Background The consumption of fast- food is increasing among children, adolescents and adults. Carbonated drinks are widely consumed with fast food that also exists in the form of diet drinks as Diet Coke. One of the thousands of chemicals used in our new high-tech foods is the monosodium glutamate (MSG). Aim of the Study This study was conducted to investigate the effect of Diet Coke and monosodium glutamate salt either separately or in combination on the cerebellar cortex and kidney of adult male albino rats. Materials and Methods Twenty five adult male albino rats were divided into four groups. Group I: control group (10 rats) divided equally into two subgroups, subgroup IA in which rats had free access to food and water and subgroup 1B in which each rat administrated 0.5 ml of distilled water once daily by oral gavage. Rats had free access to food and water. Group II (5 rats): in which rats received Diet Coke instead of water throughout the day. Group DI (5 rats): in which each rat received 0.5m1 of MSG salt solution by dose of 3ern MSG/kgm by oral gavage once daily. Group IV (5 rats): in which each rat received Diet Coke instead of water throughout the day and 0.5m1 of MSG salt solution by dose of 3gm MSG/kgm by oral gavage once daily. Cerebella and kidneys were dissected out and processed for histological, immunohistochemical and morphometric studies. Results Histological examination of the cerebellum and the kidney revealed that both Diet Coke and MSG either separately or in combination resulted in degenerative changes that were more significant in the combination group. The cerebellum showed degeneration of Purkinje cells and vaculations in the molecular layer. The kidney showed shrunken glomeruli, vacuolations of cells lining renal tubules with pyknotic nuclei. Hyaline debris detected in renal sections of combination group. Conclusion Diet Coke and MSG induced degenerative changes in both the cerebellum and the kidney that was more significant in their combination.
Background: The consumption of fast-food is increasing among children, adolescents and adults. Carbonated drinks as Diet Coke are widely consumed with fast food. One of the thousands of chemicals used in our new high-tech foods is the monosodium glutamate (MSG). Aim of the study: This study was conducted to investigate the effect of Diet Coke and monosodium glutamate salt either separately or in combination on the cerebellar cortex of adult male albino rats. Materials and Methods: Forty adult male albino rats were divided into four groups. Group I: control group. Group II (Diet Coke group) which was subdivided into: subgroup IIA: each rat received 2.5 ml of Diet Coke twice daily by oral gavage and subgroup IIB: rats received Diet Coke instead of water throughout the day. Group III (MSG group): rats received MSG salt solution (3 gm MSG / kgm) by oral gavage once daily. Group IV (combination group) rats received combination of MSG solution and Diet Coke. This group was subdivided into two subgroups. Subgroup IVA: rats received MSG salt solution in the same dose as group III and 2.5 ml of Diet Coke twice daily, by oral gavage. Subgroup IVB: rats received MSG salt solution in the same dose as group III and Diet Coke instead of water throughout the day. At the end of the experiment (21 days) cerebella were dissected out and processed for histological, immunohistochemical and morphometric studies. Results: Histological examination of the cerebellar cortex revealed that both Diet Coke and MSG either separately or in combination resulted in degenerative changes that were more significant in the combination group. Conclusion: Diet Coke and MSG induced degenerative changes in the cerebellar cortex that was more significant in their combination.
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