We studied the effect of cannabinoid receptor agonists anandamide and WIN 55,212-2 on the central pain syndrome induced by intraspinal injection of penicillin sodium salt in rats. Cannabinoids suppressed allodynia and spontaneous attacks in rats with the central pain syndrome. The analgesic effect was most pronounced after intrathecal injection of cannabinoid receptor agonist in a dose of 100 microg in 10 microl. After systemic treatment the analgesic effect was produced by only WIN 55,212-2 in a dose of 1 mg/kg. WIN 55,212-2 was superior to anandamide by the duration and intensity of the effect on allodynia and spontaneous attacks.

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K A. Evseev, L. A. Basharova, et aL 819 0.29 mg/dl in the control (n=5, p<0.01). It is known that synthesis of the acute phase proteins in the liver is induced by the products of activated phagocytes [9].These results suggest that the previously described NK-induced changes in the blood system are associated not only with the stress-realizing systems but also with activation of phagocytizing cells. Eur. J. Cancer., 26, No. 5, 641-644 (1990). 9. H. Baumann and J. Gauldie, lmmunol. Today, 15, No. 2, 74-80 (1994). 10. M. A. Jagels and T. E. Hugli, J. ImmunoL, 148, No. 4, 1119148, No. 4, -1129148, No. 4, (1992. 11. A. Marusic, I. Djikic, and M. Marusic, Agents Actions, 31, No. 3-4, 280-284 (1990). Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 8, pp. 189-192, August, 1996 Original article submitted April 12, 1995 REFERENCES Immunotherapy of Experimental DrugSystemic administration of antiserotonin and antidopamine antibodies to chronically morphinized animals reduces the major manifestations of the withdrawal syndrome induced by naloxone injection or discontinuation of morphine.

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