Aim: The purpose of the study was to characterize transdermal delivery of xenon through rat skin from a lipophilic solution and from water. Methods: Sections of skin were obtained from adult rats (n=12) and were placed into static Franz diffusion cells for 24 h. Xenon diffusion coefficients were determined for diffusion from a lipophilic solution (n=6) and from water (n=6) to phosphate buffered saline (PBS) through skin and for diffusion from a lipophilic solution to PBS through a phase boundary in the absence of skin (n=6). Results: Xenon flux (J Xe ) through skin from the lipophilic solution was 0.036 mg/hour×cm 2 and permeability coefficient (K p ) was 0.003 cm/h; J Xe through skin from water was 0.029 mg/h×cm 2 and the K p was 0.002 cm/h. Total time for xenon diffusion through skin from lipophilic solution and from water was ~2 h. Conclusion: The study presents the first characterization of xenon diffusion through rat skin from multiphase solutions to PBS. These data may be useful for the development of xenon-rich pharmaceutical products for external use.
Xenon is confirmed to diffuse readily through membranes and has properties of transdermal enhancer. In this study, the ability of xenon to regulate the transdermal diffusion of niacinamide was investigated using a model of an artificial skin analogue of Strat-M™ membranes in Franz cells. Based on the data obtained, we found that in the simplified biophysical model of Strat-M™ membranes xenon exerts its enhancer effect based on the heterogeneous nucleation of xenon at the interfaces in the microporous structures of Strat-M™ membranes.
Abstract. This study is aimed to describe the technology of making xenoncontaining drinking water and its impact on health and psychophysiological characteristics of 26 volunteers after regular admission. Testing conducted after 2 months of daily use such water showed significant improvement of emotional state and health of volunteers. This technology allows obtaining a large amount of drinking water saturated with xenon, which can be used in therapeutic and prophylactic purposes.
Abstract.We have developed an agent for external use to deliver xenon into the skin. Using the model of skin wound we have studied the effect of xenon on the process of wound healing in rats. It has been shown that the application of xenon-containing cream on wound surface significantly accelerates the healing process as compared to control animals where cream without xenon has been applied.
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