A Review on Phytochemical Constituents and Pharmacological Activities of Ricinus communis L. Plant

Kumar, Manish

doi:10.25258/phyto.v9i4.8116

Cited by 30 publications

(26 citation statements)

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“…According to reported literature [ 51 , 52 , 53 , 54 ], the roots and leaves of Ricinus communis contained various phenolic and flavonoid compounds such as n -haxadecanoic acid, octadecanoic acid, 1-hexadecanol. 2-methyl, l-valine, triethyl citrate, diethyl phthalate, gallic acid, kaempferol-3- o -b- d -xylopyranoside, kaempferol-3- o -b- d -xylopyranoside, and quercetin-3-0- p - d -glucopyranoside; however, the major consistent of root extract is Indole-3-acetic acid.…”

Section: Resultsmentioning

confidence: 99%

Green Synthesis, Characterization, Enzyme Inhibition, Antimicrobial Potential, and Cytotoxic Activity of Plant Mediated Silver Nanoparticle Using Ricinus communis Leaf and Root Extracts

et al. 2021

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The need of non-toxic synthesis protocols for nanoparticles arises developing interest in biogenic approaches. The present project was focused on cost effective, environment congenial synthesis of Ag nanoparticles and their biological applications. Leaf and root extracts of Ricinus communis were used as a reducing and stabilizing agent in synthesis process. A Proposed mechanism in published literature suggested that Indole-3-acetic acid, l-valine, triethyl citrate, and quercetin-3-0-p-d-glucopyranoside phytoconstituents of Ricinus communis act as reducing and capping agents. The synthesized Ag NPs were characterized with a help X-ray diffractometer, Transmission electron microscopy, UV-Vis spectrophotometry and Fourier Transform Infrared Spectroscopy (FTIR). The XRD results inveterate the synthesis of pure nano size crystalline silver particles. The FTIR data revealed the possible functional groups of biomolecules involved in bio reduction and capping for efficient stabilization of silver nanoparticles. TEM analysis confirmed the almost spherical morphology of synthesized particles with mean size 29 and 38 nm for R-Ag-NPs (root) and L-Ag-NPs (leaf), respectively. The stability of synthesized nanoparticles was examined against heat and pH. It was observed that synthesized nanoparticles were stable up to 100 °C temperature and also showed stability in neutral, basic and slightly acidic medium (pH 05–06) for several months while below pH 5 were unstable. The synthesized silver nanoparticles had promising inhibition efficiency in multiple applications, including as bactericidal/fungicidal agents and Urease/Xanthine oxidase enzymes inhibitors. The cytotoxicity of synthesized nanoparticles shows that the concentration under 20 μg/mL were biologically compatible.

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Section: Resultsmentioning

confidence: 99%

Green Synthesis, Characterization, Enzyme Inhibition, Antimicrobial Potential, and Cytotoxic Activity of Plant Mediated Silver Nanoparticle Using Ricinus communis Leaf and Root Extracts

et al. 2021

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“…Ricinus communis is a traditional medicinal plant, and its leaves and seeds were reported to have pharmacological effects, such as anti-inflammatory, immunomodulator, antidiabetic, antiulcer, etc. (Kumar. 2017).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial activity of polyisoprenoids of sixteen mangrove species from North Sumatra, Indonesia

Sumardi¹,

Basyuni

Wati

2018

Biodiversitas

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Sumardi, Basyuni M, Wati R. 2018. Antimicrobial activity of polyisoprenoids of sixteen mangrove species from North Sumatra, Indonesia. Biodiversitas 19: 1243-1248. Mangroves including those that are distributed in the coast of North Sumatra containpolyisoprenoid with varying levels of polyprenol and dolichol constituents. Differences in polyisoprenoid levels were closely related tothe salinity of sea but the information about their biological activities is scarce. The present study aimed to describe the biologicalactivities, antimicrobial, antioxidant, and antifungal effects of polyisoprenoid extracts from sixteen mangrove species of North Sumatra,Indonesia. Polyisoprenoids were isolated from mangrove leaves and tested for their antimicrobial activity against Escherichia coli,Staphylococcus aureus, and Candida albicans. Meanwhile, their antioxidant activity was represented by their capacity in scavengingDPPH (2,2-diphenyl-1-picrylhydrazyl) free-radical agents. The most predominant polyisoprenoids found in sixteen mangrove leafextracts was dolichols (75%). Polyprenols-dominant species, Acacia auriculiformis, Hibiscus tiliaceus, Pongamia pinnata, and Ricinuscommunis, and dolichols-dominant species, Avicennia lanata, Av. marina, Av. officinalis, Barringtonia asiatica, Bruguieragymnorrhiza, Calophyllum inophyllum, Nypa fruticans, and Pandanus odoratissimus, inhibited the growth of E. coli and S. aureus.However, the antioxidant activity of those sixteen mangrove species was of a weak category. Surprisingly, all other mangrovespolyisoprenoid extracts did not inhibit C. albicans growth. This study suggested that polyisoprenoids in mangroves have potentialantibacterial properties to be developed further.

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“…Administration of ethanol R. communis extract was able to reverse this condition in diabetic rats, thereby lowering the bilirubin level to normalcy. We explained this with the fact that extracts containing glucosides might be converted to glucorunic acid for conjugating with bilirubin for excretion (Afrisham et al, 2015; Kumar, 2017). Also, the extract can activate the Constitutive Andostane Receptor (CAR) in order to facilitate the bilirubin clearance pathway (Arthur et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Potential antidiabetic effect of ethanolic and aqueous-ethanolic extracts ofRicinus communisleaves on streptozotocin-induced diabetes in rats

Gad‐Elkareem

Abdelgadir

Badawy

et al. 2019

PeerJ

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Recently, herbal drugs and their bioactive compounds have gained popularity in the management of diabetes mellitus (DM), which has become an epidemic disease all over the world and is especially prevalent in the Kingdom of Saudi Arabia (KSA). This study aimed to investigate the antidiabetic effect of ethanolic and aqueous-ethanolic extracts of wild Ricinus communis (R. communis) leaves in streptozotocin (STZ) induced diabetic rats. Diabetic rats were administered orally with the mentioned extracts at doses of 300 and 600 mg/kg/BW for 14 days, and the obtained results of different biochemical parameters were compared with normal control, diabetic control and standard drug glibenclamide (5 mg/kg/BW). The obtained results revealed a remarkable and significantly (P < 0.05) reverse effect of the body weight loss, observed when diabetic rats were treated with ethanol and aqueous-ethanol extracts at 300 mg/kg/BW. Administration of the ethanol extract at 600 mg/kg/BW significantly (P < 0.05) reduced the blood glucose level. A significant increase in the AST, ALT and ALP levels (P < 0.05) was observed in the diabetic control and in the experimental groups with glibenclamide which was also significantly (P < 0.05) lowered after treatment with extracts at special doses. Total proteins, albumin, total bilirubin, direct bilirubin, creatinine and urea were also investigated and compared to the corresponding controls. We showed that administration of R. communis extract generally significantly (P < 0.05) ameliorated the biochemical parameters of diabetic rats. Also, the changes in serum electrolyte profile were assessed and the results demonstrate that administration of extracts at concentration of 600 mg/kg/BW generally inhibits the alteration maintain their levels. The obtained data imply the hypoglycemic effects of this plant, which may be used as a good alternative for managing DM and therefore validating its traditional usage in KSA.

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A Review on Phytochemical Constituents and Pharmacological Activities of Ricinus communis L. Plant

Cited by 30 publications

References 0 publications

Green Synthesis, Characterization, Enzyme Inhibition, Antimicrobial Potential, and Cytotoxic Activity of Plant Mediated Silver Nanoparticle Using Ricinus communis Leaf and Root Extracts

Green Synthesis, Characterization, Enzyme Inhibition, Antimicrobial Potential, and Cytotoxic Activity of Plant Mediated Silver Nanoparticle Using Ricinus communis Leaf and Root Extracts

Antimicrobial activity of polyisoprenoids of sixteen mangrove species from North Sumatra, Indonesia

Potential antidiabetic effect of ethanolic and aqueous-ethanolic extracts ofRicinus communisleaves on streptozotocin-induced diabetes in rats

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