Beneficial effects of xenon inhalation on behavioral changes in a valproic acid-induced model of autism in rats

Dobrovolsky, Alexander; Gedzun, V.; Bogin, Vladimir; Ma, Daqing; Ichim, Thomas E.; Sukhanova, I.; Малышев, А. В.; Дубынин, В. А.

doi:10.1186/s12967-019-02161-6

Cited by 5 publications

(2 citation statements)

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“…Nevertheless, this deficit was diminished by the end of weaning, i.e., PND 21 ( Figure 4 ). The motor coordination delay was observed in other Shank3 mutant strain ( Shank3 Δ4–22 ) as well as in other models of ASD [ 22 , 33 , 34 , 35 ]. The delay in acquisition of postural reflexes could be an important early indicator of motor impairment in this model.…”

Section: Discussionmentioning

confidence: 77%

Neuromotor Development in the Shank3 Mouse Model of Autism Spectrum Disorder

et al. 2022

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Although autism spectrum disorder (ASD) is mainly characterized by developmental delay in social and communication skills, it has been shown that neuromotor deficits are an early component of ASD. The neuromotor development of B6.129-Shank3tm2Gfng/J (Shank3B-/-) mice as an animal model of autism has not been analyzed yet. The aim of this study was to compare the early neuromotor development of Shank3B-/- to wild-type mice. The mice underwent a multitude of neurodevelopmental tests and observations from postnatal day 1 (PND = 1) to weaning. Shank3B-/- mice opened their eyes later than their wild-type litter mates (p < 0.01). Shank3B-/- mice were also slower in the negative geotaxis test from PND = 13 to PND = 16 (p < 0.001) in both sexes. The results of this study indicate neurodevelopmental deficits in Shank3B-/- mice. The test is partially dependent on truncal motor control, and these lines of evidence suggest a phenotype of developmental hypotonia, which corresponds with the phenotypes seen in patients with Phelan-McDermid Syndrome. There was no observable effect of sex in any of the tests. There were no observed differences in upper and lower incisor eruption, ear unfolding, air righting, surface righting and ear twitch reflexes. Further studies should prove whether the delay in neuromotor development is linked to social or communication deficits, and thus, whether it may serve as an early indicator of autistic-like phenotype in mice.

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Section: Discussionmentioning

confidence: 77%

Neuromotor Development in the Shank3 Mouse Model of Autism Spectrum Disorder

et al. 2022

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“…The social novelty test was performed to study the social preference between familiar and unfamiliar rats in T-maze. The test was performed with a dam and an unfamiliar non-lactating female on PND 22, and with a sibling rat and non-sibling rat on PND 33, in red light (4 lux), according to the protocol described in Dobrovolsky et al (2019) . The T-maze ( Figure 1C ) had 35 cm high opaque walls, 10 cm × 26 cm starting compartment, and 10 cm × 50 cm two side compartments.…”

Section: Methodsmentioning

confidence: 99%

The Behavior and Postnatal Development in Infant and Juvenile Rats After Ultrasound-Induced Chronic Prenatal Stress

et al. 2021

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Fetal development is susceptible to environmental factors. One such factor is exposure to stress during pregnancy. The present study aimed to investigate the effects of chronic prenatal stress (PS) on the development and behavior of rat offspring during infancy and juvenile ages. Existing approaches to modeling prenatal stress on animals do not correlate with the main type of stress in pregnant women, namely psychological stress. We used a new stress paradigm in the experiment, namely, stress induced by exposure to variable frequency ultrasound (US), which acted on pregnant Wistar rats on gestational days 1–21. This type of stress in rodents can be comparable to psychological stress in humans. We assessed physical development, reflex maturation, motor ability development, anxious behavior, response to social novelty, and social play behavior in male and female offspring. Additionally, we investigated maternal behavior and the effect of neonatal handling (NH) on behavior. Prenatal stress did not affect postnatal developmental characteristics in rat pups, but prenatally stressed rats had higher body weight in early and adult age than controls. Prenatal exposure to a stressor increased anxiety in the open-field test (OF), changed social preferences in the social novelty test (SN), and impaired social play behavior in males. Neonatal handling reduced anxiety and restored social behavior, but evoked hyperactive behavior in rat pups. Maternal behavior did not change. Our study demonstrated for the first time that exposure to variable frequency ultrasound during pregnancy influences offspring development and impairs behavior, correlating with the effects of other types of stress during pregnancy in rodents. This supports the idea of using this exposure to model prenatal stress.

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