Potential antidiabetic effect of ethanolic and aqueous-ethanolic extracts of<i>Ricinus communis</i>leaves on streptozotocin-induced diabetes in rats

Gad‐Elkareem, Mohamed A. M.; Abdelgadir, Elkhatim H.; Badawy, Ossama M.; Kadri, Adel

doi:10.7717/peerj.6441

Cited by 46 publications

(32 citation statements)

References 28 publications

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“…In the present study, turmeric showed improvement in liver enzymes in the low‐dose group, while the high‐dose and oral curcumin treatment caused an elevation of liver enzymes, especially the ALT serum levels, which is an indication of a dose‐dependent effect of curcumin. Liver enzyme levels are an indicator of the liver cell integrity, and an increase is mostly associated with liver cell damage (Gad‐Elkareem, Abdelgadir, Badawy, & Kadri, , p.; Swamy, Nagalakshmi, Santhosh, & Yogesh, ); therefore, higher doses of turmeric and curcumin as an oral supplement should be avoided in future studies and in clinical trials since they are potentially hepatotoxic.…”

Section: Discussionmentioning

confidence: 99%

Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

et al. 2019

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Herbal remedies have been used for centuries to ameliorate complications of diabetes mellitus (DM). The aim of this study is to compare the effects of the oral curcumin supplement versus parenteral administration of turmeric extract on diabetic complications in a streptozocin (STZ) diabetic model. STZ DM rats received low and high doses turmeric extract intraperitoneally as well as oral curcumin. Curcumin and turmeric extracts significantly reduced blood glucose and creatinine levels, but not urea, and caused an increase in uric acid. Low dose improved liver enzymes, while higher dose and oral administration caused an increase in the ALT and AST. All groups showed an improvement in the serum cholesterol, while the triglycerides were not improved in the high and oral treatment. Histological evaluation showed islet cell protection. High‐dose injection showed almost intact renal corpuscles as well as tubular structures with minimal degeneration. Treatment showed limited protection of Liver tissue. Practical application Curcumin has been heavily marketed as a protective agent. The current study shows some potential risk of curcumin use. Oral and injectable curcumin should be used with caution. Turmeric extract and oral curcumin supplement showed protective effects on pancreatic, and renal structure and function. Although both did show some improvement in liver function, higher doses caused disturbance in liver enzymes and did not show histological evidence of liver tissue protection.

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Section: Discussionmentioning

confidence: 99%

Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

et al. 2019

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“…The non-diabetic rats (negative control) also received normal saline. After 72 h STZ administration, tail blood samples of the overnight fasted rats were collected to measure blood glucose levels [28].…”

Section: Induction Of Diabetesmentioning

confidence: 99%

“…Non-diabetic animals received (60 mg/kg) thymol and thymol nano polymer by gastric gavage needle (NG tube). The untreated normal and diabetic rats were given normal saline [28].…”

Section: Experimental Designmentioning

confidence: 99%

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Anti-Diabetic Effect of a Novel Nano Polymer of Thymol in Streptozotocin-Induced Diabetic Wistar Rats

et al. 2019

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Objective: The aim of this study was to evaluate the effect of thymol and thymol nano polymer on the blood biochemical parameters and anti-diabetic activity in Streptozotocin (STZ)-induced diabetic rats. Methods: The synthesized nano polymer (NP) was characterized by using different spectroscopy methods, such as IR, HNMR and CNMR. Loading and releasing of thymol were investigated by HPLC. Eleven groups of the Streptozotocin-induced diabetic and normal rats (overall 110 males) were tested through various biochemical factors such as: serum glucose, insulin, liver function-related enzymes including ALT, AST, ALP and bilirubin by ELISA kit methods. Results: It has shown that thymol nano polymer is desirable for transferring drug. The amount of thymol loaded on NP estimated at 43±2.5 %. Then, 65% of the loaded drug was released. LD50 for thymol and thymol nano polymer were 435 and 583 mg/kg, respectively. thymol nano polymer at doses of 30, 60 and 90 mg/kg, in a dose-dependent manner, reduced blood glucose, increased insulin levels, and controlled liver enzymes ALT, AST, ALP and bilirubin in the STZ-induced diabetic rats. Conclusion: The use of thymol nano polymer appears to be a new aspect concerning to protect diabetes-induced damage in the animal model.

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“…exBenth, T. polium L., T. popovii R.A. King, and T. yemense Defl [6]. Most plant extracts and their bioactive molecules have been shown to be scavengers of free radicals, which form the basis of their therapeutic potential [7][8][9][10][11]. Their antioxidant nature has been closely linked with the cancer-preventing property of a plant-derived compound due to the fact that the inhibition of oxidative stress reduces mutations and chromosomal aberrations, which initiate carcinogenesis [12].…”

Section: Introductionmentioning

confidence: 99%

HR-LCMS-Based Metabolite Profiling, Antioxidant, and Anticancer Properties of Teucrium polium L. Methanolic Extract: Computational and In Vitro Study

et al. 2020

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In this study, we investigate the phytochemical profile, anticancer, and antioxidant activities of Teucrium polium methanolic extract using both in vitro and in silico approaches. The results showed the identification of 29 phytochemical compounds belonging to 13 classes of compounds and 20 tripeptides using High Resolution-Liquid Chromatography Mass Spectrometry (HR-LCMS). 13R-hydroxy-9E,11Z octadecadienoic acid, dihydrosamidin, valtratum, and cepharantine were the main compounds identified. The tested extract showed promising antioxidant activities (ABTS-IC50 = 0.042 mg/mL; 1,1-diphenyl-2-picrylhydrazyl (DPPH)-IC50 = 0.087 mg/mL, β-carotene-IC50 = 0.101 mg/mL and FRAP-IC50 = 0.292 mg/mL). Using both malignant Walker 256/B and MatLyLu cell lines, T. polium methanolic extract showed a dose/time-dependent antitumor activity. The molecular docking approach revealed that most of the identified molecules were specifically binding with human peroxiredoxin 5, human androgen, and human progesterone receptors with high binding affinity scores. The obtained results confirmed that T. polium is a rich source of bioactive molecules with antioxidant and antitumor potential.

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Potential antidiabetic effect of ethanolic and aqueous-ethanolic extracts ofRicinus communisleaves on streptozotocin-induced diabetes in rats

Cited by 46 publications

References 28 publications

Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

Effects of Turmeric ( Curcuma longa) Extract in streptozocin‐induced diabetic model

Anti-Diabetic Effect of a Novel Nano Polymer of Thymol in Streptozotocin-Induced Diabetic Wistar Rats

HR-LCMS-Based Metabolite Profiling, Antioxidant, and Anticancer Properties of Teucrium polium L. Methanolic Extract: Computational and In Vitro Study

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