Xenon as a transdermal enhancer for niacinamide in Strat-M™ membranes

Abstract

Xenon is confirmed to diffuse readily through membranes and has properties of transdermal enhancer. In this study, the ability of xenon to regulate the transdermal diffusion of niacinamide was investigated using a model of an artificial skin analogue of Strat-M™ membranes in Franz cells. Based on the data obtained, we found that in the simplified biophysical model of Strat-M™ membranes xenon exerts its enhancer effect based on the heterogeneous nucleation of xenon at the interfaces in the microporous structures of Strat-M™ membranes.

Injury Site Specific Xenon Delivered by Platelet Membrane‐Mimicking Hybrid Microbubbles to Protect Against Acute Kidney Injury via Inhibition of Cellular Senescence

“…All microbubble samples were diluted to the same concentration (1 × 10 5 mL −1 ) with PBS, and then 1 mL of the microbubble solution was added to the sample well of a 2% (w/v) agarose mold, as described in a previous study. [28,29] In vitro ultrasound imaging was performed using a preclinical Vevo 3100 micro-ultrasound system (Visu-alSonics, Canada) with an MX250 high-frequency probe in the nonlinear contrast mode. The imaging parameters were: frequency, 18 MHz; power, 10%; imaging depth, 25 mm; and acoustic focus at the center of the sample well.…”