hypothesis that the food additive and flavour enhancer, monosodium glutamate (MSG), which is the sodium salt of glutamic acid can induce ultrastructural alterations to the kidney, and the antioxidant vitamin E can protect against acute kidney injuries induced by a toxic dose of MSG in a rat model of the disease. The model group of rats received a daily dose of MSG (4 gm/kg) for 7 days, whereas the protective groups were either received a 100 mg/kg vitamin E plus MSG or 300 mg/kg vitamin E plus MSG for 7 days. Rats were then sacrificed on day 8. Transmission and light microscopy images revealed substantial kidney damage induced by MSG in the model group as demonstrated by degenerated epithelial cells with Pyknotic nuclei, swollen mitochondria, damaged brush margins, dilated tubules, and widening of Bowman's space with shrinkage and deformity of some glomeruli. Treatment of the model group with vitamin E showed a substantial protection of kidney tissue and renal ultrastructure by 300 mg/kg vitamin E compared to a partial protection by 100 mg/kg vitamin E. In addition, MSG significantly (p<0.05) increased serum levels of urea and creatinine, which were significantly (p<0.05) decreased with vitamin E. However, for serum creatinine, high doses of vitamin E (300 mg/kg) were more effective than lower doses (100 mg/kg) of vitamin E. These results indicate that vitamin E at 300 mg/kg effectively protects against MSG-induced acute kidney injury in rats.

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Section: Discussionsupporting

confidence: 92%

Suppression of Monosodium Glutamate-Induced Acute Kidney Injury and Renal Ultrastructural Damage in Rats by Vitamin E

et al. 2019

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“…The effect of either MSG or NaCl added to food and water was also compared: both treatments induced hypertension, while only MSG evoked hyperfiltration followed by sodium, potassium and water reabsorption, with the involvement of NMDA receptors 35 . In this model, no increase in lipid peroxidation was observed, but fibrosis was present 36 . Despite being relevant part of our diet, several studies in the literature refer to the effects of injection of a high dose glutamate in neonatal rodents, which results in increased body weight, fat deposition, decreased motor activity, and secretion of growth hormone in the rat 37 .…”

Section: Discussionmentioning

confidence: 62%

Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice

Celestino

Valdez

Brun

et al. 2021

Sci Rep

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Monosodium Glutamate (MSG) is used as flavour enhancer, with potential beneficial effects due to its nutritional value. Given the decline in kidney functions during aging, we investigated the impact of MSG voluntary intake on the kidney of male mice, aged 6 or 18 months. For 2 months, they freely consumed water (control group), sodium chloride (0.3% NaCl) or MSG (1% MSG) in addition to standard diet. Young animals consuming sodium chloride presented signs of proteinuria, hyperfiltration, enhanced expression and excretion of Aquaporin 2 and initial degenerative reactions suggestive of fibrosis, while MSG-consuming mice were similar to controls. In old mice, aging-related effects including proteinuria and increased renal corpuscle volume were observed in all groups. At an advanced age, MSG caused no adverse effects on the kidney compared to controls, despite the presence of a sodium moiety, similar to sodium chloride. These data show that prolonged MSG intake in mice has less impact on kidney compared to sodium chloride, that already in young animals induced some effects on kidney, possibly related to hypertension.

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“…Khalaf and Arafat, 2015 [22] mentioned that MSG is considered as a leading cause of weight gain as it motivate the oro-sensory receptors, improves the deliciousness of meals and increases the appetite. Contini et al, 2017 [23] observed sodium and water retention in rats fed a diet supplemented with 3gm of MSG/ kgm body weight/day, five days a week for 16 weeks. This might be one of the causes of increase weight gain and increase water intake in MSG treated rats in the current study as compared to control group.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Diet Coke and Monosodium Glutamate on the Cerebellar Cortex of Adult Male Albino Rats. Histological and Immuno-histochemical Study

El-Wahed

Geith

Kalleny

et al. 2019

Egyptian Journal of Histology

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Background: The consumption of fast-food is increasing among children, adolescents and adults. Carbonated drinks as Diet Coke are widely consumed with fast food. One of the thousands of chemicals used in our new high-tech foods is the monosodium glutamate (MSG). Aim of the study: This study was conducted to investigate the effect of Diet Coke and monosodium glutamate salt either separately or in combination on the cerebellar cortex of adult male albino rats. Materials and Methods: Forty adult male albino rats were divided into four groups. Group I: control group. Group II (Diet Coke group) which was subdivided into: subgroup IIA: each rat received 2.5 ml of Diet Coke twice daily by oral gavage and subgroup IIB: rats received Diet Coke instead of water throughout the day. Group III (MSG group): rats received MSG salt solution (3 gm MSG / kgm) by oral gavage once daily. Group IV (combination group) rats received combination of MSG solution and Diet Coke. This group was subdivided into two subgroups. Subgroup IVA: rats received MSG salt solution in the same dose as group III and 2.5 ml of Diet Coke twice daily, by oral gavage. Subgroup IVB: rats received MSG salt solution in the same dose as group III and Diet Coke instead of water throughout the day. At the end of the experiment (21 days) cerebella were dissected out and processed for histological, immunohistochemical and morphometric studies. Results: Histological examination of the cerebellar cortex revealed that both Diet Coke and MSG either separately or in combination resulted in degenerative changes that were more significant in the combination group. Conclusion: Diet Coke and MSG induced degenerative changes in the cerebellar cortex that was more significant in their combination.

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Adverse effects in kidney function, antioxidant systems and histopathology in rats receiving monosodium glutamate diet

Cited by 22 publications

References 35 publications

Suppression of Monosodium Glutamate-Induced Acute Kidney Injury and Renal Ultrastructural Damage in Rats by Vitamin E

Suppression of Monosodium Glutamate-Induced Acute Kidney Injury and Renal Ultrastructural Damage in Rats by Vitamin E

Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice

The Effect of Diet Coke and Monosodium Glutamate on the Cerebellar Cortex of Adult Male Albino Rats. Histological and Immuno-histochemical Study

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