Physicochemical Characteristics and Sub Chronic Oral Toxicity of <i>Pistacia lentiscus</i> L. Vegetable Oil in Rabbits

Abstract

Pistacia lentiscus vegetable oil is a well known natural product in Algerian traditional medicine. It is widely used in the treatment of back pain, respiratory problems and skin burns. The aim of this study was the determination of some physicochemical parameters and the investigation of sub-chronic oral toxicity of this fatty oil in rabbits. The physico-chemical parameters obtained for this oil were similar to those reported for similar oils [density: 0.915, refractive index: 1.46; acid value (mg KOH/g): 8.4; saponification value (mg KOH/g): 187.5]. The sub-chronic toxicity test conducted in rabbits at different doses (0.5, 1 and 2 mL kg −1 ) for 28 days via oral route did not result in any signs of toxicity. The biochemicals results indicate that this oil maintain rates of ALT and AST in the physiological norms. A significant decrease in blood glucose was registered, but always within the physiological standards. Other experimental studies are required to accomplish the pharmacotoxicological profile of this vegetable oil which is in spreading use.

Phytochemical profile of Tunisian Pistacia lentiscus fruits oil: Antioxidant, antiplatelet, and cytotoxic activities assessment

“…These findings are promising for the therapeutic application of PLFO in preventing cardiovascular diseases. [73] This can be confirmed by the PUFA/SAFA ratio which was worth 0.68, higher than 0.50, and (PUFA+MUFA)/SAFA ratio which was higher than 1.8 (Table 4). Both cut-off points were associated with a low risk of cardiovascular diseases.…”

Essential Oil Plants Traditionally Used in Wound Treatment: Systematic Review

“…are utilized for their pharmacological effects, including the reduction of blood pressure, anti-inflammatory, antimicrobial, hypoglycemic, wound healing, and analgesic properties. [67][68][69] In this study, two different ointments were prepared using essential oils from Algerian and Italian Pistacia species, which were mixed with petroleum jelly to create Essential Oil Algerian and Italian Ointments formulations [EOAO (5%) and EOIO (5%)]. These ointments were applied to New Zealand albino male rabbits with eye and acute dermal irritations for a duration of 16 days.…”