Adaptation Effect of Repeated Xenon Application

Stryapko, N. V.; Сазонтова, Т. Г.; Potievskaya, V.I.; Khairullina, A. A.; Vdovina, I. B.; Kulikov, A. N.; Arkhipenko, Y.-U. V.; Molchanov, I. V.

doi:10.15360/1813-9779-2014-2-50-56

Cited by 6 publications

(2 citation statements)

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“…Thus, it remains unclear whether Xe inhalation enhanced anxiety-like behavior in VPA-exposed rats. Moreover, some authors propose potential effectiveness of Xe inhalations in treatment of anxiety disorders [32, 64]. Still, further studies broadening an understanding of anxiety-like behavior after Xe inhalation in VPA model of ASD’ may be warranted.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of xenon inhalation on behavioral changes in a valproic acid-induced model of autism in rats

et al. 2019

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BackgroundXenon (Xe) is a noble gas that has been used for the last several decades as an anesthetic during surgery. Its antagonistic effect on glutamate subtype of NMDA (N-methyl-d-aspartate) receptors resulted in evaluation of this gas for treatment of CNS pathologies, including psychoemotional disorders. The aim of this study was to assess the behavioral effects of acute inhalation of subanesthetic concentrations of Xe and to study the outcomes of Xe exposure in valproic acid (VPA)-induced rodent model of autism.MethodsWe have conducted two series of experiments with a battery of behavioral tests aimed to evaluate locomotion, anxiety- and depression-like behavior, and social behavior in healthy, VPA-treated and Xe-exposed young rats.ResultsWe have shown that in healthy animals Xe exposure resulted in acute and delayed decrease of exploratory motivation, partial decrease in risk-taking and depressive-like behavior as well as improved sensorimotor integration during the negative geotaxis test. Acute inhalations of Xe in VPA-exposed animals led to improvement in social behavior, decrease in exploratory motivation, and normalization of behavior in forced-swim test.ConclusionBehavioral modulatory effects of Xe are probably related to its generalized action on excitatory/inhibitory balance within the CNS. Our data suggest that subanesthetic short-term exposures to Xe have beneficial effect on several behavioral modalities and deserves further investigation.

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Section: Discussionmentioning

confidence: 99%

Beneficial effects of xenon inhalation on behavioral changes in a valproic acid-induced model of autism in rats

et al. 2019

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“…Therefore, it is expectable the impact of xenon on the vital organs, including the CNS. Now xenon is used in the form of inhalations, which results in decrease in fatigue, improve sleep, prevent the development of stress, and improve the adaptability of the organism [12]. Using our own technology of xenon dissolving in a variety of liquid funds and products, and with questionnaire test, we decided to see how overall psychophysiological profile of adult men may change after daily drinking water with xenon.…”

Section: Introductionmentioning

confidence: 99%

Manufacturing the Technology of Xenon-Containing Drinking Water and its Influence on Some Psychophysiological Characteristics of Man

2016

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Abstract. This study is aimed to describe the technology of making xenoncontaining drinking water and its impact on health and psychophysiological characteristics of 26 volunteers after regular admission. Testing conducted after 2 months of daily use such water showed significant improvement of emotional state and health of volunteers. This technology allows obtaining a large amount of drinking water saturated with xenon, which can be used in therapeutic and prophylactic purposes.

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