Acute and sub-chronic toxicity of a lyophilised aqueous extract of Centaurium erythraea in rodents

Tahraoui, Adel; Israili, Zafar H.; Lyoussi, Badiaâ

doi:10.1016/j.jep.2010.07.038

Cited by 52 publications

(27 citation statements)

References 46 publications

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“…Rats were selected according to sex in cages each carries five animals. Acute toxicity was estimated using the method described by Tahraoui and colleagues 7 animals were divided in 05 groups of 10 animals (05 males and 05 females). Then, they received single doses of 0.4, 0.6, 0.8 and 1 ml / kg of the EO of P. alba and from 1, 3, 5 and 7 ml / kg of the EO of R. officinalis and 9 ‰ NaCl (control) by intraperitoneal injection.…”

Section: Acute Toxicity Testmentioning

confidence: 99%

Radiographic and Histopathologic Analysis on Osteoarthritis Rat Model Treated with Essential Oils of Rosmarinus officinalis and Populus alba

Belkhodja¹,

Meddah²,

Tirtouil³

et al. 2017

Pharm Sci

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Section: Acute Toxicity Testmentioning

confidence: 99%

Radiographic and Histopathologic Analysis on Osteoarthritis Rat Model Treated with Essential Oils of Rosmarinus officinalis and Populus alba

Belkhodja¹,

Meddah²,

Tirtouil³

et al. 2017

Pharm Sci

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“…The renal function was assessed by measuring the concentrations of urea and plasma creatinine (Baliga et al, 2004;Tahraoui et al, 2010;Harizal et al, 2010;Atsamo et al, 2011). Concerning the biochemical data, all blood biochemical parameters examined in this study were in physiological limits as reported by Quinton (2003).…”

Section: Sub-chronic Oral Toxicity Of the Vegetable Oil Of Pistacia Lmentioning

confidence: 72%

“…Despite the popular use of the vegetable oil of Pistacia lentiscus L., systematic assessment of toxic effects is almost absent, information of toxicity of this plant is very important as a reference point before exploring to continue to develop it as new herbal medicine (Tahraoui et al, 2010;Harizal et al, 2010). The aim of the present study is the investigation of some physico-chemical parameters of this oil and the evaluation to its sub-chronic oral toxicity in rabbits.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Characteristics and Sub Chronic Oral Toxicity of <i>Pistacia lentiscus</i> L. Vegetable Oil in Rabbits

Maameri¹,

Djerrou²,

Habibatni³

et al. 2016

OnLine Journal of Biological Sciences

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Pistacia lentiscus vegetable oil is a well known natural product in Algerian traditional medicine. It is widely used in the treatment of back pain, respiratory problems and skin burns. The aim of this study was the determination of some physicochemical parameters and the investigation of sub-chronic oral toxicity of this fatty oil in rabbits. The physico-chemical parameters obtained for this oil were similar to those reported for similar oils [density: 0.915, refractive index: 1.46; acid value (mg KOH/g): 8.4; saponification value (mg KOH/g): 187.5]. The sub-chronic toxicity test conducted in rabbits at different doses (0.5, 1 and 2 mL kg −1 ) for 28 days via oral route did not result in any signs of toxicity. The biochemicals results indicate that this oil maintain rates of ALT and AST in the physiological norms. A significant decrease in blood glucose was registered, but always within the physiological standards. Other experimental studies are required to accomplish the pharmacotoxicological profile of this vegetable oil which is in spreading use.

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“…The aforementioned organ samples were fixed in 10% formalin for 36 h at 25˚C, embedded in paraffin, sliced into sections 5-µm thick, stained with haematoxylin for 5-10 min and then stained with eosin for 1-3 min at 25˚C. Samples were observed using an optical microscope (24,25).…”

Section: Systematic Anatomymentioning

confidence: 99%

Evaluation of the acute and chronic toxicity of the jiangu capsules

et al. 2017

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Abstract. Saussureae involucratae Flos is the primary component of the jiangu capsule, which also consists of 12 types of natural medicine. It is a traditional Chinese medicine used to treat a number of conditions including arthralgia, cold and sore muscles, stiff limbs, inconvenient flexion and activity limitation caused by different types of osteoarthritis. The present study was performed to assess the safety of the jiangu capsule following acute and chronic administration in mice and rats. In the acute study, mice were treated with the jiangu capsule orally at 16 g/kg/day, the highest dose, for 14 days. In the chronic oral toxicity study, rats were treated with 2, 4 and 8 g/kg/day of the jiangu capsule for 6 months. The general condition, body weight changes, food and water consumption, hematological and biochemical parameters, urinalysis, systematic anatomy and organ weights of the rats were monitored and histopathological examination was performed at the end of 3 and 6 months' daily administration, and following 14 days of withdrawal. There were no signs of toxicity in the general condition and body weight of the mice was not significantly affected by the treatment. Furthermore, necropsy findings for the animals in the acute and chronic toxicity studies demonstrated that no mortalities had occurred. The results of the current study indicate that treatment with the jiangu capsule did not induce mortality or any detectable abnormalities in mice and rats.

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Acute and sub-chronic toxicity of a lyophilised aqueous extract of Centaurium erythraea in rodents

Cited by 52 publications

References 46 publications

Radiographic and Histopathologic Analysis on Osteoarthritis Rat Model Treated with Essential Oils of Rosmarinus officinalis and Populus alba

Radiographic and Histopathologic Analysis on Osteoarthritis Rat Model Treated with Essential Oils of Rosmarinus officinalis and Populus alba

Physicochemical Characteristics and Sub Chronic Oral Toxicity of <i>Pistacia lentiscus</i> L. Vegetable Oil in Rabbits

Evaluation of the acute and chronic toxicity of the jiangu capsules

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