Antimicrobial activity of polyisoprenoids of sixteen mangrove species from North Sumatra, Indonesia

Sumardi, Sumardi; Basyuni, Mohammad; Wati, Ridha

doi:10.13057/biodiv/d190409

Cited by 25 publications

(15 citation statements)

References 24 publications

(39 reference statements)

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“…In line with this finding, the polyprenols in the root tissues were also dominated by dolichols [5], [7]. Polyisoprenoids have been tested in vitro to be more suitable as an antimicrobial agent and an oxidant in associated mangrove leaves and roots [20], consisting mostly of dolichols. Therefore, these results supported the previous view that polyisoprenoid composition in mangroves was not polyprenols but dolichols.…”

Section: Discussionsupporting

confidence: 56%

Prominent Secondary Metabolites from Selected Genus of Avicennia Leaves

Basyuni¹,

Illian²,

Istiqomah³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Mangrove plants distributed in the intertidal of the tropical and subtropical region including in North Sumatra, Indonesia. The production of secondary metabolite compounds is well known to mangroves. Characterisation of prominent compounds from mangrove plants such as genus of Avicennia is required to explore for their biological and pharmacological properties of these compounds. AIM: The purpose of this research was to analyse the prominent secondary metabolites through the characterisation of phytochemical, physicochemical, and microscopic of the mangrove genus Avicennia leaves, particularly Avicennia alba, A. lanata, A. marina, and A. officinalis. METHODS: Phytochemical screening was carried out on Avicennia spp leaves to the established process. Physicochemical characters of mangrove leaves were investigated by simplicial powder consisting of moisture content, water-soluble, ethanol-soluble, ash content and ash soluble acid according to the WHO formula. Microscopic analysis on the simplicial powder was carried out based on the WHO procedure. RESULTS: The result showed that physicochemical feature displays diversity among the species and important findings on the water concentration was less than 10% as a prerequisite for the drug. The phytochemical search of simplified grain also depicted divergence among the species, only alkaloid, saponin, and triterpenoid or phytosterol were found entirely in Avicennia spp leaves. Microscopic search found a similar type of stoma in Avicennia spp leaves, namely diacytic. CONCLUSION: The prominent secondary metabolites in Avicennia spp leaves consisting of alkaloid and saponin in simplicial and triterpenoid/sterol was either in simplicial or hexane extract. The present study may provide significant pharmacological properties from mangrove Avicennia genus green foliages, which could accelerate another prospect for non-wood mangrove utilisation. nus green foliages, which could accelerate another prospect for non-wood mangrove utilization.

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Section: Discussionsupporting

confidence: 56%

Prominent Secondary Metabolites from Selected Genus of Avicennia Leaves

Basyuni¹,

Illian²,

Istiqomah³

et al. 2019

Open Access Maced J Med Sci

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“…The presence of dolichol in all plant tissues (leaf, root, and flower) implied that polyprenol might not play an essential role in mangroves, although the function of polyprenol in the plant world was not well understood (Basyuni et al, 2017a). Recently, polyisoprenoid from sixteen mangrove species showed strong antimicrobial activity but did not inhibit the antifungal activity of Candida albicans (Sumardi et al 2018). More recently, polyisoprenoid from A. marina, A. lanata, and N. fruticans leaves exhibited an anticancer activity of colon cells (Sari et al 2018;Illian et al 2018).…”

Section: The Occurrence and Distribution Of Polyprenols And Dolicholsmentioning

confidence: 99%

Salinity and subsequent freshwater influences on the growth, biomass, and polyisoprenoids distribution of Rhizophora apiculata seedlings

et al. 2018

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Basyuni M, Wasilah M, Hasibuan PAZ, Sulistiyono N, Sumardi, Bimantara Y, Hayati R, Sagami H, Oku H. 2019. Salinity and subsequent freshwater influences on the growth, biomass, and polyisoprenoids distribution of Rhizophora apiculata seedlings. Biodiversitas 20: 288-295. This study described the growth, biomass, and polyisoprenoids (polyprenol and dolichol) distribution of Rhizophora apiculata seedlings under saline and subsequent fresh water treatment. Propagules of R. apiculata were collected from Pulau Sembilan, Langkat, North Sumatra and were grown in 0.0%, 0.5%, 1.5%, 2.0%, and 3.0% salt concentrations for three months. After three months planted in a glass house, R. apiculata seedlings were divided into two groups and grown for another three months. The first group was continuously grown under the saline condition and the second was moved to fresh water to recover from the saline condition. The leaves, stems, and roots of R. apiculata seedlings were harvested after six months of cultivation. Polyisoprenoids alcohol was isolated from the leaves and roots of R. apiculata seedlings and analyzed using two-dimensional thin layer chromatography. Growth parameters measured were height and diameter of R. apiculata seedlings. The height of R. apiculata seedlings was significantly affected by salinity levels of 2.0%, 3.0% and 3.0% → 0.0%. The arrow (→) denoted fresh water recovery treatment. The best height and diameter of R. apiculata seedlings were observed in 0.5% salt concentration. Salinity treatment and re-adaptation into freshwater significantly influenced the leaves area (2.0%, 3.0% and 3.0% → 0.0%), fresh weight of stem (3.0% and 3% → 0.0%) and stem dry weight (3% → 0.0%). Distribution of polyprenols and dolichols in the leaves and roots of R. apiculata seedlings were categorized as type I, where dolichol was dominant over polyprenol. Under salinity and subsequent fresh water recovery treatments (0.0%, 1.5%, 1.5% → 0.0%, 3.0%, and 3.0% → 0.0%), the carbon chain length of dolichol in the leaves and in the roots was, respectively, C85-C100, C85-C100, C85-C105, C85-C100, C85-C95 and C85-C105, C85-C105, C85-C105, C85-C110, C85-C100. These data suggested the significant role of polyisoprenoids in mangrove plants to withstand salt stress and or water stress.

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“…[24,25] Seasonal variations in protein, polyphenol and tannin concentration in leaves of Rhizophoraceae was reported and the organic constituents proteins, polyphenol and tannin concentration were generally highest in rainy seasons, intermediate in summer and lowest in winter of mangrove leaves. [26] Earlier studies indicated that anti bacterial activity of the leaves of Ceriops tagal showed 9.78±0.32 mm zone of inhibition against Bacillus cereus and 9.25 ±0.84 mm against Staphylococcus aureus [27,28] . Bruguiera cylindica showed zone of inhibition of 6.8 ±0.84mm against Pseudomonas aeruginosa.…”

Section: Discussionmentioning

confidence: 99%

Seasonal and Geographical Variations in Antimicrobial Activity of Selected Mangroves from Krishna Estuary

Kovvada¹,

Rosaiah²,

Kakumanu³

et al. 2019

IJCRR

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Objective:To determine the seasonal and geographical impact on plant secondary metabolite production and antimicrobial activity.Methods: Three mangrove plants viz., Ceriops tagal, Bruguiera cylindrica and Lumnitzera racemosa commonly found in Gilakaladindi and Malakayalanka regions of Krishna Estuary, Andhra Pradesh, India were selected for the present study. The study was done during 2014-15 summer, rainy and winter in both the stations. Leaf samples were extracted with methanol and subjected to preliminary phytochemical screening. The methanolic leaf extracts were tested against bacterial pathogens Bacillus cereus, B. subtilis, Staphylococcus aureus, Escherichia coli and a fungal pathogen Candida albicans. Results:The methanolic extracts of leaves collected during rainy season showed maximum zone of inhibition at both the stations Gilakaladindi and Malakayalanka. Among the studied plants leaf methanolic extract of C.tagal was recorded maximum antibacterial activity against B. subtilis and B. cereus (18±0.05 mm), followed by Bruguiera cylindrica both at Gilakaladindi and Malakayalanka respectively. But the extracts of L.racemosa showed less inhibition activity (7±0.00 mm) in all the seasons at both the stations. Conclusion:The study demonstrated that mangroves produce bio-active compounds optimally in rainy season that are effective against microbial proliferation which may further help in synthesis of natural antibiotics in place of commercial antibiotics to heal infectious diseases.

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Antimicrobial activity of polyisoprenoids of sixteen mangrove species from North Sumatra, Indonesia

Cited by 25 publications

References 24 publications

Prominent Secondary Metabolites from Selected Genus of Avicennia Leaves

Prominent Secondary Metabolites from Selected Genus of Avicennia Leaves

Salinity and subsequent freshwater influences on the growth, biomass, and polyisoprenoids distribution of Rhizophora apiculata seedlings

Seasonal and Geographical Variations in Antimicrobial Activity of Selected Mangroves from Krishna Estuary

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